The Polyanionic Drug Suramin Neutralizes Histones and Prevents Endotheliopathy

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

(2021) Ramu Manjula et al.   Frontiers in Pharmacology

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality

(2021) Rebecca J. Shaw et al.   HAEMATOLOGICA

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

(2021)   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

(2021)   NEW ENGLAND JOURNAL OF MEDICINE

Treating the endotheliopathy of SARS‐CoV ‐2 infection with plasma: Lessons learned from optimized trauma resuscitation with blood products

(2021) Shibani Pati et al.   TRANSFUSION

A computational study of cooperative binding to multiple SARS-CoV-2 proteins

(2021) Jianing Li et al.   Scientific Reports

Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

(2021) Zdravka Daneva et al.   eLife

Platelets amplify endotheliopathy in COVID-19

(2021) Tessa J. Barrett et al.   Science Advances

Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide

(2021) Hui Shi et al.   JCI Insight

Increased histone-DNA complexes and endothelial-dependent thrombin generation in severe COVID-19

(2021) Beth A. Bouchard et al.   VASCULAR PHARMACOLOGY

Covid-19: trials of four potential treatments to generate “robust data” of what works

(2020) Anna Sayburn   BMJ-British Medical Journal

Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4

(2020) Theodora-Dorita Tsourouktsoglou et al.   Cell Reports

Extracellular Histone H3 Induces Pyroptosis During Sepsis and May Act Through NOD2 and VSIG4/NLRP3 Pathways

(2020) Chun-xia Shi et al.   Frontiers in Cellular and Infection Microbiology

Bioactive DNA from extracellular vesicles and particles

(2020) Ethan Z. Malkin et al.   Cell Death & Disease

Site-specific opening of the blood-brain barrier by extracellular histones

(2020) Nuria Villalba et al.   Journal of Neuroinflammation

The Use of cyclodextrin or its complexes as a potential treatment against the 2019 novel coronavirus. A mini-review.

(2020) Fatmi Sofiane et al.   Current Drug Delivery

Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge–Mediated Monocyte Adhesion

(2020) Ariane Schumski et al.   CIRCULATION

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

(2020) Sean X. Gu et al.   Nature Reviews Cardiology

Neutralizing the pathological effects of extracellular histones with small polyanions

(2020) Connor H. O’ Meara et al.   Nature Communications

Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation

(2019) Daniel M Collier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

(2019) Carlos Silvestre-Roig et al.   NATURE

Metabolic Systems Analysis of Shock-Induced Endotheliopathy (SHINE) in Trauma

(2019) Hanne H. Henriksen et al.   ANNALS OF SURGERY

Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage

(2019) Paul Vulliamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Citrullinated histone 3 causes endothelial barrier dysfunction

(2018) Jamie E. Meegan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone-Complexed DNA Fragments Levels are Associated with Coagulopathy, Endothelial Cell Damage, and Increased Mortality after Severe Pediatric Trauma

(2018) Robert T. Russell et al.   SHOCK

Endotheliopathy of Trauma is an on-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome

(2018) David N. Naumann et al.   SHOCK

Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI

(2017) Daigo Nakazawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study

(2017) David N. Naumann et al.   PLoS One

The role of extracellular histone in organ injury

(2017) Eleanor Silk et al.   Cell Death & Disease

Histones stimulate von Willebrand factor release in vitro and in vivo

(2016) F. W. Lam et al.   HAEMATOLOGICA

Histones Induce the Procoagulant Phenotype of Endothelial Cells through Tissue Factor Up-Regulation and Thrombomodulin Down-Regulation

(2016) Ji Eun Kim et al.   PLoS One

Extracellular histones induce tissue factor expression in vascular endothelial cells via TLR and activation of NF-κB and AP-1

(2016) Xinyu Yang et al.   THROMBOSIS RESEARCH

Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation

(2016) Gerben Marsman et al.   Cell Death & Disease

Histones stimulate von Willebrand factor release in vitro and in vivo

(2016) F. W. Lam et al.   HAEMATOLOGICA

Extracellular Histones Play an Inflammatory Role in Acid Aspiration-induced Acute Respiratory Distress Syndrome

(2015) Yanlin Zhang et al.   ANESTHESIOLOGY

Melittin Aggregation in Aqueous Solutions: Insight from Molecular Dynamics Simulations

(2015) Chenyi Liao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Thrombotic Role of Blood and Endothelial Cells in Uremia through Phosphatidylserine Exposure and Microparticle Release

(2015) Chunyan Gao et al.   PLoS One

Suppression of cell membrane permeability by suramin: involvement of its inhibitory actions on connexin 43 hemichannels

(2014) Yuan Chi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development

(2014) A. S. Savchenko et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis

(2014) K. Daigo et al.   Science Signaling

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

(2013) A. S. Savchenko et al.   BLOOD

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

(2013) K. C. A. A. Wildhagen et al.   BLOOD

Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs

(2013) G R Wickman et al.   CELL DEATH AND DIFFERENTIATION

Histones trigger sterile inflammation by activating the NLRP3 inflammasome

(2013) Ramanjaneyulu Allam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Histone induced platelet aggregation is inhibited by normal albumin

(2013) Fong W. Lam et al.   THROMBOSIS RESEARCH

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Extracellular histone release in response to traumatic injury

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Elementary Ca2+ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

(2012) S. K. Sonkusare et al.   SCIENCE

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Histones interact with anionic phospholipids with high avidity; its relevance for the binding of histone-antihistone immune complexes

(2010) L. F. PEREIRA et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)*

(2009) Fabián Jaimes et al.   CRITICAL CARE MEDICINE

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE