Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion

Delivery of RNA Therapeutics: The Great Endosomal Escape!

(2022) Steven F. Dowdy et al.   Nucleic Acid Therapeutics

Nucleic Acid-Loaded Lipid Nanoparticle Interactions with Model Endosomal Membranes

(2022) Alice Spadea et al.   ACS Applied Materials & Interfaces

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

(2021) Federica Sebastiani et al.   ACS Nano

Intracellular mRNA transport and localized translation

(2021) Sulagna Das et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles

(2021) Jeremy P. Bost et al.   ACS Nano

Single-virus content mixing assay reveals cholesterol-enhanced influenza membrane fusion efficiency

(2021) Katherine N. Liu et al.   BIOPHYSICAL JOURNAL

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

(2021) Manuel J. Carrasco et al.   Communications Biology

Chemistry of Lipid Nanoparticles for RNA Delivery

(2021) Yulia Eygeris et al.   ACCOUNTS OF CHEMICAL RESEARCH

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

(2021) Prasath Paramasivam et al.   JOURNAL OF CELL BIOLOGY

Imaging small molecule-induced endosomal escape of siRNA

(2020) Hampus Du Rietz et al.   Nature Communications

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

(2020) Valentina Francia et al.   BIOCONJUGATE CHEMISTRY

Competitive multivalent coadsorption and desorption of biological nanoparticles on a supported lipid bilayer

(2020) Vladimir P. Zhdanov   CHEMICAL PHYSICS LETTERS

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

(2019) Isabelle M. S. Degors et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

PAMAM dendrimer - cell membrane interactions

(2018) Laura J. Fox et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

(2018) Samuel A. Smith et al.   BIOCONJUGATE CHEMISTRY

Biologically Complex Planar Cell Plasma Membranes Supported on Polyelectrolyte Cushions Enhance Transmembrane Protein Mobility and Retain Native Orientation

(2017) Han-Yuan Liu et al.   LANGMUIR

Detachment of Membrane Bound Virions by Competitive Ligand Binding Induced Receptor Depletion

(2017) Nagma Parveen et al.   LANGMUIR

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles

(2017) Laura I. Selby et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Disentangling Viral Membrane Fusion from Receptor Binding Using Synthetic DNA-Lipid Conjugates

(2016) Robert J. Rawle et al.   BIOPHYSICAL JOURNAL

Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid

(2016) Yuta Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion

(2016) Sung-Tae Yang et al.   Nature Communications

Preserved Transmembrane Protein Mobility in Polymer-Supported Lipid Bilayers Derived from Cell Membranes

(2015) Hudson Pace et al.   ANALYTICAL CHEMISTRY

Advances in studies of nanoparticle–biomembrane interactions

(2015) Xiao Cong He et al.   Nanomedicine

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Biomechanics and Thermodynamics of Nanoparticle Interactions with Plasma and Endosomal Membrane Lipids in Cellular Uptake and Endosomal Escape

(2014) Chiranjeevi Peetla et al.   LANGMUIR

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Detection of Membrane-Binding Proteins by Surface Plasmon Resonance with an All-Aqueous Amplification Scheme

(2012) Ying Liu et al.   ANALYTICAL CHEMISTRY

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effect of Gold Nanoparticle Aggregation on Cell Uptake and Toxicity

(2011) Alexandre Albanese et al.   ACS Nano

Substrate effects on interactions of lipid bilayer assemblies with bound nanoparticles

(2011) Matthew P. Goertz et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

A fast, single-vesicle fusion assay mimics physiological SNARE requirements

(2010) Erdem Karatekin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Transfer between Charged Supported Lipid Bilayers and Oppositely Charged Vesicles

(2009) Angelika Kunze et al.   LANGMUIR

A Method Improving the Accuracy of Fluorescence Recovery after Photobleaching Analysis

(2008) Peter Jönsson et al.   BIOPHYSICAL JOURNAL

Molecular assemblies and membrane domains in multivesicular endosome dynamics

(2008) Thomas Falguières et al.   EXPERIMENTAL CELL RESEARCH

Real-Time QCM-D Monitoring of Electrostatically Driven Lipid Transfer between Two Lipid Bilayer Membranes

(2008) Angelica Wikström et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Interaction of Nanoparticles with Lipid Membrane

(2008) Yuri Roiter et al.   NANO LETTERS

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA