Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7

Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7

(2023) Goragot Wisedchaisri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV

(2022) Gaoxingyu Huang et al.   Cell Reports

Sodium Channelopathies of Skeletal Muscle and Brain

(2021) Massimo Mantegazza et al.   PHYSIOLOGICAL REVIEWS

Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin

(2020) Goragot Wisedchaisri et al.   MOLECULAR CELL

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

(2019) Hui Xu et al.   CELL

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics

(2019) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel

(2019) Goragot Wisedchaisri et al.   CELL

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb

(2018) Tamer M. Gamal El-Din et al.   JOURNAL OF GENERAL PHYSIOLOGY

The chemical basis for electrical signaling

(2017) William A Catterall et al.   Nature Chemical Biology

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling

(2016) Paul Geha et al.   JAMA Neurology

The hitchhiker’s guide to the voltage-gated sodium channel galaxy

(2015) Christopher A. Ahern et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

(2015) S. Ahuja et al.   SCIENCE

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels

(2015) Mohamed-Yassine Amarouch et al.   Frontiers in Physiology

Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias

(2014) H. Swan et al.   Circulation-Cardiovascular Genetics

Sodium channel genes in pain-related disorders: phenotype–genotype associations and recommendations for clinical use

(2014) Stephen G Waxman et al.   LANCET NEUROLOGY

Translational pain research: Lessons from genetics and genomics

(2014) S. D. Dib-Hajj et al.   Science Translational Medicine

A Novel SCN9A Mutation Responsible for Primary Erythromelalgia and Is Resistant to the Treatment of Sodium Channel Blockers

(2013) Min-Tzu Wu et al.   PLoS One

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation

(2010) M. Estacion et al.   JOURNAL OF PHYSIOLOGY-LONDON

Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials

(2009) Angelika Lampert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutation I136V Alters Electrophysiological Properties of the NaV1.7 Channel in a Family with Onset of Erythromelalgia in the Second Decade

(2008) Xiaoyang Cheng et al.   Molecular Pain

A novel dominant mutation of the Nav1.4  -subunit domain I leading to sodium channel myotonia

(2008) S. Petitprez et al.   NEUROLOGY