Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage

Microparticles profiling in trauma patients: high level of microparticles induce activation of platelets in vitro

(2019) Michael Caspers et al.   European Journal of Trauma and Emergency Surgery

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

(2019) Carlos Silvestre-Roig et al.   NATURE

Data-driven Development of ROTEM and TEG Algorithms for the Management of Trauma Hemorrhage

(2018) Kjersti Baksaas-Aasen et al.   ANNALS OF SURGERY

Hemorrhagic Shock

(2018) Jeremy W. Cannon   NEW ENGLAND JOURNAL OF MEDICINE

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis

(2018) Norma Maugeri et al.   Science Translational Medicine

Platelet dysfunction during trauma involves diverse signaling pathways and an inhibitory activity in patient-derived plasma

(2018) Christopher C. Verni et al.   Journal of Trauma and Acute Care Surgery

Platelets as autonomous drones for hemostatic and immune surveillance

(2017) Jackson LiangYao Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impact of blood products on platelet function in patients with traumatic injuries: a translational study

(2017) Hanne Hee Henriksen et al.   JOURNAL OF SURGICAL RESEARCH

Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage

(2017) Paul Vulliamy et al.   Journal of Trauma and Acute Care Surgery

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

(2017) Yuping Yuan et al.   Science Translational Medicine

Targeted clinical control of trauma patient coagulation through a thrombin dynamics model

(2017) Amor A. Menezes et al.   Science Translational Medicine

Membrane Ballooning in Aggregated Platelets is Synchronised and Mediates a Surge in Microvesiculation

(2017) Ejaife O. Agbani et al.   Scientific Reports

Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage

(2017) Paul Vulliamy et al.   Journal of Trauma and Acute Care Surgery

Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting

(2016) N. A. Podoplelova et al.   BLOOD

Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial

(2016) M Irem Baharoglu et al.   LANCET

Coordinated Membrane Ballooning and Procoagulant Spreading in Human PlateletsClinical Perspective

(2015) Ejaife O. Agbani et al.   CIRCULATION

The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013

(2015) Juanita A Haagsma et al.   INJURY PREVENTION

Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma

(2015) John B. Holcomb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Endogenous Microparticles Drive the Proinflammatory Host Immune Response in Severely Injured Trauma Patients

(2015) Kirsten Balvers et al.   SHOCK

FLow-Induced PRotrusions (FLIPRs)

(2014) Claudia Tersteeg et al.   CIRCULATION RESEARCH

Release and activity of histone in diseases

(2014) R Chen et al.   Cell Death & Disease

Functional responses and molecular mechanisms involved in histone-mediated platelet activation

(2013) Marìa Albertina Romaniuk et al.   THROMBOSIS AND HAEMOSTASIS

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Characterization of platelet dysfunction after trauma

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Trauma alarmins as activators of damage-induced inflammation

(2011) J. Manson et al.   BRITISH JOURNAL OF SURGERY

Functional definition and characterization of acute traumatic coagulopathy

(2011) Ross Davenport et al.   CRITICAL CARE MEDICINE

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

(2011) Hai Huang et al.   HEPATOLOGY

Platelet function following trauma

(2011) Cristina Solomon et al.   THROMBOSIS AND HAEMOSTASIS

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

(2009) Mark R. Looney et al.   JOURNAL OF CLINICAL INVESTIGATION

TRANSFUSION PRACTICE: Thrombin generation in trauma patients

(2009) Nancy M. Dunbar et al.   TRANSFUSION