Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

Imaging activated T cells predicts response to cancer vaccines

(2018) Israt S. Alam et al.   JOURNAL OF CLINICAL INVESTIGATION

New Tuberculosis Vaccine Strategies: Taking Aim at Un-Natural Immunity

(2018) Mangalakumari Jeyanathan et al.   TRENDS IN IMMUNOLOGY

Immunological and physical evaluation of the multistage tuberculosis subunit vaccine candidate H56/CAF01 formulated as a spray-dried powder

(2018) Aneesh Thakur et al.   VACCINE

High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis

(2018) Rolf Billeskov et al.   Frontiers in Immunology

Next-Generation Vaccines Based on Bacille Calmette–Guérin

(2018) Natalie E. Nieuwenhuizen et al.   Frontiers in Immunology

T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties

(2018) Thomas Lindenstrøm et al.   EBioMedicine

Adjuvants Based on Synthetic Mycobacterial Cord Factor Analogues: Biophysical Properties of Neat Glycolipids and Nanoself-Assemblies with DDA

(2017) Rie S. Kallerup et al.   MOLECULAR PHARMACEUTICS

Antibodies to Mycobacterium tuberculosis

(2017) Arturo Casadevall   NEW ENGLAND JOURNAL OF MEDICINE

Latently and uninfected healthcare workers exposed to TB make protective antibodies againstMycobacterium tuberculosis

(2017) Hao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced protection against FMDV in cattle after prime- boost vaccination based on mucosal and inactivated FMD vaccine

(2017) Manar E. Khalifa et al.   VETERINARY MICROBIOLOGY

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine

(2017) Rafael Prados-Rosales et al.   PLoS Pathogens

Intranasal Vaccination with Mannosylated Chitosan Formulated DNA Vaccine Enables Robust IgA and Cellular Response Induction in the Lungs of Mice and Improves Protection against Pulmonary Mycobacterial Challenge

(2017) Manli Wu et al.   Frontiers in Cellular and Infection Microbiology

Simultaneous Subcutaneous and Intranasal Administration of a CAF01-Adjuvanted Chlamydia Vaccine Elicits Elevated IgA and Protective Th1/Th17 Responses in the Genital Tract

(2017) Jeanette Erbo Wern   Frontiers in Immunology

Lactobacillus plantarum producing a Chlamydia trachomatis antigen induces a specific IgA response after mucosal booster immunization

(2017) Katarzyna Kuczkowska et al.   PLoS One

A Functional Role for Antibodies in Tuberculosis

(2016) Lenette L. Lu et al.   CELL

Radionuclide imaging of liposomal drug delivery

(2016) Tessa van der Geest et al.   Expert Opinion on Drug Delivery

Effects of B Cell Depletion on Early Mycobacterium tuberculosis Infection in Cynomolgus Macaques

(2016) Jiayao Phuah et al.   INFECTION AND IMMUNITY

Specific niches for lung-resident memory CD8 + T cells at the site of tissue regeneration enable CD69-independent maintenance

(2016) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses

(2016) D Christensen et al.   Mucosal Immunology

Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung

(2016) J S Woodworth et al.   Mucosal Immunology

Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations

(2016) S. Sharpe et al.   TUBERCULOSIS

Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis

(2016) Carolina Perdomo et al.   mBio

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

(2016) Kristin L. Griffiths et al.   Nature Communications

Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis

(2016) Rolf Billeskov et al.   PLoS One

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

(2016) Niels Peter H. Knudsen et al.   Scientific Reports

TB vaccines; promoting rapid and durable protection in the lung

(2015) Peter Andersen et al.   CURRENT OPINION IN IMMUNOLOGY

Influence of trehalose 6,6′-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes

(2015) Rie Selchau Kallerup et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Tissue instruction for migration and retention of TRM cells

(2015) Norifumi Iijima et al.   TRENDS IN IMMUNOLOGY

First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

(2015) Angelique Kany Kany Luabeya et al.   VACCINE

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

(2015) Deepak Kaushal et al.   Nature Communications

Intramuscular Priming and Intranasal Boosting Induce Strong Genital Immunity Through Secretory IgA in Minipigs Infected with Chlamydia trachomatis

(2015) Emma Lorenzen et al.   Frontiers in Immunology

Characterization of the Antigen-Specific CD4+ T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes

(2015) Annalisa Ciabattini et al.   Frontiers in Immunology

AdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human Primates

(2015) Mangalakumari Jeyanathan et al.   PLoS One

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

Cutting Edge: Control of Mycobacterium tuberculosis Infection by a Subset of Lung Parenchyma-Homing CD4 T Cells

(2014) S. Sakai et al.   JOURNAL OF IMMUNOLOGY

Intravascular staining for discrimination of vascular and tissue leukocytes

(2014) Kristin G Anderson et al.   Nature Protocols

Tuberculosis vaccines – rethinking the current paradigm

(2014) Peter Andersen et al.   TRENDS IN IMMUNOLOGY

Intratracheal Instillation Methods and the Distribution of Administered Material in the Lung of the Rat

