Reconstituted dry powder formulations of ZnO-adjuvanted ovalbumin induce equivalent antigen specific antibodies but lower T cell responses than ovalbumin adjuvanted with Alhydrogel® or cationic adjuvant formulation 01 (CAF®01)

Pulmonary Administration of the Liposome-Based Adjuvant CAF01: Effect of Surface Charge on Mucosal Adjuvant Function

(2022) Olivia Amanda Oest Müllertz et al.   Molecular Pharmaceutics

Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice

(2021) Katharina Wørzner et al.   EBioMedicine

Inhaled RNA Therapeutics for Obstructive Airway Diseases: Recent Advances and Future Prospects

(2021) You Xu et al.   Pharmaceutics

Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

(2021) Joana T. Pinto et al.   DRYING TECHNOLOGY

Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials

(2021) Eva Jablonská et al.   Scientific Reports

Why and How Vaccines Work

(2020) Akiko Iwasaki et al.   CELL

Vaccine Adjuvants Differentially Affect Kinetics of Antibody and Germinal Center Responses

(2020) Gabriel Kristian Pedersen et al.   Frontiers in Immunology

Effect of Particle Deposition Density of Dry Powders on the Results Produced by an In Vitro Test System Simulating Dissolution- and Absorption Rates in the Lungs

(2019) Maria Malmlöf et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial

(2019) Sonya Abraham et al.   LANCET INFECTIOUS DISEASES

Optimized Protocol for the Detection of Multifunctional Epitope-Specific CD4+ T Cells Combining MHC-II Tetramer and Intracellular Cytokine Staining Technologies

(2019) Gabiria Pastore et al.   Frontiers in Immunology

Investigation of Lung Pharmacokinetic of the Novel PDE4 Inhibitor CHF6001 in Preclinical Models: Evaluation of the PreciseInhale Technology

(2018) Alessandro Fioni et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines

(2018) Giuseppe Del Giudice et al.   SEMINARS IN IMMUNOLOGY

Immunological and physical evaluation of the multistage tuberculosis subunit vaccine candidate H56/CAF01 formulated as a spray-dried powder

(2018) Aneesh Thakur et al.   VACCINE

Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

(2018) Aneesh Thakur et al.   Frontiers in Immunology

Mesoporous ZnO nanocapsules for the induction of enhanced antigen-specific immunological responses

(2017) Sumbul Afroz et al.   Nanoscale

Hollow ZnO Nanospheres Enhance Anticancer Immunity by Promoting CD4+ and CD8+ T Cell Populations In Vivo

(2017) Xiupeng Wang et al.   Small

Role of Metallic Nanoparticles in Vaccinology: Implications for Infectious Disease Vaccine Development

(2017) Lázaro Moreira Marques Neto et al.   Frontiers in Immunology

Germinal Center B Cell and T Follicular Helper Cell Responses to Viral Vector and Protein-in-Adjuvant Vaccines

(2016) Chuan Wang et al.   JOURNAL OF IMMUNOLOGY

Intravaginal Zinc Oxide Tetrapod Nanoparticles as Novel Immunoprotective Agents against Genital Herpes

(2016) Thessicar E. Antoine et al.   JOURNAL OF IMMUNOLOGY

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses

(2016) D Christensen et al.   Mucosal Immunology

Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung

(2016) J S Woodworth et al.   Mucosal Immunology

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

(2016) Niels Peter H. Knudsen et al.   Scientific Reports

Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants

(2016) Thorunn A. Olafsdottir et al.   Scientific Reports

ZnO nanoparticles induced adjuvant effect via toll-like receptors and Src signaling in Balb/c mice

(2014) Ruchi Roy et al.   TOXICOLOGY LETTERS

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

(2014) Jaap T. van Dissel et al.   VACCINE

Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau

(2013) Victor Raúl Gómez Román et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Biomedical Applications of Zinc Oxide Nanomaterials

(2013) Y. Zhang et al.   CURRENT MOLECULAR MEDICINE

Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb/c mice

(2013) Ruchi Roy et al.   INTERNATIONAL IMMUNOLOGY

Spray dried mannitol carrier particles with tailored surface properties – The influence of carrier surface roughness and shape

(2012) E.M. Littringer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Vaccine-Induced Th17 Cells Are Maintained Long-Term Postvaccination as a Distinct and Phenotypically Stable Memory Subset

(2012) Thomas Lindenstrøm et al.   INFECTION AND IMMUNITY

Dry Powder Inhalation Exposures of the Endotracheally Intubated Rat Lung, Ex Vivo and In Vivo: The Pulmonary Pharmacokinetics of Fluticasone Furoate

(2012) Ewa Selg et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

The Interplay of Lung Surfactant Proteins and Lipids Assimilates the Macrophage Clearance of Nanoparticles

(2012) Christian A. Ruge et al.   PLoS One

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA

(2011) Ditte Krohn Jensen et al.   JOURNAL OF CONTROLLED RELEASE

New developments in dry powder pulmonary vaccine delivery

(2011) Tomás Sou et al.   TRENDS IN BIOTECHNOLOGY

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

T cells and follicular dendritic cells in germinal center B-cell formation and selection

(2010) Carola G. Vinuesa et al.   IMMUNOLOGICAL REVIEWS

T-helper 1 and T-helper 2 adjuvants induce distinct differences in the magnitude, quality and kinetics of the early inflammatory response at the site of injection

(2009) Karen Smith Korsholm et al.   IMMUNOLOGY

Adjuvant effect of zinc oxide on Th2 but not Th1 immune responses in mice

(2009) Misa Matsumura et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY