Current optimized strategies for stem cell-derived extracellular vesicle/exosomes in cardiac repair

Exosomes mediated fibrogenesis in dilated cardiomyopathy through a MicroRNA pathway

(2023) Xuebin Fu et al.   iScience

GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

(2023) Yu Jin Lee et al.   DEVELOPMENTAL CELL

Intrapericardial long non-coding RNA–Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair

(2023) Dashuai Zhu et al.   EUROPEAN HEART JOURNAL

Differential expression profiles of plasma exosomal microRNAs in dilated cardiomyopathy with chronic heart failure

(2023) Li Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Empagliflozin-Pretreated Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Attenuated Heart Injury

(2023) Boyu Chi et al.   Oxidative Medicine and Cellular Longevity

Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice

(2023) Bin Yu et al.   Nature Communications

Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials

(2023) Ahmed Lotfy et al.   Stem Cell Research & Therapy

Mesenchymal Stem Cell Culture within Perfusion Bioreactors Incorporating 3D‐Printed Scaffolds Enables Improved Extracellular Vesicle Yield with Preserved Bioactivity

(2023) Stephanie M. Kronstadt et al.   Advanced Healthcare Materials

Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways

(2023) Ramana Vaka et al.   Molecular Therapy-Nucleic Acids

Knockdown of deleterious miRNA in progenitor cell–derived small extracellular vesicles enhances tissue repair in myocardial infarction

(2023) Hyun-Ji Park et al.   Science Advances

Injectable photocurable Janus hydrogel delivering hiPSC cardiomyocyte-derived exosome for post–heart surgery adhesion reduction

(2023) Ling Wang et al.   Science Advances

Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy

(2022) Behnoush Sohrabi et al.   CANCER GENE THERAPY

Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization

(2022) Peier Chen et al.   Bioactive Materials

Targeted immunomodulation therapy for cardiac repair by platelet membrane engineering extracellular vesicles via hitching peripheral monocytes

(2022) Qiyu Li et al.   BIOMATERIALS

Biological substrate modification suppresses ventricular arrhythmias in a porcine model of chronic ischaemic cardiomyopathy

(2022) James F. Dawkins et al.   EUROPEAN HEART JOURNAL

Serum exosomal long non-coding RNAs as a diagnostic biomarker for atrial fibrillation

(2022) Ji-Young Kang et al.   HEART RHYTHM

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

(2022) Christine M. Poch et al.   NATURE CELL BIOLOGY

Nonhuman Primates in Translational Research

(2022) Alice F. Tarantal et al.   Annual Review of Animal Biosciences

Islet-1 Mesenchymal Stem Cells-Derived Exosome-Incorporated Angiogenin-1 Hydrogel for Enhanced Acute Myocardial Infarction Therapy

(2022) Xinyi Hu et al.   ACS Applied Materials & Interfaces

Minimally invasive delivery of a hydrogel-based exosome patch to prevent heart failure

(2022) George Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway

(2022) Yuyan Xiong et al.   Stem Cell Research & Therapy

IFN-γ enhances the efficacy of mesenchymal stromal cell-derived exosomes via miR-21 in myocardial infarction rats

(2022) Jian Zhang et al.   Stem Cell Research & Therapy

Protective Effects of MicroRNA‐200b‐3p Encapsulated by Mesenchymal Stem Cells–Secreted Extracellular Vesicles in Myocardial Infarction Via Regulating BCL2L11

(2022) Jun Wan et al.   Journal of the American Heart Association

Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells

(2022) Xuegang Yuan et al.   Journal of Extracellular Vesicles

Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile

(2022) Richard Jeske et al.   Bioactive Materials

Biomaterial-embedded extracellular vesicles improve recovery of the dysfunctional myocardium

(2022) Chloé Pezzana et al.   BIOMATERIALS

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

(2022) Dashuai Zhu et al.   CIRCULATION RESEARCH

Exosomal thioredoxin-1 from hypoxic human umbilical cord mesenchymal stem cells inhibits ferroptosis in doxorubicin-induced cardiotoxicity via mTORC1 signaling

(2022) Yue Yu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Engineering stem cell therapeutics for cardiac repair

(2022) Jun Fang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

(2022) Qing-Fang Han et al.   Molecular Cancer

Heart-targeting exosomes from human cardiosphere-derived cells improve the therapeutic effect on cardiac hypertrophy

(2022) Liang Mao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Impact of storage conditions and duration on function of native and cargo-loaded mesenchymal stromal cell extracellular vesicles

(2022) Daniel Levy et al.   CYTOTHERAPY

Extracellular vesicles DJ-1 derived from hypoxia-conditioned hMSCs alleviate cardiac hypertrophy by suppressing mitochondria dysfunction and preventing ATRAP degradation

(2022) Yao Lu et al.   PHARMACOLOGICAL RESEARCH

Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions

(2021) Jun-Yong Wu et al.   DRUG DELIVERY

Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell–Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium

(2021) Gentaro Ikeda et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates

(2021) Qingju Li et al.   Science Translational Medicine

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

(2021) Dashuai Zhu et al.   Nature Communications

Conductive biomaterials for cardiac repair: A review☆

(2021) Yimeng Li et al.   Acta Biomaterialia

miR-106a–363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury

(2021) Ji-Hye Jung et al.   BASIC RESEARCH IN CARDIOLOGY

Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction

(2021) Meng Zhao et al.   CIRCULATION

Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo

(2021) Sezin Aday et al.   MOLECULAR THERAPY

Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production

(2021) Demin Liu et al.   Redox Biology

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

(2021) Jialu Yao et al.   ACS Nano

Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment

(2021) Zilun Wei et al.   BIOMATERIALS

Immune Cells and Immunotherapy for Cardiac Injury and Repair

(2021) Joel G. Rurik et al.   CIRCULATION RESEARCH

Mesenchymal stromal cell-derived exosomes in cardiac regeneration and repair

(2021) Si-Jia Sun et al.   Stem Cell Reports

Restoring Cardiac Functions after Myocardial Infarction–Ischemia/Reperfusion via an Exosome Anchoring Conductive Hydrogel

(2021) Yang Zou et al.   ACS Applied Materials & Interfaces

Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart

(2021) Mallikarjun Patil et al.   CIRCULATION RESEARCH

Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies

(2021) Sabine Steffens et al.   EUROPEAN HEART JOURNAL

Influence of short term storage conditions, concentration methods and excipients on extracellular vesicle recovery and function

(2021) S.I. van de Wakker et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Exosomes from adipose-derived stem cells alleviate myocardial infarction via microRNA-31/FIH1/HIF-1α pathway

(2021) Dihan Zhu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Basic and Translational Research in Cardiac Repair and Regeneration

(2021) Jianyi Zhang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis

(2021) Hongjuan Ning et al.   Stem Cell Research & Therapy

Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

(2021) Huifeng Zheng et al.   JOURNAL OF NANOBIOTECHNOLOGY

Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction

(2021) Marta Monguió-Tortajada et al.   Bioactive Materials

Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts

(2020) Bruna Lima Correa et al.   CARDIOVASCULAR RESEARCH

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

(2020) Ricardo Cerqueira de Abreu et al.   Nature Reviews Cardiology

Exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2

(2020) Yi Peng et al.   Cell Death & Disease

Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis

(2020) Qiang Wu et al.   Cell Death & Disease

Nanovesicles derived from iron oxide nanoparticles–incorporated mesenchymal stem cells for cardiac repair

(2020) Ju-Ro Lee et al.   Science Advances

Myofibroblasts and Fibrosis

(2020) Andrew A. Gibb et al.   CIRCULATION RESEARCH

Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice

(2020) Yuto Nakamura et al.   MOLECULAR THERAPY

Monocyte mimics improve mesenchymal stem cell-derived extracellular vesicle homing in a mouse MI/RI model

(2020) Ning Zhang et al.   BIOMATERIALS

Angiogenesis After Acute Myocardial Infarction

(2020) Xuekun Wu et al.   CARDIOVASCULAR RESEARCH

RAB31 marks and controls an ESCRT-independent exosome pathway

(2020) Denghui Wei et al.   CELL RESEARCH

Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine

(2020) Ling Gao et al.   Science Translational Medicine

Long noncoding RNA UCA1 from hypoxia-conditioned hMSC-derived exosomes: a novel molecular target for cardioprotection through miR-873-5p/XIAP axis

