Vaccine-Induced Th17 Cells Are Maintained Long-Term Postvaccination as a Distinct and Phenotypically Stable Memory Subset

Both Th1 and Th17 Are Immunopathogenic but Differ in Other Key Biological Activities

(2014) C. A. Cox et al.   JOURNAL OF IMMUNOLOGY

Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response

(2014) T. J. Scriba et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: An IL-17F-CreEYFP Reporter Mouse Allows Fate Mapping of Th17 Cells

(2014) A. L. Croxford et al.   JOURNAL OF IMMUNOLOGY

Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells

(2011) S. Steinfelder et al.   BLOOD

Th17 Cells Mediate Clade-Specific, Serotype-Independent Mucosal Immunity

(2011) Kong Chen et al.   IMMUNITY

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

A multistage tuberculosis vaccine that confers efficient protection before and after exposure

(2011) Claus Aagaard et al.   NATURE MEDICINE

Role of IL-17A on Resolution of Pulmonary C. neoformans Infection

(2011) Karen L. Wozniak et al.   PLoS One

ESAT-6- and CFP-10-Specific Th1, Th22 and Th17 Cells in Tuberculous Pleurisy May Contribute to the Local Immune Response Against Mycobacterium Tuberculosis Infection

(2011) D. Qiao et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Human TH17 Cells Are Long-Lived Effector Memory Cells

(2011) I. Kryczek et al.   Science Translational Medicine

Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection

(2011) Jaap T. van Dissel et al.   VACCINE

Robust Antigen Specific Th17 T Cell Response to Group A Streptococcus Is Dependent on IL-6 and Intranasal Route of Infection

(2011) Thamotharampillai Dileepan et al.   PLoS Pathogens

Genetic proof for the transient nature of the Th17 phenotype

(2010) Florian C. Kurschus et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells

(2010) Maria H. Lexberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

(2010) Ryuta Mukasa et al.   IMMUNITY

Mycobacterium bovis BCG-Specific Th17 Cells Confer Partial Protection against Mycobacterium tuberculosis Infection in the Absence of Gamma Interferon

(2010) T. M. Wozniak et al.   INFECTION AND IMMUNITY

Chlamydia muridarum T-Cell Antigens Formulated with the Adjuvant DDA/TDB Induce Immunity against Infection That Correlates with a High Frequency of Gamma Interferon (IFN- )/Tumor Necrosis Factor Alpha and IFN- /Interleukin-17 Double-Positive CD4+ T Cells

(2010) H. Yu et al.   INFECTION AND IMMUNITY

Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection withMycobacterium tuberculosis

(2010) Andrea Cruz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCL20 and  -Defensin-2 Induce Arrest of Human Th17 Cells on Inflamed Endothelium In Vitro under Flow Conditions

(2010) S. Ghannam et al.   JOURNAL OF IMMUNOLOGY

Th17 Cells Are the Dominant T Cell Subtype Primed by Shigella flexneri Mediating Protective Immunity

(2010) Gernot Sellge et al.   JOURNAL OF IMMUNOLOGY

IL-17 Contributes to Cell-Mediated Defense against Pulmonary Yersinia pestis Infection

(2010) J.-S. Lin et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung

(2010) Y. Okamoto Yoshida et al.   JOURNAL OF IMMUNOLOGY

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

(2010) M. Mehling et al.   NEUROLOGY

Protection against Chlamydia Promoted by a Subunit Vaccine (CTH1) Compared with a Primary Intranasal Infection in a Mouse Genital Challenge Model

(2010) Anja Weinreich Olsen et al.   PLoS One

Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Helena S. Domingues et al.   PLoS One

Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax

(2010) S. K. Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers

(2010) Jaap T. van Dissel et al.   VACCINE

Reduced Th17 Response in Patients with Tuberculosis Correlates with IL-6R Expression on CD4+T Cells

(2009) Xinchun Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

(2009) Gang Wei et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation

(2009) Kerstin Werninghaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: In Vitro Generated Th17 Cells Maintain Their Cytokine Expression Program in Normal but Not Lymphopenic Hosts

(2009) R. Nurieva et al.   JOURNAL OF IMMUNOLOGY

Tuberculosis Subunit Vaccination Provides Long-Term Protective Immunity Characterized by Multifunctional CD4 Memory T Cells

(2009) T. Lindenstrom et al.   JOURNAL OF IMMUNOLOGY

Synergism between tumor necrosis factor alpha and interleukin-17 to induce IL-23 p19 expression in fibroblast-like synoviocytes

(2009) Michael Goldberg et al.   MOLECULAR IMMUNOLOGY

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells

(2009) Marion Pepper et al.   NATURE IMMUNOLOGY

CD4 and CD8 T Cell Responses to the M. tuberculosis Ag85B-TB10.4 Promoted by Adjuvanted Subunit, Adenovector or Heterologous Prime Boost Vaccination

(2009) Tara Elvang et al.   PLoS One

Immunological Memory Transferred with CD4 T Cells Specific for Tuberculosis Antigens Ag85B-TB10.4: Persisting Antigen Enhances Protection

(2009) Darragh Duffy et al.   PLoS One

Th memory for interleukin-17 expression is stablein vivo

(2008) Maria H. Lexberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

(2008) Shean J Aujla et al.   NATURE MEDICINE

Cationic Liposomes Formulated with Synthetic Mycobacterial Cordfactor (CAF01): A Versatile Adjuvant for Vaccines with Different Immunological Requirements

(2008) Else Marie Agger et al.   PLoS One