Synthesis, X-ray diffraction and anti-proliferative biological activity of hispolon derivatives and their (η6-p-cymene)(Hispolonato)Ruthenium[II] chloride complexes

Utilization of Guanidine-Based Ancillary Ligands in Arene–Ruthenium Complexes for Selective Cytotoxicity

(2021) Jit Karmakar et al.   ACS Omega

The Role of Iron in Cancer Progression

(2021) Qianqian Guo et al.   Frontiers in Oncology

Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells

(2020) Luca Quattrini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/β-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis

(2020) Hueng-Chuen Fan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

X-ray crystal structures, density functional theory and docking on deacetylase enzyme for antiproliferative activity of hispolon derivatives on HCT116 colon cancer

(2019) Miriam Rossi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium(II) complexes of hispolon derivatives

(2019) Xiaonan Wei et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Half-Sandwich Metal Complexes with β-Diketone-Like Ligands and Their Anticancer Activity

(2018) Riccardo Pettinari et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Anticancer Activity of Bifunctional Organometallic Ru(II) Arene Complexes Containing a 7-Hydroxycoumarin Group

(2018) Jian Zhao et al.   ORGANOMETALLICS

Effects of hispolon on glioblastoma cell growth

(2017) Antonietta Arcella et al.   ENVIRONMENTAL TOXICOLOGY

New highly cytotoxic organic and organometallic bexarotene derivatives

(2017) Yulia N. Nosova et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Water soluble Ru(ii)–arene complexes of the antidiabetic drug metformin: DNA and protein binding, molecular docking, cytotoxicity and apoptosis-inducing activity

(2017) Durairaj Gopalakrishnan et al.   RSC Advances

The in vitro antitumor activity of arene-ruthenium(II) curcuminoid complexes improves when decreasing curcumin polarity

(2016) Francesco Caruso et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Design, synthesis and in vitro cell-based evaluation of the anti-cancer activities of hispolon analogs

(2015) Neduri V. Balaji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Half-Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells

(2015) Maria V. Babak et al.   CHEMISTRY-A EUROPEAN JOURNAL

The anticancer effects of hispolon on lung cancer cells

(2014) Qiuge Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis, Characterization, and Antitumor Activity of Water-Soluble (Arene)ruthenium(II) Derivatives of 1,3-Dimethyl-4-acylpyrazolon-5-ato Ligands. First Example of Ru(arene)(ligand) Antitumor Species Involving Simultaneous Ru–N7(guanine) Bonding and Ligand Intercalation to DNA

(2014) Francesco Caruso et al.   INORGANIC CHEMISTRY

Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3, -8 and -9

(2014) Yi-Shyan Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hispolon from Phellinus linteus possesses mediate caspases activation and induces human nasopharyngeal carcinomas cells apoptosis through ERK1/2, JNK1/2 and p38 MAPK pathway

(2014) Ming-Ju Hsieh et al.   PHYTOMEDICINE

Detection and confirmation of hispolon in the mushroom Phellinus linteus

(2014) Padungrat Toopmuang et al.   SCIENCEASIA

Hispolon from Phellinus linteus Induces G0/G1 Cell Cycle Arrest and Apoptosis in NB4 Human Leukaemia Cells

(2013) Yi-Chuan Chen et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes

(2012) Isolda Romero-Canelón et al.   Metallomics

Hispolon Induces Apoptosis and Cell Cycle Arrest of Human Hepatocellular Carcinoma Hep3B Cells by Modulating ERK Phosphorylation

(2011) Guan-Jhong Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ruthenium–Arene Complexes of Curcumin: X-Ray and Density Functional Theory Structure, Synthesis, and Spectroscopic Characterization, in Vitro Antitumor Activity, and DNA Docking Studies of (p-Cymene)Ru(curcuminato)chloro

(2011) Francesco Caruso et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hispolon Suppresses SK-Hep1 Human Hepatoma Cell Metastasis by Inhibiting Matrix Metalloproteinase-2/9 and Urokinase-Plasminogen Activator through the PI3K/Akt and ERK Signaling Pathways

(2010) Guan-Jhong Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway

(2008) Wei Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE