Article
Pharmacology & Pharmacy
Shoaib Shoaib, Saba Tufail, Mohammad Asif Sherwani, Nabiha Yusuf, Najmul Islam
Summary: Research indicates the potential therapeutic effect of phenethyl isothiocyanate against cervical cancer, causing apoptosis in cells and exhibiting synergistic effects with cisplatin.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maryam Farzaneh, Saadat Mokhtari, Seyedeh-Faezeh Moraveji, Forough-Azam Sayahpour, Najmeh Sadat Masoudi, Azam Javadi, Hamid Gourabi, Fereshteh Esfandiari
Summary: The study found that low concentrations of ZnO NPs may induce potential damage to spermatogonia, including chromosomal instability and DNA fragmentation. While short-term exposure did not result in cell death, prolonged exposure led to chromosomal instability. This highlights the importance of paying attention to the potential harmful effects of using ZnO NPs, especially in terms of long-lasting impacts on future generations.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Zhiming Shen, Min Chen, Yang Gao, Fangfang Dong, Changhuo Cen, Haowei Wu, Nan Wang, Xiuhong Cui, Chunsheng Han, Fei Gao
Summary: This study found that inactivation of Foxo1 after birth leads to germ cell loss and male infertility. Foxo1 is involved in the development of spermatogonia after birth, and its function is probably not regulated by the PI3K/PTEN signaling pathway.
Article
Biochemistry & Molecular Biology
Tanaporn Phetruen, Bloem van Dam, Sittinan Chanarat
Summary: This study investigates the effects of andrographolide in Saccharomyces cerevisiae and finds that it induces cytotoxicity and affects various cellular processes. Moreover, andrographolide also leads to the precipitation of biomolecules secreted from yeast cells, adding an additional source of stress. This study provides insights into the cellular effects and potential mechanisms of andrographolide.
Article
Agriculture, Dairy & Animal Science
Julian Valencia, Edgar Andres Alzate, German Gomez, Marc Yeste, Francisco Javier Henao
Summary: This study investigated the impact of temperature humidity index (THI) in different intertropical zones on the retention of cytoplasmic droplets (CDs), sperm function, and DNA integrity in boars. The results showed that boars from high THI farms had higher proportions of moderate and persistent CD incidence, and the presence of proximal CDs (PCDs) was negatively correlated with sperm DNA integrity. Joint analysis of both PCDs and distal CDs (DCDs) is necessary for routine sperm quality analyses.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Environmental Sciences
Xuelian Yang, Guangshen Shang, Xing Wang
Summary: The accumulation of sodium chloride in soil has detrimental effects on the survival of soil animals, such as reduced growth rate, cocoon production, and antioxidative enzyme activity in earthworms. NaCl stress also increases mortality rate, reactive oxygen species, and malondialdehyde activity level. Histological damage to the earthworm body wall and intestine, as well as DNA damage in the seminal vesicle and coelomocytes, were observed under NaCl stress. The diversity of earthworm gut microbiota decreased, while certain bacterial strains increased.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Guillermo Galdon, Nicholas A. Deebel, Nima Pourhabibi Zarandi, Mark J. Pettenati, Stanley Kogan, Christina Wang, Ronald S. Swerdloff, Anthony Atala, Yanhe Lue, Hooman Sadri-Ardekani
Summary: This study provides the first evidence of the loss of an extra sex chromosome during innate SSC culture, which is crucial for treating Klinefelter syndrome (KS) patients and preserving and propagating SSCs for future sperm production, either in vitro or in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Maria Lamminaho, Jouni Kujala, Hanna Peltonen, Maria Tengstrom, Veli-Matti Kosma, Arto Mannermaa
Summary: The study found that high cfDI is an independent prognostic factor for poor overall survival and breast cancer-specific survival in breast cancer cases, and its inclusion in logistic regression models improves predictive performance, suggesting its prognostic potential.
