Development of a Tag/Catcher-mediated capsid virus-like particle vaccine presenting the conserved Neisseria gonorrhoeae SliC antigen that blocks human lysozyme

First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2

(2023) Merel J Smit et al.   Lancet Microbe

Nanocarrier vaccine therapeutics for global infectious and chronic diseases

(2023) Faizan Zarreen Simnani et al.   Materials Today

Virus-like Particle Vaccines and Platforms for Vaccine Development

(2023) Milad Kheirvari et al.   Viruses-Basel

Recent Progress Towards a Gonococcal Vaccine

(2022) Stavros A. Maurakis et al.   Frontiers in Cellular and Infection Microbiology

Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae

(2022) Yingru Liu et al.   mSphere

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

(2021) Cyrielle Fougeroux et al.   Nature Communications

Comprehensive Bioinformatic Assessments of the Variability of Neisseria gonorrhoeae Vaccine Candidates

(2021) Benjamin I. Baarda et al.   mSphere

The Immunogenicity of Capsid-Like Particle Vaccines in Combination with Different Adjuvants Using Different Routes of Administration

(2021) Christoph M. Janitzek et al.   Vaccines

Efficacy of an Experimental Gonococcal Lipooligosaccharide Mimitope Vaccine Requires Terminal Complement

(2021) Lisa A Lewis et al.   JOURNAL OF INFECTIOUS DISEASES

Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines

(2020) Kara-Lee Aves et al.   Viruses-Basel

Gonococcal vaccines: Public health value and preferred product characteristics; report of a WHO global stakeholder consultation, January 2019

(2020) Sami L. Gottlieb et al.   VACCINE

A novel gonorrhea vaccine composed of MetQ lipoprotein formulated with CpG shortens experimental murine infection

(2020) Aleksandra E. Sikora et al.   VACCINE

Update to CDC's Treatment Guidelines for Gonococcal Infection, 2020

(2020) Sancta St. Cyr et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques

(2019) Amelia Escolano et al.   NATURE

Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016

(2019) Jane Rowley et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

(2019) Sunita Gulati et al.   PLOS BIOLOGY

Pfs230 and Pfs48/45 Fusion Proteins Elicit Strong Transmission-Blocking Antibody Responses Against Plasmodium falciparum

(2019) Susheel K. Singh et al.   Frontiers in Immunology

Virus like particles displaying major HDM allergen Der p 2 for prophylactic allergen immunotherapy

(2019) Tewarit Soongrung et al.   ALLERGY

Virus-like particle-display of the enterotoxigenic Escherichia coli heat-stable toxoid STh-A14T elicits neutralizing antibodies in mice

(2019) Morten L. Govasli et al.   VACCINE

Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine

(2019) Sunita Gulati et al.   mBio

Engineering a Virus-Like Particle as an Antigenic Platform for a Pfs47-Targeted Malaria Transmission-Blocking Vaccine

(2019) Lampouguin Yenkoidiok-Douti et al.   Scientific Reports

Progress Toward a Gonococcal Vaccine: The Way Forward

(2019) Michael W. Russell et al.   Frontiers in Immunology

Atypical, Yet Not Infrequent, Infections with Neisseria Species

(2019) Maria Victoria Humbert et al.   Pathogens

Biological feasibility and importance of a gonorrhea vaccine for global public health

(2018) Leah R. Vincent et al.   VACCINE

Explanations for the high potency of HPV prophylactic vaccines

(2018) John Schiller et al.   VACCINE

Development of new hepatitis E vaccines

(2018) Yufeng Cao et al.   Human Vaccines & Immunotherapeutics

SliC is a surface-displayed lipoprotein that is required for the anti-lysozyme strategy during Neisseria gonorrhoeae infection

(2018) Ryszard A. Zielke et al.   PLoS Pathogens

Neisseria gonorrhoeae employs two protein inhibitors to evade killing by human lysozyme

(2018) Stephanie A. Ragland et al.   PLoS Pathogens

Virus-like particle display of HER2 induces potent anti-cancer responses

(2018) Arianna Palladini et al.   OncoImmunology

Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of Neisseria gonorrhoeae

(2018) Yingru Liu et al.   mSphere

Virus-like particle vaccines: immunology and formulation for clinical translation

