Nanosac, a Noncationic and Soft Polyphenol Nanocapsule, Enables Systemic Delivery of siRNA to Solid Tumors

Givosiran: First Approval

(2020) Lesley J. Scott   DRUGS

Sugar-Nanocapsules Imprinted with Microbial Molecular Patterns for mRNA Vaccination

(2020) Sejin Son et al.   NANO LETTERS

The entry of nanoparticles into solid tumours

(2020) Shrey Sindhwani et al.   NATURE MATERIALS

Enzyme-Triggered Transcytosis of Dendrimer–Drug Conjugate for Deep Penetration into Pancreatic Tumors

(2020) Guowei Wang et al.   ACS Nano

Nanoparticle elasticity regulates phagocytosis and cancer cell uptake

(2020) Yue Hui et al.   Science Advances

The dose threshold for nanoparticle tumour delivery

(2020) Ben Ouyang et al.   NATURE MATERIALS

The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency

(2019) Qingle Liang et al.   Nature Biomedical Engineering

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

(2019) Isabelle M. S. Degors et al.   ACCOUNTS OF CHEMICAL RESEARCH

Role of Nanoparticle Mechanical Properties in Cancer Drug Delivery

(2019) Yue Hui et al.   ACS Nano

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing

(2019) Anouar Belkacemi et al.   Jove-Journal of Visualized Experiments

Flocculation of silica nanoparticles by natural, wood-based polyelectrolytes

(2019) Kinga Grenda et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting

(2018) Yue Hui et al.   ACS Nano

Surface modification of polymer nanoparticles with native albumin for enhancing drug delivery to solid tumors

(2018) Hyesun Hyun et al.   BIOMATERIALS

Potentiation of PD-L1 blockade with a potency-matched dual cytokine–antibody fusion protein leads to cancer eradication in BALB/c-derived tumors but not in other mouse strains

(2018) Roberto De Luca et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Modulating the rigidity of nanoparticles for tumor penetration

(2018) Hongzhang Deng et al.   CHEMICAL COMMUNICATIONS

Nanoparticle elasticity directs tumor uptake

(2018) Peng Guo et al.   Nature Communications

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

(2018) Ann L.B. Seynhaeve et al.   Jove-Journal of Visualized Experiments

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Synthetic materials at the forefront of gene delivery

(2018) Irene Lostalé-Seijo et al.   Nature Reviews Chemistry

Reversible flocculation of nanoparticles by a carbamate surfactant

(2018) Anna-Karin Hellström et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Intracellular Fate of Nanoparticles with Polydopamine Surface Engineering and a Novel Strategy for Exocytosis-Inhibiting, Lysosome Impairment-Based Cancer Therapy

(2017) Li Ding et al.   NANO LETTERS

Effect of Sodium Sulfite, Sodium Dodecyl Sulfate, and Urea on the Molecular Interactions and Properties of Whey Protein Isolate-Based Films

(2017) Markus Schmid et al.   Frontiers in Chemistry

Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines

(2016) Jinho Park et al.   ADVANCED DRUG DELIVERY REVIEWS

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

PEGylation of lipoplexes: The right balance between cytotoxicity and siRNA effectiveness

(2016) Anna Lechanteur et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery

(2016) Yu Matsumoto et al.   Nature Nanotechnology

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice

(2015) Huan Meng et al.   ACS Nano

Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis, and Targeting

(2015) Aaron C. Anselmo et al.   ACS Nano

Soft Discoidal Polymeric Nanoconstructs Resist Macrophage Uptake and Enhance Vascular Targeting in Tumors

(2015) Jaehong Key et al.   ACS Nano

Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK

(2015) Idit Sagiv-Barfi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of amino groups of mesoporous silica nanoparticles on CpG oligodexynucleotide delivery

(2015) Yi Xu et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs

(2014) Qihang Sun et al.   ADVANCED MATERIALS

Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

(2014) John C Castle et al.   BMC GENOMICS

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

(2014) James E. Dahlman et al.   Nature Nanotechnology

SPARC Expression Correlates with Tumor Response to Albumin-Bound Paclitaxel in Head and Neck Cancer Patients

(2014) Neil Desai et al.   Translational Oncology

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors

(2013) Hiroto Hatakeyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Preformed albumin corona, a protective coating for nanoparticles based drug delivery system

(2013) Qiang Peng et al.   BIOMATERIALS

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation

(2012) Lei Zhang et al.   ACS Nano

Morphology and Properties of Microcapsules with Different Core Releases

(2012) Olga Shchepelina et al.   CHEMISTRY OF MATERIALS

Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective

(2011) S.M. Moghimi et al.   Annual Review of Pharmacology and Toxicology

Flocculation performance of a cationic biopolymer derived from a cellulosic source in mild aqueous solution

(2011) Henrikki Liimatainen et al.   BIORESOURCE TECHNOLOGY

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers

(2011) Carlee E. Ashley et al.   NATURE MATERIALS

In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters

(2011) Gregory M Palmer et al.   Nature Protocols

Polymers in Small-Interfering RNA Delivery

(2011) Kaushik Singha et al.   Nucleic Acid Therapeutics

Delivery of siRNA Therapeutics: Barriers and Carriers

(2010) Jie Wang et al.   AAPS Journal

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

(2010) Arnold Hayer et al.   JOURNAL OF CELL BIOLOGY

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

(2009) Parag Aggarwal et al.   ADVANCED DRUG DELIVERY REVIEWS

A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation

(2009) X. Zheng et al.   BLOOD

Endocytosisviacaveolae: alternative pathway with distinct cellular compartments to avoid lysosomal degradation?

(2009) Anna L. Kiss et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

DiC14-amidine cationic liposomes stimulate myeloid dendritic cells through Toll-like receptor 4

(2008) Tetsuya Tanaka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle Biodistribution

(2008) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY