Multiphysics modeling and simulation of local transport and absorption kinetics of intramuscularly injected lipid nanoparticles

Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine

(2022) Hiromi Muramatsu et al.   MOLECULAR THERAPY

Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size

(2022) Jiaxing Di et al.   PHARMACEUTICAL RESEARCH

Size‐Selective Transfer of Lipid Nanoparticle‐Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury

(2022) Igor Khalin et al.   Small

Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) on Nanoparticle Formulation: Implications for COVID-19 Vaccines

(2022) Esperanza Padín-González et al.   Frontiers in Bioengineering and Biotechnology

Transport and distribution of biotherapeutics in different tissue layers after subcutaneous injection

(2022) Ehsan Rahimi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion

(2022) Nima Aliakbarinodehi et al.   ACS Nano

Nanosac, a Noncationic and Soft Polyphenol Nanocapsule, Enables Systemic Delivery of siRNA to Solid Tumors

(2021) Hyungjun Kim et al.   ACS Nano

Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives

(2021) Zimei Wu et al.   PHARMACEUTICAL RESEARCH

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

(2021) Linde Schoenmaker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Model Development

(2021) Fudan Zheng et al.   PHARMACEUTICAL RESEARCH

Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

(2021) Rumiana Tenchov et al.   ACS Nano

Multiscale pharmacokinetic modeling of systemic exposure of subcutaneously injected biotherapeutics

(2021) Fudan Zheng et al.   JOURNAL OF CONTROLLED RELEASE

Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Sensitivity Analysis

(2021) Peng Hou et al.   PHARMACEUTICAL RESEARCH

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

(2021) Manuel J. Carrasco et al.   Communications Biology

Targeting drug delivery in the vascular system: Focus on endothelium

(2020) Patrick M. Glassman et al.   ADVANCED DRUG DELIVERY REVIEWS

When liposomes met antibodies: Drug delivery and beyond

(2020) Jiaxing Di et al.   ADVANCED DRUG DELIVERY REVIEWS

Properties of rapamycin solid lipid nanoparticles for lymphatic access through the lungs & part I: the effect of size

(2020) Emelie Landh et al.   Nanomedicine

On the characterization of interstitial fluid flow in the skeletal muscle endomysium

(2019) Qiuyun Wang et al.   Journal of the Mechanical Behavior of Biomedical Materials

Polymer‐mediated gene therapy: Recent advances and merging of delivery techniques

(2019) Janelle W. Salameh et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Porosity–Permeability Relations for Evolving Pore Space: A Review with a Focus on (Bio-)geochemically Altered Porous Media

(2018) Johannes Hommel et al.   TRANSPORT IN POROUS MEDIA

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

A case for poroelasticity in skeletal muscle finite element analysis: experiment and modeling

(2016) Benjamin B. Wheatley et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Skeletal muscle tensile strain dependence: Hyperviscoelastic nonlinearity

(2016) Benjamin B. Wheatley et al.   Journal of the Mechanical Behavior of Biomedical Materials

Pharmacologic Studies of a Prodrug of Mitomycin C in Pegylated Liposomes (Promitil®): High Stability in Plasma and Rapid Thiolytic Prodrug Activation in Tissues

(2015) Yasmine Amitay et al.   PHARMACEUTICAL RESEARCH

Single-cell mRNA transfection studies: Delivery, kinetics and statistics by numbers

(2013) Carolin Leonhardt et al.   Nanomedicine-Nanotechnology Biology and Medicine

Modelling the lymphatic system: challenges and opportunities

(2012) K. N. Margaris et al.   Journal of the Royal Society Interface

Quantitative model for predicting lymph formation and muscle compressibility in skeletal muscle during contraction and stretch

(2012) L. Causey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymphatic fluid: exchange mechanisms and regulation

(2011) Virginia H. Huxley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Modeling Concentration Distribution and Deformation During Convection-Enhanced Drug Delivery into Brain Tissue

(2011) Karen H. Støverud et al.   TRANSPORT IN POROUS MEDIA

Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix

(2010) Rolf K. Reed et al.   CARDIOVASCULAR RESEARCH

Intramuscular drug transport under mechanical loading: Resonance between tissue function and uptake

(2009) Peter I. Wu et al.   JOURNAL OF CONTROLLED RELEASE