Engineering stem cell therapeutics for cardiac repair

Mending broken hearts with the help of epigenetic remodellers

(2021) Kim Baumann   Nature Reviews Cardiology

Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro

(2021) Jun Fang et al.   Nature Biomedical Engineering

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

(2021) Jialu Yao et al.   ACS Nano

Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes

(2021) Kenta Nakamura et al.   Stem Cell Reports

A framework for developing sex-specific engineered heart models

(2021) Roberta Lock et al.   Nature Reviews Materials

Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming

(2020) Jun Fang et al.   ACS Nano

Toward the Goal of Human Heart Regeneration

(2020) Hesham Sadek et al.   Cell Stem Cell

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

(2020) Elaheh Karbassi et al.   Nature Reviews Cardiology

Stem cells and the heart—the road ahead

(2020) Charles E. Murry et al.   SCIENCE

Tailorable Hydrogel Improves Retention and Cardioprotection of Intramyocardial Transplanted Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice

(2020) Youhu Chen et al.   Journal of the American Heart Association

A Cell-Free SDKP-Conjugated Self-Assembling Peptide Hydrogel Sufficient for Improvement of Myocardial Infarction

(2020) Saman Firoozi et al.   Biomolecules

Cell Engineering with Functional Poly(oxanorbornene) Block Copolymers

(2020) Derek C. Church et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Next-generation stem cells — ushering in a new era of cell-based therapies

(2020) Erin A. Kimbrel et al.   NATURE REVIEWS DRUG DISCOVERY

Heart regeneration using pluripotent stem cells

(2020) Shin Kadota et al.   Journal of Cardiology

Instant tough bioadhesive with triggerable benign detachment

(2020) Xiaoyu Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locoregional delivery of stem cell–based therapies

(2020) Nathan Norton Ng et al.   Science Translational Medicine

4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction

(2020) Haitao Cui et al.   Science Advances

Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease

(2020) Hongpeng Shi et al.   Science Advances

Strategies for Genetically Engineering Hypoimmunogenic Universal Pluripotent Stem Cells

(2020) Wei Zhao et al.   iScience

Tissue engineering using a combined cell sheet technology and scaffolding approach

(2020) Irina M. Zurina et al.   Acta Biomaterialia

Injectable Drug‐Releasing Microporous Annealed Particle Scaffolds for Treating Myocardial Infarction

(2020) Jun Fang et al.   ADVANCED FUNCTIONAL MATERIALS

FRESH 3D Bioprinting a Full-Size Model of the Human Heart

(2020) Eman Mirdamadi et al.   ACS Biomaterials-Science & Engineering

Thermally-triggered fabrication of cell sheets for tissue engineering and regenerative medicine

(2019) Hironobu Takahashi et al.   ADVANCED DRUG DELIVERY REVIEWS

Regenerating the field of cardiovascular cell therapy

(2019) Kenneth R. Chien et al.   NATURE BIOTECHNOLOGY

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

(2019) Huaigeng Xu et al.   Cell Stem Cell

Manufacturing of primed mesenchymal stromal cells for therapy

(2019) James Q. Yin et al.   Nature Biomedical Engineering

Stem Cells in the Treatment of Disease

(2019) Helen M. Blau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction

(2019) Andrea S. Carlini et al.   Nature Communications

Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarction

(2019) Yasumoto Matsumura et al.   BIOMATERIALS

Clinical Translation of Pluripotent Stem Cell Therapies: Challenges and Considerations

(2019) Manon Desgres et al.   Cell Stem Cell

Dry double-sided tape for adhesion of wet tissues and devices

(2019) Hyunwoo Yuk et al.   NATURE

Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair

(2019) Jeffrey J. D. Henry et al.   Advanced Healthcare Materials

Synergistic effects of adipose-derived stem cells combined with decellularized myocardial matrix on the treatment of myocardial infarction in rats

(2019) Liang Qiao et al.   LIFE SCIENCES

Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

(2018) Tamer M.A. Mohamed et al.   CELL

Genetic Lineage Tracing of Non-Myocyte Population by Dual Recombinases

(2018) Yan Li et al.   CIRCULATION

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates

(2018) Yen-Wen Liu et al.   NATURE BIOTECHNOLOGY

Regeneration: Mending broken hearts

(2018) Paulina Strzyz   Nature Reviews Cardiology

Therapeutic approaches for cardiac regeneration and repair

(2018) Hisayuki Hashimoto et al.   Nature Reviews Cardiology

Cell therapy trials for heart regeneration — lessons learned and future directions

(2018) Philippe Menasché   Nature Reviews Cardiology

Contractile force measurement of human induced pluripotent stem cell-derived cardiac cell sheet-tissue

(2018) Daisuke Sasaki et al.   PLoS One

Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

(2018) Harsha D. Devalla et al.   Science Translational Medicine

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

(2018) Junnan Tang et al.   Nature Biomedical Engineering

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

(2018) Bohao Liu et al.   Nature Biomedical Engineering

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair

(2018) Zhenhua Li et al.   ACS Nano

Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell–Derived Cells: Universal Donor for Cell Therapy

(2018) Saidulu Mattapally et al.   Journal of the American Heart Association

Cardiac cell–integrated microneedle patch for treating myocardial infarction

(2018) Junnan Tang et al.   Science Advances

Stem cell therapies for myocardial infarction in clinical trials: bioengineering and biomaterial aspects

(2017) Akon Higuchi et al.   LABORATORY INVESTIGATION

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics

(2017) Thomas J. Cahill et al.   NATURE REVIEWS DRUG DISCOVERY

Acute Myocardial Infarction

(2017) Jeffrey L. Anderson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

(2017) Ilya Y. Shadrin et al.   Nature Communications

Treatment of Myocardial Infarction with Gene-modified Mesenchymal Stem Cells in a Small Molecular Hydrogel

(2017) Zhiye Wu et al.   Scientific Reports

Targeted Genome Engineering to Control VEGF Expression in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells: Potential Implications for the Treatment of Myocardial Infarction

(2017) Hyun-Min Cho et al.   Stem Cells Translational Medicine

CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2017) Wuqiang Zhu et al.   CIRCULATION RESEARCH

Cardiac spheroids as promising in vitro models to study the human heart microenvironment

(2017) Liudmila Polonchuk et al.   Scientific Reports

Decellularized myocardial matrix hydrogels: In basic research and preclinical studies

(2016) Raymond M. Wang et al.   ADVANCED DRUG DELIVERY REVIEWS

Self-assembling peptide-based delivery of therapeutics for myocardial infarction

(2016) Kristin M. French et al.   ADVANCED DRUG DELIVERY REVIEWS

Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair

(2016) Matthew E. Hartman et al.   ADVANCED DRUG DELIVERY REVIEWS

Three-dimensional cardiac tissue fabrication based on cell sheet technology

(2016) Shinako Masuda et al.   ADVANCED DRUG DELIVERY REVIEWS

Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model

(2016) Antonio D'Amore et al.   BIOMATERIALS

Enhancement of cell adhesion, retention, and survival of HUVEC/cbMSC aggregates that are transplanted in ischemic tissues by concurrent delivery of an antioxidant for therapeutic angiogenesis

(2016) Chieh-Cheng Huang et al.   BIOMATERIALS

Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts

(2016) Yuji Shiba et al.   NATURE

Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery

(2016) Angelo S. Mao et al.   NATURE MATERIALS

Induced pluripotent stem cells: at the heart of cardiovascular precision medicine

(2016) Ian Y. Chen et al.   Nature Reviews Cardiology

Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells

(2016) F. Weinberger et al.   Science Translational Medicine

Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction

(2016) Shuting Zhao et al.   Nature Communications

Highly Angiogenic Peptide Nanofibers

(2015) Vivek A. Kumar et al.   ACS Nano

Multimodality noninvasive imaging for assessing therapeutic effects of exogenously transplanted cell aggregates capable of angiogenesis on acute myocardial infarction

(2015) Chieh-Cheng Huang et al.   BIOMATERIALS

Immuno-modification of enhancing stem cells targeting for myocardial repair

(2015) Jiashing Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Gene therapy to treat cardiac arrhythmias

(2015) Rossana Bongianino et al.   Nature Reviews Cardiology

Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells

(2015) Takehiko Matsuo et al.   Scientific Reports

Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

(2015) Anwarul Hasan et al.   Advanced Science

The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes

(2014) Anton Mihic et al.   BIOMATERIALS

Patching Up Broken Hearts: Cardiac Cell Therapy Gets a Bioengineered Boost

(2014) Vahid Serpooshan et al.   Cell Stem Cell

Cardiac Repair in a Porcine Model of Acute Myocardial Infarction with Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells

(2014) Lei Ye et al.   Cell Stem Cell

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

(2014) James J. H. Chong et al.   NATURE

Chemically defined generation of human cardiomyocytes

(2014) Paul W Burridge et al.   NATURE METHODS

Human Stem Cells for Modeling Heart Disease and for Drug Discovery

(2014) E. Matsa et al.   Science Translational Medicine

Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting

(2014) Ke Cheng et al.   Nature Communications

Potential and Limitation of HLA-Based Banking of Human Pluripotent Stem Cells for Cell Therapy

(2014) Casimir de Rham et al.   Journal of Immunology Research

The use of aggregates of purified cardiomyocytes derived from human ESCs for functional engraftment after myocardial infarction

(2013) Sung-Hwan Moon et al.   BIOMATERIALS

The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction

(2013) Vahid Serpooshan et al.   BIOMATERIALS

The effect of a peptide-modified thermo-reversible methylcellulose on wound healing and LV function in a chronic myocardial infarction rodent model

