Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures

Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome

(2022) Keisuke Kaneko et al.   Cell Reports

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

(2022) JP Johnson et al.   eLife

Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells

(2021) Perry W.E. Spratt et al.   Cell Reports

The Effect of Anti-seizure Medications on the Propagation of Epileptic Activity: A Review

(2021) Mohamed Khateb et al.   Frontiers in Neurology

Phenotypic and genetic spectrum of SCN 8A ‐related disorders, treatment options, and outcomes

(2020) Elena Gardella et al.   EPILEPSIA

Feedforward inhibition ahead of ictal wavefronts is provided by both parvalbumin‐ and somatostatin‐expressing interneurons

(2019) R. Ryley Parrish et al.   JOURNAL OF PHYSIOLOGY-LONDON

The spectrum of intermediate SCN 8A ‐related epilepsy

(2019) Katrine M. Johannesen et al.   EPILEPSIA

Simultaneous profiling of activity patterns in multiple neuronal subclasses

(2018) R. Ryley Parrish et al.   JOURNAL OF NEUROSCIENCE METHODS

Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation

(2018) Michael Chang et al.   NEUROBIOLOGY OF DISEASE

Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons

(2018) Efrat Katz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABAergic Interneurons in Seizures: Investigating Causality With Optogenetics

(2018) Vincent Magloire et al.   NEUROSCIENTIST

Interneuronal Network Activity at the Onset of Seizure-Like Events in Entorhinal Cortex Slices

(2017) Laura Librizzi et al.   JOURNAL OF NEUROSCIENCE

Interneuron activity leads to initiation of low-voltage fast-onset seizures

(2015) Zahra Shiri et al.   ANNALS OF NEUROLOGY

Voltage-gated sodium channels

(2015) Kevin Kwong et al.   CURRENT OPINION IN PHARMACOLOGY

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

(2015) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex

(2015) Latefa Yekhlef et al.   JOURNAL OF NEUROPHYSIOLOGY

Parvalbumin-Positive Inhibitory Interneurons Oppose Propagation But Favor Generation of Focal Epileptiform Activity

(2015) M. Sessolo et al.   JOURNAL OF NEUROSCIENCE

The phenotypic spectrum of SCN8A encephalopathy

(2015) J. Larsen et al.   NEUROLOGY

Function of Inhibitory Micronetworks Is Spared by Na+ Channel-Acting Anticonvulsant Drugs

(2014) L. Pothmann et al.   JOURNAL OF NEUROSCIENCE

A supercritical density of Na+ channels ensures fast signaling in GABAergic interneuron axons

(2014) Hua Hu et al.   NATURE NEUROSCIENCE

Molecular identity of axonal sodium channels in human cortical pyramidal cells

(2014) Cuiping Tian et al.   Frontiers in Cellular Neuroscience

Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability

(2013) Janelle E. O'Brien et al.   Frontiers in Genetics

Prognostic, clinical and demographic features in SCN1A mutation-positive Dravet syndrome

(2012) A. Brunklaus et al.   BRAIN

Co-expression of NaVβ subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins

(2012) Min-Min Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Recent Advances in the Medicinal Chemistry of Sodium Channel Blockers and their Therapeutic Potential

(2012) Valentina Zuliani et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

SCN1A mutations in Dravet syndrome: Impact of interneuron dysfunction on neural networks and cognitive outcome

(2012) Alex C. Bender et al.   EPILEPSY & BEHAVIOR

Use-dependent block of the voltage-gated Na+channel by tetrodotoxin and saxitoxin: Effect of pore mutations that change ionic selectivity

(2012) Chien-Jung Huang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons

(2012) Yul Young Park et al.   JOURNAL OF NEUROPHYSIOLOGY

Fast spiking interneuron control of seizure propagation in a cortical slice model of focal epilepsy

(2012) Mario Cammarota et al.   JOURNAL OF PHYSIOLOGY-LONDON

Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility

(2012) Stacey B. Dutton et al.   NEUROBIOLOGY OF DISEASE

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

(2012) C. S. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in Na+ Conductance Density and Na+ Channel Functional Properties Between Dopamine and GABA Neurons of the Rat Substantia Nigra

(2010) Vincent Seutin et al.   JOURNAL OF NEUROPHYSIOLOGY

NaV1.1 channels and epilepsy

(2010) William A. Catterall et al.   JOURNAL OF PHYSIOLOGY-LONDON

SCN2A mutation associated with neonatal epilepsy, late-onset episodic ataxia, myoclonus, and pain

(2010) Y. Liao et al.   NEUROLOGY

Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation

(2009) Wenqin Hu et al.   NATURE NEUROSCIENCE

De novo mutations of voltage-gated sodium channel  II gene SCN2A in intractable epilepsies

(2009) I. Ogiwara et al.   NEUROLOGY

Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures

(2008) Sunita N. Misra et al.   EPILEPSIA