(2014) Yasuko Hasegawa-Baba et al.   Journal of Toxicologic Pathology

Mycobacterial Membrane Vesicles Administered Systemically in Mice Induce a Protective Immune Response to Surface Compartments of Mycobacterium tuberculosis

(2014) R. Prados-Rosales et al.   mBio

T Cell–Mediated Host Immune Defenses in the Lung

(2013) Kong Chen et al.   Annual Review of Immunology

Antibody-Mediated Immunity against Tuberculosis: Implications for Vaccine Development

(2013) Jacqueline M. Achkar et al.   Cell Host & Microbe

Control of Chronic Mycobacterium tuberculosis Infection by CD4 KLRG1- IL-2-Secreting Central Memory Cells

(2013) T. Lindenstrom et al.   JOURNAL OF IMMUNOLOGY

The Physical Stability of the Recombinant Tuberculosis Fusion Antigens H1 and H56

(2013) Mette Hamborg et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Investigations of TB vaccine-induced mucosal protection in mice

(2013) Azra Blazevic et al.   MICROBES AND INFECTION

Enhanced protection against pulmonary mycobacterial challenge by chitosan-formulated polyepitope gene vaccine is associated with increased pulmonary secretory IgA and gamma-interferon+T cell responses

(2013) Wenqing Ai et al.   MICROBIOLOGY AND IMMUNOLOGY

Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells

(2013) M Jeyanathan et al.   Mucosal Immunology

Harnessing local and systemic immunity for vaccines against tuberculosis

(2013) P C L Beverley et al.   Mucosal Immunology

The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling

(2013) Christiane Desel et al.   PLoS One

Vaccines against mucosal infections

(2012) Jan Holmgren et al.   CURRENT OPINION IN IMMUNOLOGY

Vaccine-Induced Th17 Cells Are Maintained Long-Term Postvaccination as a Distinct and Phenotypically Stable Memory Subset

(2012) Thomas Lindenstrøm et al.   INFECTION AND IMMUNITY

A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog

(2012) Dennis Christensen et al.   JOURNAL OF CONTROLLED RELEASE

Synchronization of Dendritic Cell Activation and Antigen Exposure Is Required for the Induction of Th1/Th17 Responses

(2012) A. T. Kamath et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of delayed anti-tuberculosis protection in the lung of parenteral BCG-vaccinated hosts: A critical role of airway luminal T cells

(2012) C N Horvath et al.   Mucosal Immunology

Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity

(2012) M Jeyanathan et al.   Mucosal Immunology

Protein Antigen Adsorption to the DDA/TDB Liposomal Adjuvant: Effect on Protein Structure, Stability, and Liposome Physicochemical Characteristics

(2012) Mette Hamborg et al.   PHARMACEUTICAL RESEARCH

Tuberculosis vaccine development: strength lies in tenacity

(2012) Stefan H.E. Kaufmann   TRENDS IN IMMUNOLOGY

BCG: Myths, realities, and the need for alternative vaccine strategies

(2012) Helen McShane et al.   TUBERCULOSIS

Immune markers and correlates of protection for vaccine induced immune responses

(2012) Aneesh Thakur et al.   VACCINE

The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection

(2011) Philana Ling Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA Are Undetectable

(2011) S. C. De Rosa et al.   JOURNAL OF IMMUNOLOGY

A Novel Human IgA Monoclonal Antibody Protects against Tuberculosis

(2011) S. Balu et al.   JOURNAL OF IMMUNOLOGY

Initiation and regulation of T-cell responses in tuberculosis

(2011) K B Urdahl et al.   Mucosal Immunology

A multistage tuberculosis vaccine that confers efficient protection before and after exposure

(2011) Claus Aagaard et al.   NATURE MEDICINE

Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations

(2010) A. D. Cristillo et al.   JOURNAL OF GENERAL VIROLOGY

Pixel-based subsets for rapid multi-pinhole SPECT reconstruction

(2010) Woutjan Branderhorst et al.   PHYSICS IN MEDICINE AND BIOLOGY

Genetic immunization in the lung induces potent local and systemic immune responses

(2010) K. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Mediated Immune Responses in Tuberculosis

(2009) Andrea M. Cooper   Annual Review of Immunology

How B cells shape the immune response againstMycobacterium tuberculosis

(2009) Paul J. Maglione et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen

(2009) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin

(2009) David J. M. Lewis et al.   PLoS One

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY

Cationic Liposomes Formulated with Synthetic Mycobacterial Cordfactor (CAF01): A Versatile Adjuvant for Vaccines with Different Immunological Requirements

(2008) Else Marie Agger et al.   PLoS One

Mucosal immunization with recombinant heparin-binding haemagglutinin adhesin suppresses extrapulmonary dissemination of Mycobacterium bovis bacillus Calmette-Guérin (BCG) in infected mice

(2008) Hideyasu Kohama et al.   VACCINE