(2013) Shirley S. Mihardja et al.   BIOMATERIALS

Intramuscular delivery of 3D aggregates of HUVECs and cbMSCs for cellular cardiomyoplasty in rats with myocardial infarction

(2013) Ding-Yuan Chen et al.   JOURNAL OF CONTROLLED RELEASE

Cell sheet transplantation for heart tissue repair

(2013) Katsuhisa Matsuura et al.   JOURNAL OF CONTROLLED RELEASE

Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells

(2013) Armin Arshi et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Safety and Efficacy of an Injectable Extracellular Matrix Hydrogel for Treating Myocardial Infarction

(2013) S. B. Seif-Naraghi et al.   Science Translational Medicine

In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels

(2013) Hidekazu Sekine et al.   Nature Communications

In Vitro Engineering of Vascularized Tissue Surrogates

(2013) Katsuhisa Sakaguchi et al.   Scientific Reports

Small Molecule-Mediated Directed Differentiation of Human Embryonic Stem Cells Toward Ventricular Cardiomyocytes

(2013) Ioannis Karakikes et al.   Stem Cells Translational Medicine

The influence of chitosan hydrogel on stem cell engraftment, survival and homing in the ischemic myocardial microenvironment

(2012) Zhiqiang Liu et al.   BIOMATERIALS

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Shugo Tohyama et al.   Cell Stem Cell

Bioenergetic and Functional Consequences of Cellular Therapy

(2012) Qiang Xiong et al.   CIRCULATION RESEARCH

Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro

(2012) George Kensah et al.   EUROPEAN HEART JOURNAL

Towards regenerative therapy for cardiac disease

(2012) Leon M Ptaszek et al.   LANCET

Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

(2012) Yuji Shiba et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Adult Cardiac Progenitor Cell Aggregates Exhibit Survival Benefit Both In Vitro and In Vivo

(2012) Michael Bauer et al.   PLoS One

Functional Supramolecular Polymers

(2012) T. Aida et al.   SCIENCE

Designing Regenerative Biomaterial Therapies for the Clinic

(2012) E. T. Pashuck et al.   Science Translational Medicine

Vascularization is the key challenge in tissue engineering

(2011) Esther C. Novosel et al.   ADVANCED DRUG DELIVERY REVIEWS

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents

(2011) Junyi Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells

(2011) Suk Ho Bhang et al.   BIOMATERIALS

Induced Adipocyte Cell-Sheet Ameliorates Cardiac Dysfunction in a Mouse Myocardial Infarction Model: A Novel Drug Delivery System for Heart Failure

(2011) Y. Imanishi et al.   CIRCULATION

Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges

(2011) Jörn Tongers et al.   EUROPEAN HEART JOURNAL

Nitric Oxide Synthase Gene Transfer Restores Activity of Circulating Angiogenic Cells From Patients With Coronary Artery Disease

(2011) Michael R Ward et al.   MOLECULAR THERAPY

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells

(2011) Nicole C Dubois et al.   NATURE BIOTECHNOLOGY

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

The Role of Chemokines in Mesenchymal Stem Cell Homing to Myocardium

(2011) Yaojiong Wu et al.   Stem Cell Reviews and Reports

The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat

(2010) Jiashing Yu et al.   BIOMATERIALS

Intramyocardial Peptide Nanofiber Injection Improves Postinfarction Ventricular Remodeling and Efficacy of Bone Marrow Cell Therapy in Pigs

(2010) Y.-D. Lin et al.   CIRCULATION

Bone marrow stem cells implantation with α-cyclodextrin/MPEG–PCL–MPEG hydrogel improves cardiac function after myocardial infarction

(2009) Tao Wang et al.   Acta Biomaterialia

Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology

(2009) Tadashi Sasagawa et al.   BIOMATERIALS

Mesenchymal Stem Cell Homing: The Devil Is in the Details

(2009) Jeffrey M. Karp et al.   Cell Stem Cell

Cardiac Progenitor Cells and Biotinylated Insulin-Like Growth Factor-1 Nanofibers Improve Endogenous and Exogenous Myocardial Regeneration After Infarction

(2009) M. Elena Padin-Iruegas et al.   CIRCULATION

Hypoxic Preconditioning Enhances the Benefit of Cardiac Progenitor Cell Therapy for Treatment of Myocardial Infarction by Inducing CXCR4 Expression

(2009) Yao Liang Tang et al.   CIRCULATION RESEARCH

Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair

(2008) Hao-Ji Wei et al.   BIOMATERIALS

Systems approaches to preventing transplanted cell death in cardiac repair

(2008) Thomas E. Robey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Stem-cell-based therapy and lessons from the heart

(2008) Robert Passier et al.   NATURE

Genetic modification of stem cells for transplantation

(2007) M. Ian Phillips et al.   ADVANCED DRUG DELIVERY REVIEWS