Anticancer activity of ruthenium(II) plumbagin complexes with polypyridyl as ancillary ligands via inhibiting energy metabolism and GADD45A-mediated cell cycle arrest

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Glycolysis

(2021) Navdeep S. Chandel   Cold Spring Harbor Perspectives in Biology

Iso-suillin-induced DNA damage leading to cell cycle arrest and apoptosis arised from p53 phosphorylation in A549 cells

(2021) Yongxin Yan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Connections between the Cell Cycle and the DNA Damage Response in Plants

(2021) Naomie Gentric et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemodynamic therapy agents Cu(II) complexes of quinoline derivatives induced ER stress and mitochondria-mediated apoptosis in SK-OV-3 cells

(2021) Wen-Ying Shen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Characterization, Cytotoxic Activity, and Metabolic Studies of Ruthenium(II) Polypyridyl Complexes Containing Flavonoid Ligands

(2020) Alexandra-Cristina Munteanu et al.   INORGANIC CHEMISTRY

Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies

(2020) Anna Notaro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of poly (ADP-ribose) polymerase-1 in cadmium-induced cellular DNA damage and cell cycle arrest in rat renal tubular epithelial cell line NRK-52E

(2020) Tongwang Luo et al.   ENVIRONMENTAL POLLUTION

Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent

(2020) Xing Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Mitochondrial Ca2+ Uptake and the Fine-Tuning of Aerobic Metabolism

(2020) Gaia Gherardi et al.   Frontiers in Physiology

Mitochondria as a Novel Target for Cancer Chemoprevention: Emergence of Mitochondrial Targeting Agents

(2020) Mofei Huang et al.   Cancer Prevention Research

New copper complexes inducing bimodal death through apoptosis and autophagy in A549 cancer cells

(2020) Noor Shad Gul et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Anticancer Cyclometalated Iridium(III) Complexes with Planar Ligands: Mitochondrial DNA Damage and Metabolism Disturbance

(2019) Jian-Jun Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Restraining Cancer Cells by Dual Metabolic Inhibition with a Mitochondrion-Targeted Platinum(II) Complex

(2019) Kun Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of β-carboline copper(II) complexes as Mcl-1 inhibitor and in vitro and in vivo activity in cancer models

(2019) Xing Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

GADD45a Mediated Cell Cycle Inhibition Is Regulated By P53 In Bladder Cancer

(2019) Na Han et al.   OncoTargets and Therapy

Anticancer Activity of Platinum (II) Complex with 2-Benzoylpyridine by Induction of DNA Damage, S-Phase Arrest, and Apoptosis

(2019) Yu-Lan Li et al.   Anti-Cancer Agents in Medicinal Chemistry

Cell death mechanisms in eukaryotes

(2019) J. Grace Nirmala et al.   CELL BIOLOGY AND TOXICOLOGY

Histone Lactylation: A New Role for Glucose Metabolism

(2019) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?

(2019) Sherri A. McFarland et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biological applications of Ru(II) polypyridyl complexes

(2018) Mariusz Mital et al.   COORDINATION CHEMISTRY REVIEWS

Integrating DNA damage repair with the cell cycle

(2018) Johanne M Murray et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondria-targeted platinum(II) complexes induce apoptosis-dependent autophagic cell death mediated by ER-stress in A549 cancer cells

(2018) Feng-Yang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway

(2018) Gangjun Yuan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma

(2018) Zhi-qiang Yao et al.   Cell Death & Disease

Down-regulation of GADD45A enhances chemosensitivity in melanoma

(2018) Jia Liu et al.   Scientific Reports

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

(2018) Sandra M. Hill et al.   CELL DEATH AND DIFFERENTIATION

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433

(2018) Susan Monro et al.   CHEMICAL REVIEWS

GADD45a Regulates Olaquindox-Induced DNA Damage and S-Phase Arrest in Human Hepatoma G2 Cells via JNK/p38 Pathways

(2017) Daowen Li et al.   MOLECULES

Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(iii) complexes

(2017) Jian-Jun Cao et al.   Chemical Science

Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction

(2016) Daowen Li et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival

(2016) Susanne Wingert et al.   STEM CELLS

PINK1/Parkin-mediated mitophagy play a protective role in manganese induced apoptosis in SH-SY5Y cells

(2016) Hong-Tao Zhang et al.   TOXICOLOGY IN VITRO

Synthesis of four binuclear copper(II) complexes: Structure, anticancer properties and anticancer mechanism

(2015) Jinxu Qi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Folate-functionalized human serum albumin carrier for anticancer copper(II) complexes derived from natural plumbagin

(2015) Yi Gou et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Water-Soluble Ruthenium(II) Complexes with Chiral 4-(2,3-Dihydroxypropyl)-formamide Oxoaporphine (FOA): In Vitro and in Vivo Anticancer Activity by Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Induction of Tumor Cell Apoptosis

(2015) Zhen-Feng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

(2014) Suzanne Leijen et al.   INVESTIGATIONAL NEW DRUGS

Ferrocene and (arene)ruthenium(II) complexes of the natural anticancer naphthoquinone plumbagin with enhanced efficacy against resistant cancer cells and a genuine mode of action

(2014) Cornelia Spoerlein-Guettler et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Gadd45a Suppresses Tumor Angiogenesis via Inhibition of the mTOR/STAT3 Protein Pathway

(2013) Fang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Localized Iridium(III) Complex Induces Endoplasmic Reticulum Stress and Mitochondria-Mediated Apoptosis in Human Cancer Cells

(2013) Rui Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

GADD45 Proteins: Central Players in Tumorigenesis

(2012) R. E. Tamura et al.   CURRENT MOLECULAR MEDICINE

The Warburg effect: Insights from the past decade

(2012) Mohita Upadhyay et al.   PHARMACOLOGY & THERAPEUTICS

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Antioxidant Activities of Plumbagin and Its Cu (II) Complex

(2011) Mingxiong Tan et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Correction: Gadd45a Functions as a Promoter or Suppressor of Breast Cancer Dependent on the Oncogenic Stress

(2011)   CANCER RESEARCH

Oligonuclear polypyridylruthenium(ii) complexes incorporating flexible polar and non-polar bridges: synthesis, DNA-binding and cytotoxicity

(2011) Yanyan Mulyana et al.   DALTON TRANSACTIONS

Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes

(2011) Caiping Tan et al.   DALTON TRANSACTIONS

Approaching tumour therapy beyond platinum drugs

(2011) A. Bergamo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Interaction Between Plumbagin and Human Serum Albumin by Fluorescence Spectroscopy

(2011) Shuang Li et al.   JOURNAL OF SOLUTION CHEMISTRY

Two-phase dynamics of p53 in the DNA damage response

(2011) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioenergetic characterization of mouse podocytes

(2010) Yoshifusa Abe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells

(2010) Tianfeng Chen et al.   INORGANIC CHEMISTRY

Synthesis, characterization and preliminary cytotoxicity evaluation of five Lanthanide(III)–Plumbagin complexes

(2010) Zhen-Feng Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis

(2010) Caiping Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neutral and Dianionic Ru(II) Bathophenanthrolinedisulfonate Complexes: A Route To Enhance Electrochemiluminescence Performance in Aqueous Media

(2010) Leopoldo Della Ciana et al.   Journal of Physical Chemistry C

Perspectives on medicinal properties of plumbagin and its analogs

(2010) Subhash Padhye et al.   MEDICINAL RESEARCH REVIEWS

Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

(2009) Frederike Lentz et al.   ANTI-CANCER DRUGS

Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry

(2009) Zhen-Feng Chen et al.   DALTON TRANSACTIONS