A Dual-Pronged Approach: A Ruthenium(III) Complex That Modulates Amyloid-β Aggregation and Disrupts Its Formed Aggregates

Utilization of Guanidine-Based Ancillary Ligands in Arene–Ruthenium Complexes for Selective Cytotoxicity

(2021) Jit Karmakar et al.   ACS Omega

Importance of Hydrogen Bonding: Structure–Activity Relationships of Ruthenium(III) Complexes with Pyridine-Based Ligands for Alzheimer’s Disease Therapy

(2021) Brendan J. Wall et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal complexes that bind to the amyloid-β peptide of relevance to Alzheimer’s disease

(2020) Luiza M.F. Gomes et al.   COORDINATION CHEMISTRY REVIEWS

Ruthenium (II) Catalyzed C(sp 2 )−H Bond Alkenylation of 2‐Arylbenzo[ d ]oxazole and 2‐Arylbenzo[ d ]thiazole with Unactivated Olefins

(2020) Bhavin V. Pipaliya et al.   Chemistry-An Asian Journal

Ruthenium(III) complexes with imidazole ligands that modulate the aggregation of the amyloid-β peptide via hydrophobic interactions

(2020) Gideon K. Yawson et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Histidine Targeting Heterobimetallic Ruthenium(II)–Gold(I) Complexes

(2019) Lucinda K. Batchelor et al.   INORGANIC CHEMISTRY

Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki-Miyaura Reactions of Bromooxazole Building Blocks

(2019) Vitalii V. Solomin et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Ruthenium – A Non-essential Element that May Become Essential in Treating Chemoresistant Cancers

(2019) Paul J. Dyson   CHIMIA

NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry

(2019) Enzo Alessio et al.   MOLECULES

Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer’s Disease and Related Dementias and Strategic Implications for Stakeholders

(2019) Youssef H. El-Hayek et al.   JOURNAL OF ALZHEIMERS DISEASE

Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry

(2019) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Modification of Aβ Peptide Aggregation via Covalent Binding of a Series of Ru(III) Complexes

(2019) Luiza M. F. Gomes et al.   Frontiers in Chemistry

(Pyridyl)benzoazole ruthenium(III) complexes: Kinetics of ligand substitution reaction and potential cytotoxic properties

(2018) Reinner Ochola Omondi et al.   INORGANICA CHIMICA ACTA

Strategies Employing Transition Metal Complexes To Modulate Amyloid-β Aggregation

(2018) Jong-Min Suh et al.   INORGANIC CHEMISTRY

Photochemical Properties and Structure-Activity Relationships of RuIIComplexes with Pyridylbenzazole Ligands as Promising Anticancer Agents

(2017) Dmytro Havrylyuk et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Organoruthenium(II) compounds with pyridyl benzoxazole/benzthiazole moiety: studies on DNA/protein binding and enzyme mimetic activities

(2017) Asaithambi Gomathi et al.   JOURNAL OF COORDINATION CHEMISTRY

Characterizing activation mechanisms and binding preferences of ruthenium metallo-prodrugs by a competitive binding assay

(2017) Christian Artner et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

GRP78 at the Centre of the Stage in Cancer and Neuroprotection

(2017) Caty Casas   Frontiers in Neuroscience

Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation

(2017) Christine Xue et al.   Royal Society Open Science

A phase I dose-escalation study of NKP-1339 in patients with advanced solid tumors refractory to treatment.

(2017) N. R. Dickson et al.   JOURNAL OF CLINICAL ONCOLOGY

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

(2016) Enzo Alessio   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides

(2016) Bruno Alies et al.   INORGANIC CHEMISTRY

Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A

(2016) Chiara Pelillo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism

(2016) Aleksandar Bijelic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amberlite IR-120(H)-mediated “on water” synthesis of novel anticancer ruthenium(ii)–p-cymene 2-pyridinylbenzothiazole (BTZ), 2-pyridinylbenzoxazole (BOZ) & 2-pyridinylbenzimidazole (BIZ) scaffolds

(2016) Sunisha Kottukulam Subran et al.   NEW JOURNAL OF CHEMISTRY

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression

(2016) Michael M. Lizardo et al.   NEOPLASIA

Albumin binding and ligand-exchange processes of the Ru(iii) anticancer agent NAMI-A and its bis-DMSO analogue determined by ENDOR spectroscopy

(2015) Michael I. Webb et al.   DALTON TRANSACTIONS

Modulation of the Aβ peptide aggregation pathway by KP1019 limits Aβ-associated neurotoxicity

