Finding the best location: Improving the anti-amyloid ability of ruthenium(III) complexes with pyridine ligands

Anti-amyloid antibody therapies in Alzheimer's disease

(2023) Robert Perneczky et al.   BRAIN

The affordability of lecanemab, an amyloid-targeting therapy for Alzheimer's disease: an EADC-EC viewpoint

(2023) Linus Jönsson et al.   The Lancet Regional Health Europe

A Dual-Pronged Approach: A Ruthenium(III) Complex That Modulates Amyloid-β Aggregation and Disrupts Its Formed Aggregates

(2022) Gideon K. Yawson et al.   INORGANIC CHEMISTRY

Lecanemab in Early Alzheimer’s Disease

(2022) Christopher H. van Dyck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early diagnosis and treatment of Alzheimer’s disease by targeting toxic soluble Aβ oligomers

(2022) Maram Habashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of Hydrogen Bonding: Structure–Activity Relationships of Ruthenium(III) Complexes with Pyridine-Based Ligands for Alzheimer’s Disease Therapy

(2021) Brendan J. Wall et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Amyloid-β Pathway in Alzheimer’s Disease

(2021) Harald Hampel et al.   MOLECULAR PSYCHIATRY

A Paramagnetic NMR Spectroscopy Toolbox for the Characterisation of Paramagnetic/Spin‐Crossover Coordination Complexes and Metal‐Organic Cages

(2020) Marc Lehr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifunctional Compounds for the Treatment of Alzheimer’s Disease

(2020) Tim Storr   Canadian Journal of Chemistry

Ruthenium(III) complexes with imidazole ligands that modulate the aggregation of the amyloid-β peptide via hydrophobic interactions

(2020) Gideon K. Yawson et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry

(2019) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Modification of Aβ Peptide Aggregation via Covalent Binding of a Series of Ru(III) Complexes

(2019) Luiza M. F. Gomes et al.   Frontiers in Chemistry

Light-triggered dissociation of self-assembled β-amyloid aggregates into small, nontoxic fragments by ruthenium (II) complex

(2018) Giyeong Son et al.   Acta Biomaterialia

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Interpreting the Paramagnetic NMR Spectra of Potential Ru(III) Metallodrugs: Synergy between Experiment and Relativistic DFT Calculations

(2016) Jan Novotný et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulation of the Aβ peptide aggregation pathway by KP1019 limits Aβ-associated neurotoxicity

(2015) Michael R. Jones et al.   Metallomics

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Tuning the cytotoxic properties of new ruthenium(III) and ruthenium(II) complexes with a modified bis(arylimino)pyridine Schiff base ligand using bidentate pyridine-based ligands

(2014) Ariadna Garza-Ortiz et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Simultaneous Measurement of Amyloid Fibril Formation by Dynamic Light Scattering and Fluorescence Reveals Complex Aggregation Kinetics

(2013) Aaron M. Streets et al.   PLoS One

Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex

(2013) Luigi Messori et al.   ACS Medicinal Chemistry Letters

Facile Methodology for Monitoring Amyloid-β Fibrillization

(2012) Nathan P. Cook et al.   ACS Chemical Neuroscience

The Toxicity of Amyloid ß Oligomers

(2012) Li Na Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of [PtCl2(phen)] Binding Modes in Amyloid-β Peptide and the Mechanism of Aggregation Inhibition

(2011) Guolin Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Control of ligand-exchange processes and the oxidation state of the antimetastatic Ru(iii) complex NAMI-A by interactions with human serum albumin

(2011) Michael I. Webb et al.   DALTON TRANSACTIONS

Pyridine Analogues of the Antimetastatic Ru(III) Complex NAMI-A Targeting Non-Covalent Interactions with Albumin

(2011) Michael I. Webb et al.   INORGANIC CHEMISTRY

The Upside of APP at Synapses

(2010) Hyang-Sook Hoe et al.   CNS Neuroscience & Therapeutics

fac-{Ru(CO)3}2+Selectively Targets the Histidine Residues of the β-Amyloid Peptide 1-28. Implications for New Alzheimer's Disease Treatments Based on Ruthenium Complexes

(2010) Daniela Valensin et al.   INORGANIC CHEMISTRY

Neuropathology of Alzheimer's Disease

(2010) Daniel P. Perl   MOUNT SINAI JOURNAL OF MEDICINE

A categorization of metal anticancer compounds based on their mode of action

(2009) Teresa Gianferrara et al.   DALTON TRANSACTIONS

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

Platinum-based inhibitors of amyloid-  as therapeutic agents for Alzheimer's disease

(2008) K. J. Barnham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA