TAM receptors in phagocytosis: Beyond the mere internalization of particles

Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk -associated retinitis pigmentosa

(2023) Maria E. Mercau et al.   Science Advances

Atherosclerosis: Recent developments

(2022) Johan L.M. Björkegren et al.   CELL

Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis

(2022) Li Zheng et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tissue-specific modifier alleles determine Mertk loss-of-function traits

(2022) Yemsratch T Akalu et al.   eLife

The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages

(2022) Lidia Jiménez-García et al.   Frontiers in Immunology

Region-Specific Characteristics of Astrocytes and Microglia: A Possible Involvement in Aging and Diseases

(2022) Jae Lee et al.   Cells

Microglia use TAM receptors to detect and engulf amyloid β plaques

(2021) Youtong Huang et al.   NATURE IMMUNOLOGY

Pro-Resolving Ligands Orchestrate Phagocytosis

(2021) Christa Decker et al.   Frontiers in Immunology

Role of sperm apoptosis and oxidative stress in male infertility: A narrative review

(2021) Asadollah Asadi et al.   International Journal of Reproductive Biomedicine

Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

(2020) Irune Diaz-Aparicio et al.   JOURNAL OF NEUROSCIENCE

Microglial Corpse Clearance: Lessons From Macrophages

(2020) Mar Márquez-Ropero et al.   Frontiers in Immunology

Postnatal Involution and Counter-Involution of the Thymus

(2020) Jennifer E. Cowan et al.   Frontiers in Immunology

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

(2020) Wei Tao et al.   Science Translational Medicine

SMART: recent updates, new developments and status in 2020

(2020) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis

(2020) Julia Vullings et al.   Journal of Immunology Research

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset

(2019) Richard Witas et al.   Journal of Immunology Research

Gas6/TAM Receptors in Systemic Lupus Erythematosus

(2019) Philip L. Cohen et al.   DISEASE MARKERS

Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis

(2019) Fei-Da Ni et al.   Cell Death & Disease

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

TAM receptors, Phosphatidylserine, inflammation, and Cancer

(2019) Tal Burstyn-Cohen et al.   Cell Communication and Signaling

Increased sMer, but not sAxl, sTyro3, and Gas6 relate with active disease in juvenile systemic lupus erythematosus

(2019) Bernadete L. Liphaus et al.   CLINICAL RHEUMATOLOGY

Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer’s disease

(2019) Dong Kyu Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response

(2018) Eric Ubil et al.   JOURNAL OF CLINICAL INVESTIGATION

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

(2018) Justyna Sosna et al.   Molecular Neurodegeneration

The role of TAM family receptors and ligands in the nervous system: From development to pathobiology

(2018) Bridget Shafit-Zagardo et al.   PHARMACOLOGY & THERAPEUTICS

Cell-intrinsic regulation of murine epidermal Langerhans cells by protein S

(2018) Yaara Tabib et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-Derived Protein S Facilitates Apoptotic Polymorphonuclear Cell Clearance by Resolution Phase Macrophages and Supports Their Reprogramming

(2018) Delphine Lumbroso et al.   Frontiers in Immunology

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis

(2018) Claire E. J. Waterborg et al.   PLoS One

Plasma sMer, sAxl and GAS6 levels correlate with disease activity and severity in lupus nephritis

(2018) Siwen Gong et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

TAM receptor signaling in development

(2017) Tal Burstyn-Cohen   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis

(2017) Amanda C. Doran et al.   JOURNAL OF CLINICAL INVESTIGATION

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

(2017) Bishuang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

(2017) Zhuoran Yin et al.   NEUROBIOLOGY OF AGING

Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury

(2017) Amanda Brosius Lutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands

(2017) Greg Lemke   TRENDS IN BIOCHEMICAL SCIENCES

Protein S Negatively Regulates Neural Stem Cell Self-Renewal through Bmi-1 Signaling

(2017) Katya Zelentsova-Levytskyi et al.   Frontiers in Molecular Neuroscience

Context-dependent compensation among phosphatidylserine-recognition receptors

(2017) Kristen K. Penberthy et al.   Scientific Reports

Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model

(2016) Sung Hoon Baik et al.   GLIA

Growth Arrest Specific 6 Concentration is Increased in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease

(2016) Pier Paolo Sainaghi et al.   JOURNAL OF ALZHEIMERS DISEASE

MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

(2016) Luke M. Healy et al.   JOURNAL OF IMMUNOLOGY

Protein S Regulates Neural Stem Cell Quiescence and Neurogenesis

(2016) Katya Zelentsova et al.   STEM CELLS

TAM Receptor Signaling in Immune Homeostasis

(2015) Carla V. Rothlin et al.   Annual Review of Immunology

AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas

(2015) Moshe Elkabets et al.   CANCER CELL

The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjögren's syndrome

(2015) Baodong Qin et al.   JOINT BONE SPINE

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

ALK inhibitor resistance in ALKF1174L-driven neuroblastoma is associated with AXL activation and induction of EMT

