Exosomal thioredoxin-1 from hypoxic human umbilical cord mesenchymal stem cells inhibits ferroptosis in doxorubicin-induced cardiotoxicity via mTORC1 signaling

Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p

(2021) Wenwu Zhu et al.   JOURNAL OF NANOBIOTECHNOLOGY

ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity

(2021) Xiaoting Wu et al.   MOLECULAR THERAPY

Exosomal Micro‐RNA‐96 Derived From Bone Marrow Mesenchymal Stem Cells Inhibits Doxorubicin‐Induced Myocardial Toxicity by Inhibiting the Rac1/Nuclear Factor‐κB Signaling Pathway

(2021) Bo Lei et al.   Journal of the American Heart Association

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

(2021) Kai Hou et al.   EBioMedicine

Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

(2021) Huifeng Zheng et al.   JOURNAL OF NANOBIOTECHNOLOGY

A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity

(2021) Mengjie Xiao et al.   Redox Biology

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a

(2020) Dong Han et al.   CIRCULATION RESEARCH

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

(2020) Xiaoguang Liu et al.   NATURE CELL BIOLOGY

NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy

(2020) Cheng Zeng et al.   Redox Biology

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2020) Tomonori Tadokoro et al.   JCI Insight

Long noncoding RNA UCA1 from hypoxia-conditioned hMSC-derived exosomes: a novel molecular target for cardioprotection through miR-873-5p/XIAP axis

(2020) Ling Sun et al.   Cell Death & Disease

Trophoblast stem cell-derived exosomes improve doxorubicin-induced dilated cardiomyopathy by modulating the let-7i/YAP pathway

(2020) Jie Ni et al.   Molecular Therapy-Nucleic Acids

Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Protect Liver Ischemia/Reperfusion Injury by Reducing CD154 Expression on CD4+ T Cells via CCT2

(2020) Jun Zheng et al.   Advanced Science

Natural Molecules Targeting Thioredoxin System and Their Therapeutic Potential

(2020) Junmin Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

(2020) Junmei Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human trophoblast-derived exosomes attenuate doxorubicin-induced cardiac injury by regulating miR-200b and downstream Zeb1

(2020) Jie Ni et al.   JOURNAL OF NANOBIOTECHNOLOGY

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart

(2019) Shin-Ichi Oka et al.   CARDIOVASCULAR RESEARCH

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

(2019) Giovanni Miotto et al.   Redox Biology

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes

(2017) Shin-ichi Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction

(2014) Siying Li et al.   Oxidative Medicine and Cellular Longevity

Selenium and selenocysteine: roles in cancer, health, and development

(2014) Dolph L. Hatfield et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin

(2012) Marina Bayeva et al.   Cell Metabolism

Doxorubicin: The Good, the Bad and the Ugly Effect

(2009) Cristina Carvalho et al.   CURRENT MEDICINAL CHEMISTRY