Article
Biochemistry & Molecular Biology
Elsa Cabrita, Tiziana Pacchiarini, Elvira Fatsini, Carmen Sarasquete, Maria Paz Herraez
Summary: In this study, the efficiency of four cryopreservation protocols for Senegalese sole germ cells was analyzed. It was found that protocols incorporating dimethyl sulfoxide (DMSO) as a cryoprotectant showed higher cell recovery and lower cell damage. Furthermore, cryopreservation of germ cells using L-15 + DMSO was demonstrated to have better incorporation capacity during early metamorphosis stages in Senegalese sole.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Veterinary Sciences
Raquel Ausejo, Juan Manuel Martinez, Noelia Mendoza, Alfonso Bolarin, M. Teresa Tejedor, Maria Victoria Falceto
Summary: This study aimed to compare different techniques for measuring sperm nuclear DNA fragmentation (sDF) and examine their relationship with boar reproductive value, classical spermiogram parameters, and reproductive results of the doses in sows. The findings indicate a significant correlation between sperm chromatin stability assay (SCSA) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay results. However, there was no correlation between sDF and fertility direct boar effect (DBE) index, total or progressive sperm motility. TUNEL measure showed a positive correlation with abnormal acrosomes and sperm chromatin dispersion test (SCD, Halomax (R)) measure showed a positive correlation with total sperm morphological abnormalities. No significant correlations were found between fertility or prolificacy results and sDF results with the different techniques.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Obstetrics & Gynecology
Elizabeth A. DeVilbiss, Lindsey A. Sjaarda, C. Matthew Peterson, James M. Hotaling, James L. Mills, Pauline Mendola, Douglas T. Carrell, Erica Johnstone, Zhen Chen, Neil J. Perkins, Ginny Ryan, Enrique F. Schisterman, Sunni L. Mumford
Summary: This study examined the association between semen parameters and live birth in couples seeking infertility treatment. The findings suggest that low morphology, motility, concentration, and total motile count are associated with fewer live births in couples undergoing ovulation induction or no treatment. For intrauterine insemination, low volume, concentration, count, and total motile count are associated with fewer live births. Only low morphology is important for live birth after in vitro fertilization.
FERTILITY AND STERILITY
(2022)
Article
Agriculture, Dairy & Animal Science
Victor Atencio-Garcia, Denia Padilla-Izquierdo, Juana Robles-Gonzalez, Martha Prieto-Guevara, Sandra Pardo-Carrasco, Jose Espinosa-Araujo
Summary: The aim of the study was to evaluate the damage suffered by cryopreserved semen of S cuspicaudus in mitochondria, plasmatic membranes, and DNA fragmentation with the use of ethylene glycol (EG) at different rates. The results showed that damage to the sperm increased after pre-freezing and thawing, affecting fertility and hatching rates. It was suggested that a cryoprotective solution composed of 6% EG, 6% glucose, and 5% skimmed milk powder is suitable for the cryopreservation of S. cuspicaudus semen.
Article
Veterinary Sciences
Bin Zhang, Yan Wang, Caihong Wu, Shulei Qiu, Xiaolan Chen, Bingyan Cai, Huimei Xie
Summary: In this study, the quality of boar spermatozoa at different steps of cryopreservation was evaluated, revealing that excessive ROS during freeze-thaw cycling can negatively affect sperm motility, plasma membrane integrity, mitochondrial activity, sperm chromatin structure, and apoptosis. Addition of the antioxidant NAC reversed these negative effects, highlighting the importance of ROS downregulation for successful frozen pig sperm production and livestock propagation.
BMC VETERINARY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yang Yang, Yu Chong, Mengyuan Chen, Wumin Dai, Xia Zhou, Yongling Ji, Guoqin Qiu, Xianghui Du
Summary: The study found that LDHA is overexpressed in NSCLC tissues and high LDHA expression is associated with poor prognosis and radioresistance in NSCLC patients. Inhibition of LDHA by oxamate increased radiosensitivity in NSCLC cell lines, induced apoptosis and autophagy, and altered cell cycle distribution. LDHA inhibition also led to ROS accumulation and ATP depletion, which may contribute to increased DNA damage and hinder DNA repair activity. The findings suggest that targeting LDHA may be a potential strategy to enhance radiotherapy efficacy in NSCLC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Min Yeong Kim, EunJin Bang, Sung-Kwon Moon, Seok Joong Yun, Wun-Jae Kim, Jeong Sook Noh, Gi-Young Kim, Suengmok Cho, Hyesook Lee, Yung Hyun Choi
Summary: The study found that phloroglucinol can protect human retinal pigment epithelium cells from oxidative damage, reduce apoptosis, and improve cell function by decreasing ROS production.