(2015) D N Debruyne et al.   ONCOGENE

Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells

(2015) I Dransfield et al.   Cell Death & Disease

Novel Axl-driven signaling pathway and molecular signature characterize high-grade ovarian cancer patients with poor clinical outcome

(2015) Katia Rea et al.   Oncotarget

Tyro3 Modulates Mertk-Associated Retinal Degeneration

(2015) Douglas Vollrath et al.   PLoS Genetics

Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation

(2014) Minh K. Nguyen et al.   BIOMATERIALS

Monocytes from Sjögren's syndrome patients display increased vasoactive intestinal peptide receptor 2 expression and impaired apoptotic cell phagocytosis

(2014) V. Hauk et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

(2014) Wen-I Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Auto-Oxidation and Oligomerization of Protein S on the Apoptotic Cell Surface Is Required for Mer Tyrosine Kinase-Mediated Phagocytosis of Apoptotic Cells

(2014) H. Uehara et al.   JOURNAL OF IMMUNOLOGY

Diversification of TAM receptor tyrosine kinase function

(2014) Anna Zagórska et al.   NATURE IMMUNOLOGY

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4

(2014) G. T. Tietjen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

(2014) Erin D Lew et al.   eLife

TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system

(2013) Angela M. Pierce et al.   BRAIN RESEARCH

Foam cells in atherosclerosis

(2013) Xiao-Hua Yu et al.   CLINICA CHIMICA ACTA

T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response

(2013) Eugenio A. Carrera Silva et al.   IMMUNITY

Breakdown of immune homeostasis in the testis of mice lacking Tyro3, Axl and Mer receptor tyrosine kinases

(2013) Yue Zhang et al.   IMMUNOLOGY AND CELL BIOLOGY

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

(2013) Rebecca S. Cook et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Phagocytosis executes delayed neuronal death after focal brain ischemia

(2013) J. J. Neher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

(2013) L. Bosurgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

α-Synuclein oligomers and clinical implications for Parkinson disease

(2012) Lorraine V. Kalia et al.   ANNALS OF NEUROLOGY

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Genetic Dissection of TAM Receptor-Ligand Interaction in Retinal Pigment Epithelial Cell Phagocytosis

(2012) Tal Burstyn-Cohen et al.   NEURON

Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina

(2012) L. Ruggiero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’

(2012) Guy C. Brown et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice

(2011) Agnès Fourcot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Retinitis Pigmentosa: Genes and Disease Mechanisms

(2011) Francesco Parmeggiani et al.   CURRENT GENOMICS

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

(2011) Jason G Weinger et al.   Journal of Neuroinflammation

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Constitutive exposure of phosphatidylserine on viable cells

(2011) K. Segawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

TAM receptors and the clearance of apoptotic cells

(2010) Greg Lemke et al.   Annals of the New York Academy of Sciences

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

TAM receptor signaling and autoimmune disease

(2010) Carla V Rothlin et al.   CURRENT OPINION IN IMMUNOLOGY

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

(2010) Kodi S. Ravichandran   JOURNAL OF EXPERIMENTAL MEDICINE

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo

(2010) Michael R. Elliott et al.   NATURE

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

(2010) K Vuoriluoto et al.   ONCOGENE

GAS6 Enhances Repair Following Cuprizone-Induced Demyelination

(2010) Vladislav Tsiperson et al.   PLoS One

Specification and Morphogenesis of Astrocytes

(2010) M. R. Freeman   SCIENCE

Generation and phenotypic analysis of protein S-deficient mice

(2009) F. Saller et al.   BLOOD

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

(2009) S. Loges et al.   BLOOD

TAM receptors are dispensable in the phagocytosis and killing of bacteria

(2009) By Julie C. Williams et al.   CELLULAR IMMUNOLOGY

Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis

(2009) Tal Burstyn-Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

CD36 and TLR Interactions in Inflammation and Phagocytosis: Implications for Malaria

(2009) L. K. Erdman et al.   JOURNAL OF IMMUNOLOGY

TAM Receptor Signalling and Demyelination

(2009) Michele D. Binder et al.   NEUROSIGNALS

Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice

(2009) Yongmei Chen et al.   REPRODUCTION

An evolutionary perspective on the mechanisms of immunosenescence

(2009) Daryl P. Shanley et al.   TRENDS IN IMMUNOLOGY

Defective Mer Receptor Tyrosine Kinase Signaling in Bone Marrow Cells Promotes Apoptotic Cell Accumulation and Accelerates Atherosclerosis

(2008) Hafid Ait-Oufella et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe −/− Mice

(2008) Edward Thorp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Axl and Growth Arrest Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with Glioblastoma Multiforme

(2008) M. Hutterer et al.   CLINICAL CANCER RESEARCH

Gas6 Deficiency Increases Oligodendrocyte Loss and Microglial Activation in Response to Cuprizone-Induced Demyelination

(2008) M. D. Binder et al.   JOURNAL OF NEUROSCIENCE

Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells

(2007) Weipeng Xiong et al.   REPRODUCTION