Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression

Fucoidan, a brown seaweed polysaccharide in nanodrug delivery

(2023) Archana George et al.   Drug Delivery and Translational Research

A probiotic supplement boosts response to cancer immunotherapy

(2022) Lisa Derosa et al.   NATURE MEDICINE

Melatonin has an inhibitory effect on MCF‐7 and MDA‐MB‐231 human breast cancer cell lines by inducing autophagy and apoptosis

(2022) Gözde Özge Önder et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Fucoidan Protects against Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Preventing Mitochondrial Function Injury

(2022) Yuting Ji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Triple negative breast cancer: Pitfalls and progress

(2022) Paola Zagami et al.   npj Breast Cancer

Biochemical characterization and anti-cancer activity of tangential flow filtration system assisted purification of fucoglucan from Laminaria japonica

(2022) Tung-Yi Lin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and oxidative stress

(2021) Saeed Mehrzadi et al.   Cancer Cell International

Melatonin inhibits triple-negative breast cancer progression through the Lnc049808-FUNDC1 pathway

(2021) Anli Yang et al.   Cell Death & Disease

Nanomedicine for increasing the oral bioavailability of cancer treatments

(2021) Alessandro Parodi et al.   JOURNAL OF NANOBIOTECHNOLOGY

Fucoidan-Based Nanoparticles with Inherently Therapeutic Efficacy for Cancer Treatment

(2021) Chih-Sheng Chiang et al.   Pharmaceutics

Molecular mediators of breast cancer metastasis

(2021) Ragini Yeeravalli et al.   Hematology/ Oncology and Stem Cell Therapy

Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies

(2020) Shichao Ding et al.   Materials Today

The role of melatonin on miRNAs modulation in triple-negative breast cancer cells

(2020) Lívia C. Ferreira et al.   PLoS One

Effects of miR-34b/miR-892a Upregulation and Inhibition of ABCB1/ABCB4 on Melatonin-Induced Apoptosis in VCR-Resistant Oral Cancer Cells

(2020) Ming-Ju Hsieh et al.   Molecular Therapy-Nucleic Acids

Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells

(2020) Wen-Jing Hsu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication—Potential Implication of Sirtuins

(2020) Jasmina Dimitrova-Shumkovska et al.   Marine Drugs

Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance

(2020) María Elena Reyes et al.   Marine Drugs

The Natural Product Fucoidan Inhibits Proliferation and Induces Apoptosis of Human Ovarian Cancer Cells: Focus on the PI3K/Akt Signaling Pathway

(2020) Shuhan Liu et al.   Cancer Management and Research

Fucoidan-based, tumor-activated nanoplatform for overcoming hypoxia and enhancing photodynamic therapy and antitumor immunity

(2020) Chu-Hung Chung et al.   BIOMATERIALS

The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs

(2020) Yuanyuan Wang et al.   International Journal of Nanomedicine

Melatonin Prevents Brain Damage and Neurocognitive Impairment Induced by Plasmodium Berghei ANKA Infection in Murine Model of Cerebral Malaria

(2020) Brenda Jaqueline de Azevedo Ataide et al.   Frontiers in Cellular and Infection Microbiology

Tailored elasticity combined with biomimetic surface promotes nanoparticle transcytosis to overcome mucosal epithelial barrier

(2020) Yaxian Zheng et al.   BIOMATERIALS

Characterization of pH-sensitive chitosan/hydroxypropyl methylcellulose composite nanoparticles for delivery of melatonin in cancer therapy

(2020) Hessam Jafari et al.   MATERIALS LETTERS

Fucoidan-coated nanoparticles target radiation-induced P-selectin to enhance chemoradiotherapy in murine colorectal cancer

(2020) Allison N. DuRoss et al.   CANCER LETTERS

Melatonin and doxorubicin co-delivered via a functionalized graphene-dendrimeric system enhances apoptosis of osteosarcoma cells

(2020) Guangfeng Niu et al.   Materials Science & Engineering C-Materials for Biological Applications

Melatonin suppresses lung cancer metastasis by inhibition of epithelial–mesenchymal transition through targeting to Twist

(2019) Chia-Chia Chao et al.   CLINICAL SCIENCE

Nanoparticles: Oral Delivery for Protein and Peptide Drugs

(2019) Shu-jun Cao et al.   AAPS PHARMSCITECH

Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge

(2019) Nedeljković et al.   Cells

The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review

(2019) Masoud Najafi et al.   LIFE SCIENCES

Melatonin Regulates Breast Cancer Progression by the lnc010561/miR-30/FKBP3 Axis

(2019) Peng Liu et al.   Molecular Therapy-Nucleic Acids

Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats

(2018) Olga Pozharitskaya et al.   Marine Drugs

Cyclodextrin/chitosan nanoparticles for oral ovalbumin delivery: Preparation, characterization and intestinal mucosal immunity in mice

(2018) Muye He et al.   Asian Journal of Pharmaceutical Sciences

Promising Antineoplastic Actions of Melatonin

(2018) Gaia Favero et al.   Frontiers in Pharmacology

Laminaria Japonica Polysaccharides effectively inhibited the growth of nasopharyngeal carcinoma cells in vivo and in vitro study

(2017) Manli Zeng et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial

(2017) Hsiang-Lin Tsai et al.   Marine Drugs

Melatonin-induced KiSS1 expression inhibits triple-negative breast cancer cell invasiveness

(2017) Tae-Hun Kim et al.   Oncology Letters

Melatonin for the prevention and treatment of cancer

(2017) Ya Li et al.   Oncotarget

Melatonin Regulates Angiogenic Factors under Hypoxia in Breast Cancer Cell Lines

(2016) Bruna Victorasso Jardim-Perassi et al.   Anti-Cancer Agents in Medicinal Chemistry

Sustained release of melatonin: A novel approach in elevating efficacy of tamoxifen in breast cancer treatment

(2016) Mehdi Sabzichi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

A review of the protective role of melatonin during phosphine-induced cardiotoxicity: focus on mitochondrial dysfunction, oxidative stress and apoptosis

(2016) Mohammad Hossein Asghari et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

(2016) Y. Shamay et al.   Science Translational Medicine

Effects of melatonin on HIF-1α and VEGF expression and on the invasive properties of hepatocarcinoma cells

(2016) JUCIMARA COLOMBO et al.   Oncology Letters

A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes

(2014) Wendy Y. Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells

(2013) V Martín et al.   BRITISH JOURNAL OF CANCER

Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells

(2013) Zhongyuan Zhang et al.   Marine Drugs

Beyond the Basics: The Differential Effects of Demographics and Hepatitis Status on Treatment Outcome in Hepatocellular Carcinoma

(2013) Ahmed O. Kaseb   ONCOLOGY

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

(2011) Marcel Tutor Ale et al.   Marine Drugs

Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer

(2011) MASAHIDE IKEGUCHI et al.   Oncology Letters

Targeted delivery of chitosan nanoparticles to Peyer’s patch using M cell-homing peptide selected by phage display technique

(2010) Mi-Kyong Yoo et al.   BIOMATERIALS

Transport of chitosan–DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes

(2009) Irina Kadiyala et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Fucoidan: Structure and Bioactivity

(2008) Bo Li et al.   MOLECULES