Article
Biochemistry & Molecular Biology
Mohammad Sabzikarian, Touraj Mahmoudi, Seidamir Pasha Tabaeian, Gholamreza Rezamand, Asadollah Asadi, Hamid Farahani, Hossein Nobakht, Reza Dabiri, Fariborz Mansour-Ghanaei, Faramarz Derakhshan, Mohammad Reza Zali
Summary: This study found an association between IGF1 gene variants and susceptibility to non-alcoholic fatty liver disease (NAFLD), with the IGF1rs6214 A allele and AA + AG genotype showing protective effects.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Entomology
Vahid Mahdavi, Hooshang Rafiee-Dastjerdi, Asadollah Asadi, Jabraeil Razmjou, Bahram Fathi Achachlouei
Summary: In this study, a new delivery system using electrospinning technique was developed to control P. operculella by incorporating Lippia citriodora essential oil into PVA nanofiber. The results showed that the nano-formulated essential oil was more toxic and the PVA-EO nanofibers were more durable compared to the pure essential oil. These novel systems could be used in integrated pest management programs for stored product pests.
INTERNATIONAL JOURNAL OF PEST MANAGEMENT
(2022)
Article
Chemistry, Multidisciplinary
Ramin Mohammadi-Aloucheh, Aziz Habibi-Yangjeh, Abolfazl Bayrami, Shima Rahim Pouran, Saeid Latifi-Navid, Asadollah Asadi
Summary: The study successfully synthesized zinc oxide and zinc oxide/silver samples using Vaccinium arctostaphylos L. fruit extract, and analyzed the characteristics of the fabricated materials through various tools. The antibacterial and anticancer activities of these samples were demonstrated, with the EXT/ZnO/Ag10 nanocomposite showing superior performance. The synergistic effects of ZnO, Ag, and extract biomolecules in the green-synthesized sample were suggested for combating bacteria and cancer cells.
Article
Cell Biology
Aida Karimian, Fereshteh Mir Mohammadrezaei, Akbar Hajizadeh Moghadam, Mohammad Hadi Bahadori, Marjan Ghorbani-Anarkooli, Asadollah Asadi, Arash Abdolmaleki
Summary: This study evaluated the effects of astaxanthin and the combined effects of astaxanthin and melatonin on breast cancer cells and non-tumoral breast cells. The results showed that astaxanthin had anti-tumoral effects on breast cancer cells and no cytotoxicity on non-cancerous cells. Additionally, the presence of astaxanthin enhanced the function of melatonin-induced cell death in breast cancer cells.
Review
Materials Science, Multidisciplinary
Milad Soluki, Arash Abdolmaleki, Fariba Mahmoudi, Asadollah Asadi, Maryam Moazedi
Summary: This review study evaluates the effects of low-level laser therapy on neurological disorders and finds that it improves mitochondrial function, activates transcription factors, suppresses inflammatory factors, and influences neurotrophic factors, leading to beneficial changes in neurorehabilitation.
JOURNAL OF LASER APPLICATIONS
(2022)
Article
Materials Science, Biomaterials
Saeideh Najafi, Seyed Mehdi Razavi, Maryam Khoshkam, Asadollah Asadi
Summary: This study investigates the effects of sulfur nanoparticles (SNPs) on the metabolic profiling of lettuce plants and finds significant changes in the levels of sugars, amino acids, fatty acids, and other metabolites in lettuce plants treated with different doses of SNPs. It is concluded that the use of SNPs at the appropriate concentration can improve the nutritional value of lettuce.
Article
Pharmacology & Pharmacy
Sevin Ferdowsi, Arash Abdolmaleki, Asadollah Asadi, Saber Zahri
Summary: This study aimed to investigate the effects of glibenclamide on nerve regeneration and functional improvement in a rat model of sciatic nerve injury. The results suggest that glibenclamide treatment promotes the recovery of motor and sensory function, possibly through increased neurotrophic factors and myelinated fiber formation.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Medical Laboratory Technology
Hossein Nobakht, Touraj Mahmoudi, Gholamreza Rezamand, Seidamir Pasha Tabaeian, Golnaz Jeddi, Asadollah Asadi, Hamid Farahani, Reza Dabiri, Fariborz Mansour-Ghanaei, Seyed Alireza Kaboli, Faramarz Derakhshan, Mohammad Reza Zali
Summary: This study found that the CC genotype of the IGF1 rs5742612 gene is associated with a 2.71-fold or 2.29-fold increased risk for NAFLD compared to the TT genotype or the TT+TC genotype, respectively.