(2020) Ling Sun et al.   Cell Death & Disease

HIF-1α overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis

(2020) Jiacheng Sun et al.   Stem Cell Research & Therapy

Exosomes from SIRT1-Overexpressing ADSCs Restore Cardiac Function by Improving Angiogenic Function of EPCs

(2020) Hui Huang et al.   Molecular Therapy-Nucleic Acids

Trophoblast stem cell-derived exosomes improve doxorubicin-induced dilated cardiomyopathy by modulating the let-7i/YAP pathway

(2020) Jie Ni et al.   Molecular Therapy-Nucleic Acids

Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy

(2020) Kenta Hirai et al.   Science Translational Medicine

Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells

(2020) Zheng-gang Wang et al.   Stem Cell Research & Therapy

Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure

(2019) Songyan Liao et al.   Stem Cell Research & Therapy

Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

(2019) Alessandra Ciullo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

(2019) Jinxuan Zhao et al.   CARDIOVASCULAR RESEARCH

Atorvastatin Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells Derived Exosomes in Acute Myocardial Infarction via Up-regulating Long Non-coding RNA H19

(2019) Peisen Huang et al.   CARDIOVASCULAR RESEARCH

Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-κB/TNF-α Signaling Pathway

(2019) Bao Zhu et al.   Oxidative Medicine and Cellular Longevity

Interleukin-10 Deficiency Alters Endothelial Progenitor Cell–Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment

(2019) Yujia Yue et al.   CIRCULATION RESEARCH

LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis

(2019) Qing Mao et al.   Stem Cell Research & Therapy

Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue ContractilityNovelty and Significance

(2018) Joshua Mayourian et al.   CIRCULATION RESEARCH

Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman PrimatesNovelty and Significance

(2018) Keyang Zhu et al.   CIRCULATION RESEARCH

Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b

(2018) Changchen Xiao et al.   CIRCULATION RESEARCH

Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates

(2018) Yen-Wen Liu et al.   NATURE BIOTECHNOLOGY

Concise Review: Optimized Strategies for Stem Cell-Based Therapy in Myocardial Repair: Clinical Translatability and Potential Limitation

(2018) Rongrong Wu et al.   STEM CELLS

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

(2018) Adam Vandergriff et al.   Theranostics

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

(2018) Bohao Liu et al.   Nature Biomedical Engineering

Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system

(2018) Divya B. Patel et al.   Acta Biomaterialia

Cell surface engineering and application in cell delivery to heart diseases

(2018) Daniel Y. Lee et al.   Journal of Biological Engineering

2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation

(2017) Borja Ibanez et al.   EUROPEAN HEART JOURNAL

Induced Pluripotent Stem Cell (iPSC)–Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs

(2017) Marta Adamiak et al.   CIRCULATION RESEARCH

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

(2016) Hongzhao Qi et al.   ACS Nano

A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman PrimatesNovelty and Significance

(2016) Xinyang Hu et al.   CIRCULATION RESEARCH

Cardiovascular progenitor–derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure

(2016) Anaïs Kervadec et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts

(2016) Yuji Shiba et al.   NATURE

Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model

(2016) Guadalupe Gómez-Mauricio et al.   Stem Cell Research & Therapy

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

(2015) M. Khan et al.   CIRCULATION RESEARCH

Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial

(2015) Xinyang Hu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cell Therapy Needs Rigorous Translational Studies in Large Animal Models ∗

(2015) Roberto Bolli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Percutaneous Intramyocardial Delivery of Mesenchymal Stem Cells Induces Superior Improvement in Regional Left Ventricular Function Compared with Bone Marrow Mononuclear Cells in Porcine Myocardial Infarcted Heart

(2015) Bo Tao et al.   Theranostics

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

(2014) James J. H. Chong et al.   NATURE

A detailed comparison of mouse and human cardiac development

(2014) Anita Krishnan et al.   PEDIATRIC RESEARCH

Magnetic Targeting Enhances Engraftment and Functional Benefit of Iron-Labeled Cardiosphere-Derived Cells in Myocardial Infarction

(2010) Ke Cheng et al.   CIRCULATION RESEARCH