Cyclometalated iridium(III) complexes as mitochondria-targeted anticancer and antibacterial agents to induce both autophagy and apoptosis

Insight into antimicrobial activity of substituted phenylcarbamoyloxypiperazinylpropanols

(2020) Sarka Pospisilova et al.   BIOORGANIC CHEMISTRY

Anticancer Cyclometalated Iridium(III) Complexes with Planar Ligands: Mitochondrial DNA Damage and Metabolism Disturbance

(2019) Jian-Jun Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Guanidine-modified cyclometalated iridium(III) complexes for mitochondria-targeted imaging and photodynamic therapy

(2019) Xing-Dong Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metal complexes for mitochondrial bioimaging

(2019) Ruilin Guan et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Design, synthesis and biological evaluation of iridium(III) complexes as potential antitumor agents

(2019) Fan Du et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis, photophysical and anticancer properties of mitochondria-targeted phosphorescent cyclometalated iridium(III) N-heterocyclic carbene complexes

(2019) Yi Li et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mitochondrial dynamics tracking with iridium(III) complexes

(2018) Yu Chen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cyclometalated iridium(iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth in vivo

(2018) Liang He et al.   DALTON TRANSACTIONS

Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Containing P^P-Chelating Ligands: A New Class of Potent Anticancer Agents with Unusual Redox Features

(2018) JuanJuan Li et al.   INORGANIC CHEMISTRY

The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis

(2018) Guojian Liao et al.   Polymers

Anticancer and antibacterial activity in vitro evaluation of iridium(III) polypyridyl complexes

(2018) Qiao-Yan Yi et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Sasanquasaponin ΙΙΙ from Schima crenata Korth induces autophagy through Akt/mTOR/p70S6K pathway and promotes apoptosis in human melanoma A375 cells

(2018) Qiu Ping Liang et al.   PHYTOMEDICINE

Quercetin alleviates high glucose-induced damage on human umbilical vein endothelial cells by promoting autophagy

(2018) Aysa Rezabakhsh et al.   PHYTOMEDICINE

Purple sweet potato color protects against high-fat diet-induced cognitive deficits through AMPK-mediated autophagy in mouse hippocampus

(2018) Juan Zhuang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cyclometalated iridium(III)-guanidinium complexes as mitochondria-targeted anticancer agents

(2017) Xing-Dong Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

(2017) Leore T. Geller et al.   SCIENCE

Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes

(2017) V. Venkatesh et al.   Chemical Science

Autophagy and its implication in human oral diseases

(2016) Ya-Qin Tan et al.   Autophagy

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Modes of invasion during tumour dissemination

(2016) Pahini Pandya et al.   Molecular Oncology

Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease

(2015) Jeong-A Lim et al.   Autophagy

Direct imaging of biological sulfur dioxide derivatives in vivo using a two-photon phosphorescent probe

(2015) Guanying Li et al.   BIOMATERIALS

Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart

(2015) T. Saito et al.   CIRCULATION RESEARCH

Cyclometalated iridium(iii) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents

(2015) Liang He et al.   Chemical Science

Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

(2015) Lihua Lu et al.   Scientific Reports

Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity

(2015) Lihua Lu et al.   Scientific Reports

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts

(2014) Zhe Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Autophagy is essential for cardiac morphogenesis during vertebrate development

(2014) Eunmyong Lee et al.   Autophagy

c-Jun NH2-terminal kinase-induced proteasomal degradation of c-FLIPL/S and Bcl2 sensitize prostate cancer cells to Fas- and mitochondria-mediated apoptosis by tetrandrine

(2014) Pankaj Chaudhary et al.   BIOCHEMICAL PHARMACOLOGY

Cyclometalated Ir(iii) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy

(2014) Rui-Rong Ye et al.   CHEMICAL COMMUNICATIONS

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antitumor properties and mechanisms of mitochondria-targeted Ag(i) and Au(i) complexes containing N-heterocyclic carbenes derived from cyclophanes

(2014) Yi Li et al.   Metallomics

Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on probe

(2014) Lihua Lu et al.   Chemical Science

Rational Design of Nanoparticles with Efficient Lanthanide Luminescence Sensitized by Iridium(III) Complex for Time-Gated Luminescence Bioimaging

(2014) Qiang Zhao et al.   Advanced Optical Materials

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

(2013) G C Higgins et al.   BRITISH JOURNAL OF PHARMACOLOGY

Membrane Localized Iridium(III) Complex Induces Endoplasmic Reticulum Stress and Mitochondria-Mediated Apoptosis in Human Cancer Cells

(2013) Rui Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autophagy-regulating small molecules and their therapeutic applications

(2012) Kyung-Hwa Baek et al.   CHEMICAL SOCIETY REVIEWS

Anticancer Activity of Silver-N-Heterocyclic Carbene Complexes: Caspase-Independent Induction of Apoptosis via Mitochondrial Apoptosis-Inducing Factor (AIF)

(2012) Laure Eloy et al.   ChemMedChem

Phosphorescent heavy-metal complexes for bioimaging

(2011) Qiang Zhao et al.   CHEMICAL SOCIETY REVIEWS

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

(2011) Li Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphorescent Sensor for Robust Quantification of Copper(II) Ion

(2011) Youngmin You et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY