Multifunctional Compounds for the Treatment of Alzheimer’s Disease

NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry

(2019) Enzo Alessio et al.   MOLECULES

Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit

(2019) Elizabeth W. Hunsaker et al.   INORGANIC CHEMISTRY

Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy

(2019) Bo Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A small bifunctional chelator that modulates Aβ42 aggregation

(2018) Chaofeng Zhang et al.   CANADIAN JOURNAL OF CHEMISTRY

Amyloid β-targeted metal complexes for potential applications in Alzheimer's disease

(2018) Hao Liu et al.   Future Medicinal Chemistry

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

(2018) Masha G. Savelieff et al.   CHEMICAL REVIEWS

Multifunctional Compounds for Activation of the p53 Y220C Mutant in Cancer

(2018) Jessica J Miller et al.   CHEMISTRY-A EUROPEAN JOURNAL

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Strategies Employing Transition Metal Complexes To Modulate Amyloid-β Aggregation

(2018) Jong-Min Suh et al.   INORGANIC CHEMISTRY

Chelating principles in Menkes and Wilson diseases

(2018) Nina Horn et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A systematic review and evidence-based guideline for diagnosis and treatment of Menkes disease

(2018) Filippo Pinto e Vairo et al.   MOLECULAR GENETICS AND METABOLISM

CuII Binding to Various Forms of Amyloid-β Peptides: Are They Friends or Foes?

(2017) Valentina Borghesani et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides

(2017) Jeffrey S. Derrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A clinicopathological approach to the diagnosis of dementia

(2017) Fanny M. Elahi et al.   Nature Reviews Neurology

Photochemical Identification of Molecular Binding Sites on the Surface of Amyloid-β Fibrillar Aggregates

(2017) Amir Aliyan et al.   Chem

Stimulus-Responsive Prochelators for Manipulating Cellular Metals

(2016) Qin Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-β peptide aggregation

(2016) Michael R. Jones et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Haemochromatosis

(2016) Lawrie W Powell et al.   LANCET

Free Superoxide is an Intermediate in the Production of H2 O2 by Copper(I)-Aβ Peptide and O2

(2015) Karine Reybier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease

(2014) David J. Hayne et al.   CHEMICAL SOCIETY REVIEWS

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation

(2014) Luiza M.F. Gomes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Pt(ii) compounds interplay with Cu(ii) and Zn(ii) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

(2013) Fabrice Collin et al.   CHEMICAL COMMUNICATIONS

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

(2013) Wendy Noble et al.   Frontiers in Neurology

Werner coordination chemistry and neurodegeneration

(2012) Maria A. Telpoukhovskaia et al.   CHEMICAL SOCIETY REVIEWS

Metal binding sites in amyloid oligomers: Complexes and mechanisms

(2012) Yifat Miller et al.   COORDINATION CHEMISTRY REVIEWS

Multifunctional Ligands in Medicinal Inorganic Chemistry- Current Trends and Future Directions

(2012) Linus Chiang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual-function triazole–pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation

(2012) Michael R. Jones et al.   Metallomics

Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

(2012) Desiree Antequera et al.   NEUROBIOLOGY OF DISEASE

The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

(2011) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

(2010) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation

(2010) Drew S. Folk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

(2010) James A. Duce et al.   PROGRESS IN NEUROBIOLOGY

Protecting the beneficial functionality of lipoproteins by 1-Fe, a corrole-based catalytic antioxidant

(2010) Adi Haber et al.   Chemical Science

Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease

(2009) Lauren E. Scott et al.   CHEMICAL REVIEWS

Metalloproteins and metal sensing

(2009) Kevin J. Waldron et al.   NATURE

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Platinum-based inhibitors of amyloid-  as therapeutic agents for Alzheimer's disease

(2008) K. J. Barnham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA