8-Hydroxyquinoline ruthenium(II) complexes induce ferroptosis in HeLa cells by down-regulating GPX4 and ferritin

Anticancer activity of ruthenium(II) plumbagin complexes with polypyridyl as ancillary ligands via inhibiting energy metabolism and GADD45A-mediated cell cycle arrest

(2022) Yu-Lan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Lysosome-targeted ruthenium(II) complexes induce both apoptosis and autophagy in HeLa cells

(2022) Nan-Lian Pan et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes

(2022) Xiurong Ma et al.   Frontiers in Chemistry

Synthesis, X-ray diffraction and anti-proliferative biological activity of hispolon derivatives and their (η6-p-cymene)(Hispolonato)Ruthenium[II] chloride complexes

(2022) Francesco Caruso et al.   INORGANICA CHIMICA ACTA

The role of Platinum(IV)-based antitumor drugs and the anticancer immune response in medicinal inorganic chemistry. A systematic review from 2017 to 2022

(2022) Shihao Su et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis

(2021) Faisal Thayyullathil et al.   Cell Death & Disease

Cyclometalated iridium(III) complexes as mitochondria-targeted anticancer and antibacterial agents to induce both autophagy and apoptosis

(2021) Bing-Bing Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis

(2021) Ruonan Zhang et al.   Bioactive Materials

SnapShot: Ferroptosis

(2020) Kamyar Hadian et al.   CELL

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

Zebrafish as a model for inflammation and drug discovery

(2020) Rodrigo Zanandrea et al.   DRUG DISCOVERY TODAY

Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications

(2020) Liyuan Cao et al.   PHARMACOLOGICAL RESEARCH

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Reactive oxygen species and cancer: A complex interaction

(2019) Sankaralingam Saikolappan et al.   CANCER LETTERS

Protective effects of Platycodon grandiflorus polysaccharides against apoptosis induced by carbonyl cyanide 3-chlorophenylhydrazone in 3D4/21 cells

(2019) Cheng Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Discovery of novel halogenated 8‐hydroxyquinoline‐based anti‐MRSA agents: In vitro and QSAR studies

(2019) Rungrot Cherdtrakulkiat et al.   DRUG DEVELOPMENT RESEARCH

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

(2019) Giovanni Miotto et al.   Redox Biology

Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins

(2018) Silvia Alonso-de Castro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate

(2018) Jing Yang et al.   BIOMATERIALS

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Harnessing ruthenium(II) as photodynamic agents: Encouraging advances in cancer therapy

(2018) Jiangping Liu et al.   COORDINATION CHEMISTRY REVIEWS

Cyclometalated iridium(iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth in vivo

(2018) Liang He et al.   DALTON TRANSACTIONS

Synthesis and characterization of ruthenium(III) complex containing 2-aminomethyl benzimidazole, and its anticancer activity of in vitro and in vivo models

(2018) H.A. Sahyon et al.   JOURNAL OF MOLECULAR LIQUIDS

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of anti-apoptotic drug Z-VAD-FMK on in vitro viability of dog follicles

(2018) Leda Maria Costa Pereira et al.   THERIOGENOLOGY

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

(2018) Xinbing Sui et al.   Frontiers in Pharmacology

Applications of Ruthenium Complex in Tumor Diagnosis and Therapy

(2018) Ke Lin et al.   Frontiers in Pharmacology

Synthesis, characterization, cellular uptake and apoptosis-inducing properties of two highly cytotoxic cyclometalated ruthenium(II) β-carboline complexes

(2017) Jincan Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status

(2017) Mohamed Wehbe et al.   INVESTIGATIONAL NEW DRUGS

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Studies on the structures, cytotoxicity and apoptosis mechanism of 8-hydroxylquinoline rhodium(iii) complexes in T-24 cells

(2016) Hai-Rong Zhang et al.   NEW JOURNAL OF CHEMISTRY

Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents

(2015) Yi Li et al.   BIOMATERIALS

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

Zebrafish embryos and larvae: A new generation of disease models and drug screens

(2011) Shaukat Ali et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Synthesis and structure-activity relationship study of 8-hydroxyquinoline-derived Mannich bases as anticancer agents

(2010) Arthur Y. Shaw et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring the cellular accumulation of metal complexes

(2009) Cindy A. Puckett et al.   DALTON TRANSACTIONS

Zebrafish embryos as models for embryotoxic and teratological effects of chemicals

(2009) Lixin Yang et al.   REPRODUCTIVE TOXICOLOGY

Study on temperature characteristics of organic light-emitting diodes based on tris-(8-hydroxylquinoline)-aluminum

(2008) Fan Suo et al.   CHINESE SCIENCE BULLETIN