(2018) Braeden Donaldson et al.   Expert Review of Vaccines

Sexually Transmitted Infections in Pregnant Women: Integrating Screening and Treatment into Prenatal Care

(2018) Harold J. Lochner et al.   PEDIATRIC DRUGS

Quantitative Proteomics of the 2016 WHO Neisseria gonorrhoeae Reference Strains Surveys Vaccine Candidates and Antimicrobial Resistance Determinants

(2018) Fadi E. El-Rami et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomics, Bioinformatics and Structure-Function Antigen Mining For Gonorrhea Vaccines

(2018) Benjamin I. Baarda et al.   Frontiers in Immunology

Influence of protein fold stability on immunogenicity and its implications for vaccine design

(2017) Sandra Scheiblhofer et al.   Expert Review of Vaccines

Structural and functional insights into the role of BamD and BamE within the β-barrel assembly machinery inNeisseria gonorrhoeae

(2017) Aleksandra E. Sikora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental vaccine induces Th1-driven immune responses and resistance to Neisseria gonorrhoeae infection in a murine model

(2017) Y Liu et al.   Mucosal Immunology

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines

(2017) Emilie Alirol et al.   PLOS MEDICINE

Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor

(2017) María Victoria Humbert et al.   PLoS Pathogens

Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines

(2017) Darren B. Leneghan et al.   Scientific Reports

Immune Response of A Novel ATR-AP205-001 Conjugate Anti-hypertensive Vaccine

(2017) Xiajun Hu et al.   Scientific Reports

Vaccine technologies: From whole organisms to rationally designed protein assemblies

(2016) Christopher P. Karch et al.   BIOCHEMICAL PHARMACOLOGY

Structure of AP205 Coat Protein Reveals Circular Permutation in ssRNA Bacteriophages

(2016) Mihails Shishovs et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

(2016) Ryszard A. Zielke et al.   MOLECULAR & CELLULAR PROTEOMICS

Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea

(2016) Helen Fifer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bacterial superglue enables easy development of efficient virus-like particle based vaccines

(2016) Susan Thrane et al.   JOURNAL OF NANOBIOTECHNOLOGY

Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting

(2015) Lori Newman et al.   PLoS One

Quantitative Proteomics of theNeisseria GonorrhoeaeCell Envelope and Membrane Vesicles for the Discovery of Potential Therapeutic Targets

(2014) Ryszard A. Zielke et al.   MOLECULAR & CELLULAR PROTEOMICS

Durable Antibody Responses Following One Dose of the Bivalent Human Papillomavirus L1 Virus-Like Particle Vaccine in the Costa Rica Vaccine Trial

(2013) M. Safaeian et al.   Cancer Prevention Research

The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect

(2013) Samuele Calabro et al.   VACCINE

Virus-induced humoral immunity: on how B cell responses are initiated

(2013) Franziska Zabel et al.   Current Opinion in Virology

Immunization against a Saccharide Epitope Accelerates Clearance of Experimental Gonococcal Infection

(2013) Sunita Gulati et al.   PLoS Pathogens

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

(2012) B. Zakeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neisseria gonorrhoeae NspA Induces Specific Bactericidal and Opsonic Antibodies in Mice

(2011) Guocai Li et al.   Clinical and Vaccine Immunology

Combined Roles of Human IgG Subclass, Alternative Complement Pathway Activation, and Epitope Density in the Bactericidal Activity of Antibodies to Meningococcal Factor H Binding Protein

(2011) Serena Giuntini et al.   INFECTION AND IMMUNITY

Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection

(2011) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccines for Gonorrhea: Can We Rise to the Challenge?

(2011) Weiyan Zhu et al.   Frontiers in Microbiology

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

HPV vaccine: Cervarix

(2010) Anne Szarewski   EXPERT OPINION ON BIOLOGICAL THERAPY

Versatile Virus-Like Particle Carrier for Epitope Based Vaccines

(2010) Alain C. Tissot et al.   PLoS One

The coming of age of virus-like particle vaccines

(2008) Gary T. Jennings et al.   BIOLOGICAL CHEMISTRY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Strain-Specific Catalase Mutation and Mutation of the Metal-Binding Transporter Gene mntC Attenuate Neisseria gonorrhoeae In Vivo but Not by Increasing Susceptibility to Oxidative Killing by Phagocytes

(2008) H. Wu et al.   INFECTION AND IMMUNITY