Tailored elasticity combined with biomimetic surface promotes nanoparticle transcytosis to overcome mucosal epithelial barrier

Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions

(2020) Xiangfei Han et al.   Nature Nanotechnology

State-of-the-Art and Future Challenges of UV Curable Polymer-Based Smart Materials for Printing Technologies

(2019) Cristian Mendes-Felipe et al.   Advanced Materials Technologies

An ingestible self-orienting system for oral delivery of macromolecules

(2019) Alex Abramson et al.   SCIENCE

Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels

(2019) Miaorong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase‐Changeable Nanoemulsions for Oral Delivery of a Therapeutic Peptide: Toward Targeting the Pancreas for Antidiabetic Treatments Using Lymphatic Transport

(2019) Po‐Yen Lin et al.   ADVANCED FUNCTIONAL MATERIALS

Transferrin Functionization Elevates Transcytosis of Nanogranules across Epithelium by Triggering Polarity-Associated Transport Flow and Positive Cellular Feedback Loop

(2019) Dan Yang et al.   ACS Nano

Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery

(2019) Zhuo Dai et al.   ACS Nano

Role of Nanoparticle Mechanical Properties in Cancer Drug Delivery

(2019) Yue Hui et al.   ACS Nano

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Intestinal Mucin Induces More Endocytosis but Less Transcytosis of Nanoparticles across Enterocytes by Triggering Nanoclustering and Strengthening the Retrograde Pathway

(2018) Dan Yang et al.   ACS Applied Materials & Interfaces

Biomimetic Viruslike and Charge Reversible Nanoparticles to Sequentially Overcome Mucus and Epithelial Barriers for Oral Insulin Delivery

(2018) Jiawei Wu et al.   ACS Applied Materials & Interfaces

Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting

(2018) Yue Hui et al.   ACS Nano

Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties

(2018) Lei Wu et al.   ADVANCED DRUG DELIVERY REVIEWS

Receptor mediated transcytosis in biological barrier: The influence of receptor character and their ligand density on the transmembrane pathway of active-targeting nanocarriers

(2018) Xiaoning Song et al.   BIOMATERIALS

Ionic liquids for oral insulin delivery

(2018) Amrita Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers

(2018) Miaorong Yu et al.   Nature Communications

Nanoparticle elasticity directs tumor uptake

(2018) Peng Guo et al.   Nature Communications

Iron-mimic peptide converts transferrin from foe to friend for orally targeting insulin delivery

(2018) Min Liu et al.   Journal of Materials Chemistry B

Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway

(2018) Yaxian Zheng et al.   ACS Applied Materials & Interfaces

Transport Mechanisms of Butyrate Modified Nanoparticles: Insight into “Easy Entry, Hard Transcytosis” of Active Targeting System in Oral Administration

(2018) Lei Wu et al.   MOLECULAR PHARMACEUTICS

Membrane Wrapping Efficiency of Elastic Nanoparticles during Endocytosis: Size and Shape Matter

(2018) Zhiqiang Shen et al.   ACS Nano

Advances in particle shape engineering for improved drug delivery

(2018) Yiwei Yang et al.   DRUG DISCOVERY TODAY

Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

(2018) Stephen T. Buckley et al.   Science Translational Medicine

Polarized Exocytosis

(2017) Jingwen Zeng et al.   Cold Spring Harbor Perspectives in Biology

Regulation profile of the intestinal peptide transporter 1 (PepT1)

(2017) Chun-Yang Wang et al.   Drug Design Development and Therapy

A strategy for developing effective orally-delivered nanoparticles through modulation of the surface “hydrophilicity/hydrophobicity balance”

(2017) Yi Cui et al.   Journal of Materials Chemistry B

Enhanced Oral Delivery of Protein Drugs Using Zwitterion-Functionalized Nanoparticles to Overcome both the Diffusion and Absorption Barriers

(2016) Wei Shan et al.   ACS Applied Materials & Interfaces

Transport Mechanisms of Solid Lipid Nanoparticles across Caco-2 Cell Monolayers and their Related Cytotoxicology

(2016) Gui-Hong Chai et al.   ACS Applied Materials & Interfaces

Intracellular transport of nanocarriers across the intestinal epithelium

(2016) Weiwei Fan et al.   DRUG DISCOVERY TODAY

Efficient mucus permeation and tight junction opening by dissociable “mucus-inert” agent coated trimethyl chitosan nanoparticles for oral insulin delivery

(2016) Min Liu et al.   JOURNAL OF CONTROLLED RELEASE

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

(2016) Amrita Banerjee et al.   JOURNAL OF CONTROLLED RELEASE

Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues

(2016) Miaorong Yu et al.   NANO LETTERS

Overcoming the Diffusion Barrier of Mucus and Absorption Barrier of Epithelium by Self-Assembled Nanoparticles for Oral Delivery of Insulin

(2015) Wei Shan et al.   ACS Nano

Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis, and Targeting

(2015) Aaron C. Anselmo et al.   ACS Nano

Tunable Rigidity of (Polymeric Core)-(Lipid Shell) Nanoparticles for Regulated Cellular Uptake

(2014) Jiashu Sun et al.   ADVANCED MATERIALS

Stiffness-Dependent In Vitro Uptake and Lysosomal Acidification of Colloidal Particles

(2014) Raimo Hartmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms of Nanoparticle Internalization and Transport Across an Intestinal Epithelial Cell Model: Effect of Size and Surface Charge

(2014) Azzah M. Bannunah et al.   MOLECULAR PHARMACEUTICS

Effect of Polyplex Morphology on Cellular Uptake, Intracellular Trafficking, and Transgene Expression

(2013) Julie Shi et al.   ACS Nano

The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells

(2013) Bing He et al.   BIOMATERIALS

Influence of nanoparticle–membrane electrostatic interactions on membrane fluidity and bending elasticity

(2013) Poornima Budime Santhosh et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Endothelial cell and model membranes respond to shear stress by rapidly decreasing the order of their lipid phases

(2013) K. Yamamoto et al.   JOURNAL OF CELL SCIENCE

Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation

(2012) Lei Zhang et al.   ACS Nano

Transferrin receptor specific nanocarriers conjugated with functional 7peptide for oral drug delivery

(2012) Wenwen Du et al.   BIOMATERIALS

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

(2011) Laura M. Ensign et al.   ADVANCED DRUG DELIVERY REVIEWS

Uniform zwitterionic polymer hydrogels with a nonfouling and functionalizable crosslinker using photopolymerization

(2011) Louisa R. Carr et al.   BIOMATERIALS

Everted gut sac model as a tool in pharmaceutical research: limitations and applications

(2011) Mohd Aftab Alam et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Functionalizable and nonfouling zwitterionic carboxybetaine hydrogels with a carboxybetaine dimethacrylate crosslinker

(2010) Louisa R. Carr et al.   BIOMATERIALS

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Barrier properties of mucus

(2008) Richard A. Cone   ADVANCED DRUG DELIVERY REVIEWS