LABORATORY MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Haider F. Al-Saedi, Yasin Panahi, Hussein A. Ghanimi, Arash Abdolmaleki, Asadollah Asadi
Summary: Nimodipine improves motor and sensory function in peripheral nerve injuries, possibly by increasing neurotrophic factor levels and suppressing inflammation.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sevin Ferdowsi, Arash Abdolmaleki, Asadollah Asadi, Saber Zahri
Summary: In a rat model of sciatic nerve injury, azithromycin treatment accelerated nerve regeneration and improved motor and sensory function recovery.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Davoud Malekzadeh, Asadollah Asadi, Arash Abdolmaleki, Gholamreza Dehghan
Summary: This study reports the therapeutic efficacy of fullerene C60 nanoparticles (FC60 NPs) in animals with aluminum-induced oxidative stress. The effects of FC60 NPs on neurobiochemical enzymes and oxidative parameters in brain and liver tissues were evaluated. Results showed a significant improvement in the markers, suggesting FC60 NPs as a potential therapeutic option for neurodegenerative diseases.
Article
Pharmacology & Pharmacy
Touraj Mahmoudi, Donya Ghorbani, Gholamreza Rezamand, Niloufar Dehestan, Golnaz Jeddi, Asadollah Asadi, Hossein Nobakht, Reza Dabiri, Hamid Farahani, Seidamir Pasha Tabaeian, Mohammad Reza Zali
Summary: This study explores the potential association between a certain variant of the NAMPT gene and nonalcoholic fatty liver disease (NAFLD). The results showed that individuals carrying this variant have a 45% decreased risk for NAFLD.
PERSONALIZED MEDICINE
(2023)
Article
Oncology
Vahid Asghariazar, Mohammad Amini, Zahra Pirdel, Roghayeh Fekri, Asadollah Asadi, Kazem Nejati-Koshki, Behzad Baradaran, Yasin Panahi
Summary: Although chemotherapy has extended the life expectancy of cancer patients, the toxic side effects of chemotherapy are still a major challenge. Organometallic compounds, specifically Schiff base copper complexes, have emerged as promising candidates for next-generation anticancer drugs due to their unique anticancer activities. This study examined the anticancer mechanisms of two copper(II) complexes, binuclear complex-1 and mononuclear complex-2. The results showed that complex-1 exhibited higher cytotoxicity than complex-2. Both complexes induced apoptosis and cell cycle arrest, but complex-1 showed a stronger effect on cell cycle arrest at the sub-G0/G1 phase. Furthermore, gene expression analysis revealed that only complex-1 induced the expression of p53 while both complexes induced Bcl-2 overexpression. Interestingly, both complexes inhibited cell migration through protease-independent pathways. This study highlights the potential of Cu-containing complexes in preventing cancer cell migration and suggests their use in novel therapeutic approaches.
Article
Anatomy & Morphology
Aida Nahumi, Maryam Peymani, Asadollah Asadi, Arash Abdolmaleki, Yassin Panahi
Summary: Tissue engineering research has focused on the characteristics and biocompatibility of decellularized sheep tracheal scaffolds, as well as the differentiation of Adipose-derived stem cells (AD-MSCs) into tracheal cells. The prepared scaffolds show potential for engineering applications and provide a suitable environment for stem cell differentiation. This research serves as a foundation for future studies on tracheal decellularization scaffolds and paves the way for their use in organ regeneration and clinical medicine.
Review
Nanoscience & Nanotechnology
Saman Roshancheshm, Asadollah Asadi, Seyedeh Mahdieh Khoshnazar, Arash Abdolmaleki, Zhikal Omar Khudhur, Shukur Wasman Smail
Summary: Extracellular vesicles (EVs), including exosomes, are small molecules produced by cells that can transfer functional biomolecules from one cell to another. Due to their similarities to the body's own cells and their nanoscale size, exosomes have become a promising strategy for targeted drug delivery.
NANOMEDICINE JOURNAL
(2022)
