A Combined Ligand- and Structure-Based Virtual Screening To Identify Novel NaV1.2 Blockers: In Vitro Patch Clamp Validation and In Vivo Anticonvulsant Activity

Pharmacologically targeting transient receptor potential channels for seizures and epilepsy: Emerging preclinical evidence of druggability

(2023) Jianxiong Jiang et al.   PHARMACOLOGY & THERAPEUTICS

Structure-Based Virtual Screening Identifies Novobiocin, Montelukast, and Cinnarizine as TRPV1 Modulators with Anticonvulsant Activity In Vivo

(2022) Manuel A. Llanos et al.   Journal of Chemical Information and Modeling

iRaPCA and SOMoC: Development and Validation of Web Applications for New Approaches for the Clustering of Small Molecules

(2022) Denis N. Prada Gori et al.   Journal of Chemical Information and Modeling

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures

(2022) Samrat Thouta et al.   Frontiers in Cellular Neuroscience

Recent advances in computational studies on voltage‐gated sodium channels: Drug design and mechanism studies

(2022) Gaoang Wang et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Contribution of non-selective membrane channels and receptors in epilepsy

(2021) Claudia García-Rodríguez et al.   PHARMACOLOGY & THERAPEUTICS

The Pharmacoresistant Epilepsy: An Overview on Existant and New Emerging Therapies

(2021) Antonella Fattorusso et al.   Frontiers in Neurology

Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1

(2021) Manuel A. Llanos et al.   CHEMISTRY & BIODIVERSITY

D3R grand challenge 4: blind prediction of protein–ligand poses, affinity rankings, and relative binding free energies

(2020) Conor D. Parks et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Analysis of gene variants in the GASH/Sal model of epilepsy

(2020) Elena Díaz-Casado et al.   PLoS One

Parabens inhibit hNaV 1.2 channels

(2020) Andrea Enrique et al.   BIOMEDICINE & PHARMACOTHERAPY

Epilepsy-Related Voltage-Gated Sodium Channelopathies: A Review

(2020) Luis Felipe Santos Menezes et al.   Frontiers in Pharmacology

Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems

(2019) Maksim V. Storozhuk et al.   Biomed Research International

Inherited Cardiac Arrhythmias and Channelopathies

(2019) Jessica Kline et al.   MEDICAL CLINICS OF NORTH AMERICA

Exploiting cannabinoid and vanilloid mechanisms for epilepsy treatment

(2019) Laila Asth et al.   EPILEPSY & BEHAVIOR

Mordred: a molecular descriptor calculator

(2018) Hirotomo Moriwaki et al.   Journal of Cheminformatics

ChEMBL: towards direct deposition of bioassay data

(2018) David Mendez et al.   NUCLEIC ACIDS RESEARCH

The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal

(2017) Luis J. Muñoz et al.   EPILEPSY & BEHAVIOR

Pharmacological and neuroethological study of the acute and chronic effects of lamotrigine in the genetic audiogenic seizure hamster (GASH:Sal)

(2017) B. Barrera-Bailón et al.   EPILEPSY & BEHAVIOR

Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

(2017) Denis B. Tikhonov et al.   JOURNAL OF GENERAL PHYSIOLOGY

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Expanding the toolkit for membrane protein modeling in Rosetta

(2016) Julia Koehler Leman et al.   BIOINFORMATICS

Montelukast reduces seizures in pentylenetetrazol-kindled mice

(2016) J. Fleck et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Role of Sodium Channels in Epilepsy

(2016) David I. Kaplan et al.   Cold Spring Harbor Perspectives in Medicine

Fast, accurate, and reliable molecular docking with QuickVina 2

(2015) Amr Alhossary et al.   BIOINFORMATICS

Voltage gated sodium channels as drug discovery targets

(2015) Sharan K Bagal et al.   Channels

TRPV1 Channel: A Potential Drug Target for Treating Epilepsy

(2015) Mustafa Nazıroglu   Current Neuropharmacology

Recent progress in sodium channel modulators for pain

(2014) Sharan K. Bagal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cannabinoid 1 and Transient Receptor Potential Vanilloid 1 Receptors Discretely Modulate Evoked Glutamate Separately from Spontaneous Glutamate Transmission

(2014) J. A. Fawley et al.   JOURNAL OF NEUROSCIENCE

Properties of human brain sodium channel α-subunits expressed in HEK293 cells and their modulation by carbamazepine, phenytoin and lamotrigine

(2013) Xin Qiao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal)

(2013) B. Barrera-Bailón et al.   EPILEPSY & BEHAVIOR

Systems biology, complexity, and the impact on antiepileptic drug discovery

(2013) Doru Georg Margineanu   EPILEPSY & BEHAVIOR

Lessons Learned in Empirical Scoring with smina from the CSAR 2011 Benchmarking Exercise

(2013) David Ryan Koes et al.   Journal of Chemical Information and Modeling

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking

(2012) Michael M. Mysinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore

(2010) G. M. Lipkind et al.   MOLECULAR PHARMACOLOGY

Sodium channelopathies and pain

(2010) Angelika Lampert et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

From ion channels to complex networks: Magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy

(2008) Matt T. Bianchi et al.   MEDICAL HYPOTHESES