Cancer cell-intrinsic mechanisms driving acquired immune tolerance

γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

(2023) Natasja L. de Vries et al.   NATURE

Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

(2023) Giorgio Gaglia et al.   CANCER CELL

Exploring the Immunogenicity of Noncanonical HLA-I Tumor Ligands Identified through Proteogenomics

(2023) Maria Lozano-Rabella et al.   CLINICAL CANCER RESEARCH

REFINE-Lung implements a novel multi-arm randomised trial design to address possible immunotherapy overtreatment

(2023) Ehsan Ghorani et al.   LANCET ONCOLOGY

The evolution of non-small cell lung cancer metastases in TRACERx

(2023) Maise Al Bakir et al.   NATURE

Genomic–transcriptomic evolution in lung cancer and metastasis

(2023) Carlos Martínez-Ruiz et al.   NATURE

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

(2023) Luis A. Rojas et al.   NATURE

Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways

(2023) Lavinia Spain et al.   Cancer Discovery

TCR-engineered T cell therapy in solid tumors: State of the art and perspectives

(2023) Estelle Baulu et al.   Science Advances

Safety and clinical activity of atezolizumab plus erlotinib in patients with non-small-cell lung cancer

(2023) C.M. Rudin et al.   ESMO Open

Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer

(2022) Naohiko Akimoto et al.   Frontiers in Immunology

Phase I/II study of the selective PI3Kβ inhibitor GSK2636771 in combination with pembrolizumab in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and PTEN loss.

(2022) Ecaterina Elena Dumbrava et al.   JOURNAL OF CLINICAL ONCOLOGY

OA03.06 CodeBreaK 100/101: First Report of Safety/Efficacy of Sotorasib in Combination with Pembrolizumab or Atezolizumab in Advanced KRAS p.G12C NSCLC

(2022) B.T. Li et al.   Journal of Thoracic Oncology

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

(2022) Juan Dubrot et al.   NATURE IMMUNOLOGY

Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response

(2021) Michelle von Locquenghien et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of the immune landscape of EGFR-mutant NSCLC identifies CD73/adenosine pathway as a potential therapeutic target

(2021) Xiuning Le et al.   Journal of Thoracic Oncology

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

(2021) Kevin Litchfield et al.   CELL

CD4 T cell dependent rejection of beta 2 microglobulin null mismatch repair deficient tumors

(2021) Giovanni Germano et al.   Cancer Discovery

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

(2021) Karthik Dhatchinamoorthy et al.   Frontiers in Immunology

IPEX Syndrome: Improved Knowledge of Immune Pathogenesis Empowers Diagnosis

(2021) Federica Barzaghi et al.   Frontiers in Pediatrics

PTEN loss correlates with T cell exclusion across human cancers

(2021) Ziying Lin et al.   BMC CANCER

Novel therapies emerging in oncology to target the TGF-β pathway

(2021) Byung-Gyu Kim et al.   Journal of Hematology & Oncology

Anti-angiogenic agents — overcoming tumour endothelial cell anergy and improving immunotherapy outcomes

(2021) Zowi R. Huinen et al.   Nature Reviews Clinical Oncology

Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution

(2021) Subramanian Venkatesan et al.   Cancer Discovery

Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

(2021) Roman V. Uzhachenko et al.   Cell Reports

1085P Ph I/II study of PI3K-β inhibitor GSK2636771 (G771) in combination with pembrolizumab (P) in patients (pts) with PTEN loss and melanoma or other advanced solid tumors

(2021) E. Burton et al.   ANNALS OF ONCOLOGY

Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

(2021) Megan L. Burger et al.   CELL

Spatially organized multicellular immune hubs in human colorectal cancer

(2021) Karin Pelka et al.   CELL

Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

(2021) Evangelos Giampazolias et al.   CELL

Phase I/II trial of palbociclib, pembrolizumab and letrozole in patients with hormone receptor-positive metastatic breast cancer

(2021) Yuan Yuan et al.   EUROPEAN JOURNAL OF CANCER

IMpower150 Final Overall Survival Analyses for Atezolizumab Plus Bevacizumab and Chemotherapy in First-Line Metastatic Nonsquamous NSCLC

(2021) Mark A. Socinski et al.   Journal of Thoracic Oncology

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial

(2021) Yelena Y Janjigian et al.   LANCET

NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

(2021) Emma L. Lewis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer

(2021) Dora Hammerl et al.   Nature Communications

Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

(2021) Brian D. Lehmann et al.   Nature Communications

IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function

(2021) Nikolaos Skartsis et al.   Frontiers in Immunology

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

(2020) Anna Śledzińska et al.   IMMUNITY

HALO 109-301: A randomized, double-blind, placebo-controlled, phase 3 study of pegvorhyaluronidase alfa (PEGPH20) + nab-paclitaxel/gemcitabine (AG) in patients (pts) with previously untreated hyaluronan (HA)-high metastatic pancreatic ductal adenocarcinoma (mPDA).

(2020) Margaret A. Tempero et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

(2020) Julianna Blagih et al.   Cell Reports

B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer

(2020) Bhalchandra Mirlekar et al.   Cancer Immunology Research

Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR-mutated non–small cell lung cancer

(2020) Eri Sugiyama et al.   Science Immunology

HLA-corrected tumor mutation burden and homologous recombination deficiency for the prediction of response to PD-(L)1 blockade in advanced non-small-cell lung cancer patients

(2020) J.H. Shim et al.   ANNALS OF ONCOLOGY

Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy

(2020) Jing Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

(2020) Khalid AbdulJabbar et al.   NATURE MEDICINE

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

CXCR3 Ligands in Cancer and Autoimmunity, Chemoattraction of Effector T Cells, and Beyond

(2020) Nathan Karin   Frontiers in Immunology

CCL5 mediates CD40-driven CD4+ T cell tumor infiltration and immunity

(2020) Austin P. Huffman et al.   JCI Insight

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

(2020) Daniel K. Wells et al.   CELL

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

(2020) Patrick A. Ott et al.   CELL

Pervasive chromosomal instability and karyotype order in tumour evolution

(2020) Thomas B. K. Watkins et al.   NATURE

Tumor-Derived cGAMP Regulates Activation of the Vasculature

(2020) Marco Campisi et al.   Frontiers in Immunology

Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer

(2020) Thierry André et al.   NEW ENGLAND JOURNAL OF MEDICINE

KrasG12D mutation contributes to regulatory T cell conversion through activation of the MEK/ERK pathway in pancreatic cancer

(2019) He Cheng et al.   CANCER LETTERS

WNT/β-catenin pathway activation correlates with immune exclusion across human cancers

(2019) Jason J. Luke et al.   CLINICAL CANCER RESEARCH

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas

(2019) Leland G. Richardson et al.   Translational Cancer Research

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

Neoantigen-directed immune escape in lung cancer evolution

(2019) Rachel Rosenthal et al.   NATURE

Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes

(2019) Hawley C. Pruitt et al.   MATRIX BIOLOGY

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

(2019) Wenting Liao et al.   CANCER CELL

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

(2019) Melvyn T. Chow et al.   IMMUNITY

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

(2019) Denarda Dangaj et al.   CANCER CELL

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

(2019) Max D. Wellenstein et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

(2019) Chen Yao et al.   NATURE IMMUNOLOGY

Clonal replacement of tumor-specific T cells following PD-1 blockade

(2019) Kathryn E. Yost et al.   NATURE MEDICINE

β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma

(2019) Marina Ruiz de Galarreta et al.   Cancer Discovery

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

(2019) Selena Vigano et al.   Frontiers in Immunology

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

(2019) Marian L. Burr et al.   CANCER CELL

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

(2019) Joseph L. Benci et al.   CELL

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

(2019) Yochai Wolf et al.   CELL

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

(2019) Andrew J. Freeman et al.   Cell Reports

WNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment

(2019) Xin Li et al.   Frontiers in Immunology

Galectin-1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance

(2019) Dhanya K. Nambiar et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens

(2019) Gerald P. Linette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens

(2019) Bas Weenink et al.   Scientific Reports

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

(2019) Caroline S. Jansen et al.   NATURE

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

(2018) Frederick Arce Vargas et al.   CANCER CELL

Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling

(2018) Mariana Terra et al.   CANCER RESEARCH

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

TP53,STK11andEGFRMutations Predict Tumor Immune Profile and the Response to anti-PD-1 in Lung Adenocarcinoma

(2018) Jerome Biton et al.   CLINICAL CANCER RESEARCH

Age and immunity: What is “immunosenescence”?

(2018) Graham Pawelec   EXPERIMENTAL GERONTOLOGY

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation

(2018) Boyoung Shin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis

(2018) Maxime De Laere et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms

(2018) Marco Bezzi et al.   NATURE MEDICINE

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

(2018) David F. McDermott et al.   NATURE MEDICINE

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC

(2018) Mark A. Socinski et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

(2018) Leena Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma

(2018) Scott J. Rodig et al.   Science Translational Medicine

Defining and Understanding Adaptive Resistance in Cancer Immunotherapy

(2018) Tae Kon Kim et al.   TRENDS IN IMMUNOLOGY

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells

(2018) Matthew A. Lakins et al.   Nature Communications

STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarcinoma

(2018) Ferdinandos Skoulidis et al.   Cancer Discovery

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

(2018) Theo A. Knijnenburg et al.   Cell Reports

Mechanisms of Tolerance Induction by Dendritic Cells In Vivo

(2018) Hitoshi Hasegawa et al.   Frontiers in Immunology

The Significance of Tumor Necrosis Factor Receptor Type II in CD8+ Regulatory T Cells and CD8+ Effector T Cells