(2015) Michael R. Jones et al.   Metallomics

Metal Ions and Intrinsically Disordered Proteins and Peptides: From Cu/Zn Amyloid-β to General Principles

(2014) Peter Faller et al.   ACCOUNTS OF CHEMICAL RESEARCH

Modulation of Amyloid-β Aggregation by Histidine-Coordinating Cobalt(III) Schiff Base Complexes

(2014) Marie C. Heffern et al.   CHEMBIOCHEM

Cationic triruthenium(III) oxo complexes of the type [Ru 3 O(OAc) 6 L 3 ] + containing imidazole, pyrazole, thiazole and oxazole ligands: Synthesis, molecular structure, and cytotoxicity

(2014) Jiří Tauchman et al.   INORGANICA CHIMICA ACTA

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

(2014) Suzanne Leijen et al.   INVESTIGATIONAL NEW DRUGS

Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease

(2014) Meng Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

The Aggregation Potential of the 1–15- and 1–16-Fragments of the Amyloid β Peptide and Their Influence on the Aggregation of Aβ40

(2013) M. Shabestari et al.   APPLIED MAGNETIC RESONANCE

Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide

(2013) Victor A. Streltsov et al.   CHEMICAL COMMUNICATIONS

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

(2013) Justin J. Wilson et al.   CHEMICAL REVIEWS

Biotransformations of Anticancer Ruthenium(III) Complexes: An X-Ray Absorption Spectroscopic Study

(2013) Aviva Levina et al.   CHEMISTRY-A EUROPEAN JOURNAL

EPR as a probe of the intracellular speciation of ruthenium(iii) anticancer compounds

(2013) Michael I. Webb et al.   Metallomics

Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult

(2013) William I. Rosenblum   NEUROBIOLOGY OF AGING

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Synthesis, characterization and X-ray crystal structures of ruthenium polypyridyl and 2-(2′-hydroxyphenyl)-benzoxazole complexes: Reactivity with 1-methylimidazole, purine, glutathione and CT-DNA

(2013) John Novales et al.   POLYHEDRON

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex

(2013) Luigi Messori et al.   ACS Medicinal Chemistry Letters

Facile Methodology for Monitoring Amyloid-β Fibrillization

(2012) Nathan P. Cook et al.   ACS Chemical Neuroscience

Dye-Binding Assays for Evaluation of the Effects of Small Molecule Inhibitors on Amyloid (Aβ) Self-Assembly

(2012) Laramie P. Jameson et al.   ACS Chemical Neuroscience

The influence of lipophilicity in drug discovery and design

(2012) John A Arnott et al.   Expert Opinion on Drug Discovery

A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines

(2012) Werner Ginzinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Control of ligand-exchange processes and the oxidation state of the antimetastatic Ru(iii) complex NAMI-A by interactions with human serum albumin

(2011) Michael I. Webb et al.   DALTON TRANSACTIONS

Pyridine Analogues of the Antimetastatic Ru(III) Complex NAMI-A Targeting Non-Covalent Interactions with Albumin

(2011) Michael I. Webb et al.   INORGANIC CHEMISTRY

Approaching tumour therapy beyond platinum drugs

(2011) A. Bergamo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Ru(η6-arene) complexes of combretastatin-analogous oxazoles with enhanced anti-tumoral impact

(2010) Bernhard Biersack et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

fac-{Ru(CO)3}2+Selectively Targets the Histidine Residues of the β-Amyloid Peptide 1-28. Implications for New Alzheimer's Disease Treatments Based on Ruthenium Complexes

(2010) Daniela Valensin et al.   INORGANIC CHEMISTRY

Oxidative Cyclization of a Phenolic Schiff Base and Synthesis of a Cyclometalated Ruthenium Nitrosyl Complex: Photoinduced NO Release by Visible Light

(2010) Kaushik Ghosh et al.   INORGANIC CHEMISTRY

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

(2010) Petra Heffeter et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Amyloid fibrils

(2010) Roma N. Rambaran et al.   Prion

Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

(2009) Frederike Lentz et al.   ANTI-CANCER DRUGS

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

(2008) Christian G. Hartinger et al.   CHEMISTRY & BIODIVERSITY

Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes

(2008) By Jan Reedijk  

The dichotomy in the DNA-binding behaviour of ruthenium(II) complexes bearing benzoxazole and benzothiazole groups

(2007) Catriona B. Spillane et al.   JOURNAL OF INORGANIC BIOCHEMISTRY