Vaccine Adjuvants Differentially Affect Kinetics of Antibody and Germinal Center Responses

Engineered immunogen binding to alum adjuvant enhances humoral immunity

(2020) Tyson J. Moyer et al.   NATURE MEDICINE

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

(2019) Kimberly M. Cirelli et al.   CELL

Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination

(2019) Archana V. Boopathy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial

(2019) Sonya Abraham et al.   LANCET INFECTIOUS DISEASES

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines

(2018) Giuseppe Del Giudice et al.   SEMINARS IN IMMUNOLOGY

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want

(2018) Harm HogenEsch et al.   npj Vaccines

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

(2017) Jonatan Ersching et al.   IMMUNITY

Antigen Acquisition Enables Newly Arriving B Cells To Enter Ongoing Immunization-Induced Germinal Centers

(2017) Jackson S. Turner et al.   JOURNAL OF IMMUNOLOGY

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

(2017) Frank Liang et al.   Science Translational Medicine

Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis

(2017) Wook-Bin Lee et al.   Scientific Reports

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

(2016) Hok Hei Tam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen Presentation to B Cells

(2016) Balthasar A. Heesters et al.   TRENDS IN IMMUNOLOGY

Modulation of Primary Immune Response by Different Vaccine Adjuvants

(2016) Annalisa Ciabattini et al.   Frontiers in Immunology

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

(2016) Niels Peter H. Knudsen et al.   Scientific Reports

Oil-in-Water Emulsion MF59 Increases Germinal Center B Cell Differentiation and Persistence in Response to Vaccination

(2015) Giuseppe Lofano et al.   JOURNAL OF IMMUNOLOGY

Protection AgainstChlamydia trachomatisInfection and Upper Genital Tract Pathological Changes by Vaccine-Promoted Neutralizing Antibodies Directed to the VD4 of the Major Outer Membrane Protein

(2015) Anja W. Olsen et al.   JOURNAL OF INFECTIOUS DISEASES

First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

(2015) Angelique Kany Kany Luabeya et al.   VACCINE

Immunogenicity of reduced dose priming schedules of serogroup C meningococcal conjugate vaccine followed by booster at 12 months in infants: open label randomised controlled trial

(2015) D. Pace et al.   BMJ-British Medical Journal

Immunogenicity of reduced dose priming schedules of serogroup C meningococcal conjugate vaccine followed by booster at 12 months in infants: open label randomised controlled trial

(2015) D. Pace et al.   BMJ-British Medical Journal

Elucidating the mechanisms of protein antigen adsorption to the CAF/NAF liposomal vaccine adjuvant systems: Effect of charge, fluidity and antigen-to-lipid ratio

(2014) Mette Hamborg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Immunomodulatory properties of the vaccine adjuvant alum

(2014) Ewa Oleszycka et al.   CURRENT OPINION IN IMMUNOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Kinetics of the inflammatory response following intramuscular injection of aluminum adjuvant

(2013) Fangjia Lu et al.   VACCINE

Mechanism of Immunopotentiation and Safety of Aluminum Adjuvants

(2013) Harm HogenEsch   Frontiers in Immunology

Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype

(2012) Stacey L. Demento et al.   BIOMATERIALS

Dendritic cells sequester antigenic epitopes for prolonged periods in the absence of antigen-encoding genetic information

(2012) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of action of MF59 – An innately attractive adjuvant formulation

(2012) D.T. O’Hagan et al.   VACCINE

Antigen depot is not required for alum adjuvanticity

(2011) Sharon Hutchison et al.   FASEB JOURNAL

MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines

(2011) S. Khurana et al.   Science Translational Medicine

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

(2011) Samuele Calabro et al.   VACCINE

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity

(2011) Sandra Morel et al.   VACCINE

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

Comparison of the Depot Effect and Immunogenicity of Liposomes Based on Dimethyldioctadecylammonium (DDA), 3β-[N-(N′,N′-Dimethylaminoethane)carbomyl] Cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium Propane (DOTAP): Prolonged Liposome Retention Mediates Stronger Th1 Responses

(2010) Malou Henriksen-Lacey et al.   MOLECULAR PHARMACEUTICS

Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response

(2010) Stephanie M. Noe et al.   VACCINE

Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen

(2009) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation

(2009) Tri Giang Phan et al.   NATURE IMMUNOLOGY