Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation

Colorectal cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

p27 as a transcriptional regulator: New roles in development and cancer

(2020) Seyedeh Fatemeh Razavipour et al.   CANCER RESEARCH

Induction of cell cycle arrest and apoptosis by tomentosin in hepatocellular carcinoma HepG2 and Huh7 cells

(2020) SH Yu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

6, 8‐Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53

(2020) Yong Jun Choi et al.   ENVIRONMENTAL TOXICOLOGY

6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2

(2020) Chang Min Lee et al.   Oxidative Medicine and Cellular Longevity

Colorectal Cancer and Nutrition

(2019) Kannan Thanikachalam et al.   Nutrients

Tomentosin Displays Anti-Carcinogenic Effect in Human Osteosarcoma MG-63 Cells via the Induction of Intracellular Reactive Oxygen Species

(2019) Chang Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shikonin derivatives for cancer prevention and therapy

(2019) Joelle C. Boulos et al.   CANCER LETTERS

Early colorectal cancer: diagnosis, treatment and survivorship care

(2019) Gabriella Buccafusca et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma

(2019) Arthur W. Currier et al.   Scientific Reports

Dietary phytochemicals with anti-oxidant and pro-oxidant activities: A double-edged sword in relation to adjuvant chemotherapy and radiotherapy?

(2019) Wasundara Fernando et al.   CANCER LETTERS

Interleukin4Rα (IL4Rα) and IL13Rα1 Are Associated with the Progress of Renal Cell Carcinoma through Janus Kinase 2 (JAK2)/Forkhead Box O3 (FOXO3) Pathways

(2019) Mi-Ae Kang et al.   Cancers

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

(2019) Mingyang Song et al.   GASTROENTEROLOGY

Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation

(2019) Ming Hong et al.   Cells

Cytoplasmic p27 is a novel prognostic biomarker and oncogenic protein for nasopharyngeal carcinoma

(2019) Yaoshu Teng et al.   Artificial Cells Nanomedicine and Biotechnology

Indole-3-carbinol induces apoptosis in human hepatocellular carcinoma Huh-7 cells

(2018) Chang Min Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

(2018) Shang Yao et al.   SEMINARS IN CANCER BIOLOGY

Re-evaluating the role of FOXOs in cancer

(2018) M. Hornsveld et al.   SEMINARS IN CANCER BIOLOGY

Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway

(2018) See‑Hyoung Park et al.   Oncology Letters

Phytochemicals in anticancer drug development

(2018) Rohit Dutt et al.   Anti-Cancer Agents in Medicinal Chemistry

FOXO Signaling Pathways as Therapeutic Targets in Cancer

(2017) Mohd Farhan et al.   International Journal of Biological Sciences

Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells

(2017) See-Hyoung Park et al.   PHYTOMEDICINE

Acetylshikonin inhibits growth of oral squamous cell carcinoma by inducing apoptosis

(2016) Da Jeong Kim et al.   ARCHIVES OF ORAL BIOLOGY

Genistein induces apoptosis by down-regulating thioredoxin-1 in human hepatocellular carcinoma SNU-449 cells

(2016) Taylor Roh et al.   FOOD AND CHEMICAL TOXICOLOGY

Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity

(2015) Seok-Cheol Cho et al.   Biomolecules & Therapeutics

FOXO3: A Major Gene for Human Longevity - A Mini-Review

(2015) Brian J. Morris et al.   GERONTOLOGY

FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis

(2014) Jiao Wang et al.   APOPTOSIS

Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53

(2014) SEE-HYOUN G PARK et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure

(2013) Irina Tikhanovich et al.   HEPATOLOGY

Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activation

(2013) Sun-Uk Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3

(2012) J. Hagenbuchner et al.   JOURNAL OF CELL SCIENCE

The expression and prognosis of FOXO3a and Skp2 in human ovarian cancer

(2012) Mudan Lu et al.   MEDICAL ONCOLOGY

Inhibition of Mitochondrial CytochromecRelease and Suppression of Caspases by Gamma-Tocotrienol Prevent Apoptosis and Delay Aging in Stress-Induced Premature Senescence of Skin Fibroblasts

(2012) Suzana Makpol et al.   Oxidative Medicine and Cellular Longevity

FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

(2012) Young Min Chung et al.   Nature Communications

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

(2011) F Wang et al.   ONCOGENE

Metastatic Colorectal Cancer: From Improved Survival to Potential Cure

(2010) David J. Gallagher et al.   ONCOLOGY

Inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 in vitro and in vivo

(2009) Yun Zeng et al.   WORLD JOURNAL OF GASTROENTEROLOGY

In vitro and in vivo antitumor effects of acetylshikonin isolated from Arnebia euchroma (Royle) Johnst (Ruanzicao) cell suspension cultures

(2009) Wenbi Xiong et al.   Chinese Medicine

Shiunko and Acetylshikonin Promote Reepithelialization, Angiogenesis, and Granulation Tissue Formation in Wounded Skin

(2008) Pao-Ju Lu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Shikonin, Acetylshikonin, and Isobutyroylshikonin Inhibit VEGF-induced Angiogenesis and Suppress Tumor Growth in Lewis Lung Carcinoma-bearing Mice

(2008) Hyo-Jung LEE et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN