Acetylshikonin induces apoptosis through the endoplasmic reticulum stress‐activated PERK/eIF2α/CHOP axis in oesophageal squamous cell carcinoma

HDLs extract lipophilic drugs from cells

(2022) Adi Zheng et al.   JOURNAL OF CELL SCIENCE

Acetylshikonin induces autophagy‐dependent apoptosis through the key LKB1‐AMPK and PI3K/Akt‐regulated mTOR signalling pathways in HL‐60 cells

(2022) Meng‐Di Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Acetylshikonin, A Novel CYP2J2 Inhibitor, Induces Apoptosis in RCC Cells via FOXO3 Activation and ROS Elevation

(2022) Heui Min Lim et al.   Oxidative Medicine and Cellular Longevity

The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020

(2022) Eileen Morgan et al.   GASTROENTEROLOGY

Low-molecular-weight fucoidan bidirectionally regulates lipid uptake and cholesterol efflux through the p38 MAPK phosphorylation

(2022) Yu Sun et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibition of TRPA1 Ameliorates Periodontitis by Reducing Periodontal Ligament Cell Oxidative Stress and Apoptosis via PERK/eIF2α/ATF-4/CHOP Signal Pathway

(2022) Qian Liu et al.   Oxidative Medicine and Cellular Longevity

Acetylshikonin exerts anti-tumor effects on non-small cell lung cancer through dual inhibition of STAT3 and EGFR

(2022) Yemeng Tang et al.   PHYTOMEDICINE

The endoplasmic reticulum stress response in prostate cancer

(2022) Claire M. de la Calle et al.   Nature Reviews Urology

Changing trends in the disease burden of esophageal cancer in China from 1990 to 2017 and its predicted level in 25 years

(2021) Songbo Li et al.   Cancer Medicine

Immunotherapy for esophageal cancer

(2021) Saheli Sadanand   NATURE MEDICINE

Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation

(2021) Heui Min Lim et al.   Oxidative Medicine and Cellular Longevity

The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer

(2021) Zhixiu Xia et al.   World Journal of Surgical Oncology

Surfactin induces ER stress‐mediated apoptosis via IRE1‐ASK1‐JNK signaling in human osteosarcoma

(2021) Guo‐Shou Wang et al.   ENVIRONMENTAL TOXICOLOGY

Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

(2021) Qiang Sun et al.   PHYTOMEDICINE

Transcriptome analysis upon potassium usnate exposure reveals ATF3-induced apoptosis in human gastric and colon cancer cells

(2021) Kyung Hyun Yoo et al.   PHYTOMEDICINE

A natural anthraquinone derivative shikonin synergizes with AZD9291 against wtEGFR NSCLC cells through reactive oxygen species-mediated endoplasmic reticulum stress

(2020) Xiu Hu et al.   PHYTOMEDICINE

Homocysteine induces melanocytes apoptosis via PERK–eIF2α–CHOP pathway in vitiligo

(2020) Jiaxi Chen et al.   CLINICAL SCIENCE

LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis

(2020) Xiao-xuan Yu et al.   ACTA PHARMACOLOGICA SINICA

Esophageal Cancer Surgery

(2020) Ioana Baiu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells

(2020) Jian‐Ling Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

(2019) Hai Hu et al.   Frontiers in Immunology

Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance

(2019) Lorenza Sisinni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shikonin derivatives for cancer prevention and therapy

(2019) Joelle C. Boulos et al.   CANCER LETTERS

Emerging Multimodality Approaches to Treat Localized Esophageal Cancer

(2019) Ronan J. Kelly   Journal of the National Comprehensive Cancer Network

Pharmacological properties and derivatives of shikonin—A review in recent years

(2019) Chuanjie Guo et al.   PHARMACOLOGICAL RESEARCH

Lobaplatin promotes 125I-induced apoptosis and inhibition of proliferation in hepatocellular carcinoma by upregulating PERK-eIF2α-ATF4-CHOP pathway

(2019) Dong Li et al.   Cell Death & Disease

Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation

(2019) Ming Hong et al.   Cells

Acetylshikonin induces apoptosis of human leukemia cell line K562 by inducing S phase cell cycle arrest, modulating ROS accumulation, depleting Bcr-Abl and blocking NF-κB signaling

(2019) Gangping Hao et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer

(2018) Xi Cheng et al.   CANCER LETTERS

The unfolded protein response as a target for anticancer therapeutics

(2018) Mengxiong Wang et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

CaMKⅡ mediates cadmium induced apoptosis in rat primary osteoblasts through MAPK activation and endoplasmic reticulum stress

(2018) Wei Liu et al.   TOXICOLOGY

Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review

(2018) Changmin Kim et al.   Nutrients

Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells

(2017) See-Hyoung Park et al.   PHYTOMEDICINE

Endoplasmic reticulum stress could induce autophagy and apoptosis and enhance chemotherapy sensitivity in human esophageal cancer EC9706 cells by mediating PI3K/Akt/mTOR signaling pathway

(2017) Fang Zhou et al.   TUMOR BIOLOGY

YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway

(2017) Zekun Chen et al.   Theranostics

Acetylshikonin inhibits growth of oral squamous cell carcinoma by inducing apoptosis

(2016) Da Jeong Kim et al.   ARCHIVES OF ORAL BIOLOGY

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity

(2015) Seok-Cheol Cho et al.   Biomolecules & Therapeutics

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Induction of DNA damage and ATF3 by retigeric acid B, a novel topoisomerase II inhibitor, promotes apoptosis in prostate cancer cells

(2013) Yongqing Liu et al.   CANCER LETTERS

Targeting ER stress induced apoptosis and inflammation in cancer

(2010) Tom Verfaillie et al.   CANCER LETTERS

An Efficient Method for Extraction, Separation and Purification of Naphthoquinone Pigments from Lithospermum erythrorhizon Sieb. et Zucc. by SFE and HSCCC

(2009) Lei Feng et al.   CHROMATOGRAPHIA

Inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 in vitro and in vivo

(2009) Yun Zeng et al.   WORLD JOURNAL OF GASTROENTEROLOGY