(2018) Lin-Lin Ye et al.   Frontiers in Immunology

Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)

(2018) Patrick Danaher et al.   Journal for ImmunoTherapy of Cancer

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

(2018) André Kahles et al.   CANCER CELL

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

CCR4 Antagonists Inhibit Treg Trafficking into the Tumor Microenvironment

(2018) John M. Ketcham et al.   ACS Medicinal Chemistry Letters

HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy

(2018) Tiziana Triulzi et al.   OncoImmunology

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

(2018) Shunsuke Kitajima et al.   Cancer Discovery

Rejection of immunogenic tumor clones is limited by clonal fraction

(2018) Ron S Gejman et al.   eLife

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

(2017) Matthew A. Coelho et al.   IMMUNITY

Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma

(2017) Suzanne George et al.   IMMUNITY

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

(2017) Frederick Arce Vargas et al.   IMMUNITY

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

(2017) Gary Kohanbash et al.   JOURNAL OF CLINICAL INVESTIGATION

Checkpoint Inhibitors in Metastatic EGFR- Mutated Non–Small Cell Lung Cancer—A Meta-Analysis

(2017) Chee Khoon Lee et al.   Journal of Thoracic Oncology

Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia

(2017) Ehsan Ghorani et al.   LANCET

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

(2017) Marta Łuksza et al.   NATURE

Force interacts with macromolecular structure in activation of TGF-β

(2017) Xianchi Dong et al.   NATURE

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

(2017) Huipeng Li et al.   NATURE GENETICS

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

(2017) Jingjing Zhu et al.   Nature Communications

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

(2017) Antje Sucker et al.   Nature Communications

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

(2017) Manav Korpal et al.   Nature Communications

Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer

(2017) Tao Shen et al.   Oncotarget

The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy

(2017) Daniel Zingg et al.   Cell Reports

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression

(2017) Sebastian Marwitz et al.   Clinical Epigenetics

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma

(2017) Kevin Brennan et al.   Scientific Reports

Intratumoral Heterogeneity of the Epigenome

(2016) Tali Mazor et al.   CANCER CELL

IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer

(2016) M. S. Caetano et al.   CANCER RESEARCH

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

(2016) S. Koyama et al.   CANCER RESEARCH

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

(2016) Jianjun Gao et al.   CELL

EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer: A Retrospective Analysis

(2016) J. F. Gainor et al.   CLINICAL CANCER RESEARCH

Pan-cancer analysis of copy number changes in programmed death-ligand 1 (PD-L1, CD274) - associations with gene expression, mutational load, and survival

(2016) Jan Budczies et al.   GENES CHROMOSOMES & CANCER

Interleukin-35 Limits Anti-Tumor Immunity

(2016) Meghan E. Turnis et al.   IMMUNITY

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

PD-L1 Expression in Human Placentas and Gestational Trophoblastic Diseases

(2016) Emanuela Veras et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

(2016) Ran He et al.   NATURE

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

(2016) Eric Tran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma

(2016) Andrew H. Ko et al.   PANCREAS

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

(2016) Sayuri Yoshihama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

The "cancer immunogram"

(2016) C. U. Blank et al.   SCIENCE

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

(2016) N. McGranahan et al.   SCIENCE

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

(2016) P.-L. Chen et al.   Cancer Discovery

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

(2016) Valsamo Anagnostou et al.   Cancer Discovery

Mutant KRAS Conversion of Conventional T Cells into Regulatory T Cells

(2016) S. Zdanov et al.   Cancer Immunology Research

Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells

(2016) E. J. Brea et al.   Cancer Immunology Research

PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer

(2015) Nisha Nagarsheth et al.   CANCER RESEARCH

CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer

(2015) T. A. Karakasheva et al.   CANCER RESEARCH

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation

(2015) Hua Huang et al.   FASEB JOURNAL

Metastatic Melanoma Cells Evade Immune Detection by Silencing STAT1

(2015) JoDi Osborn et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

(2015) Dongjun Peng et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

(2015) Sachet A Shukla et al.   NATURE BIOTECHNOLOGY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

(2015) Julie Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints

(2015) M. E. Mikucki et al.   Nature Communications

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

(2015) C. Swanton et al.   Cancer Discovery

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

(2015) W. Peng et al.   Cancer Discovery

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration

(2015) Timothy J. Zumwalt et al.   Oncotarget

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways

(2015) Mohamed Abou El Hassan et al.   PLoS One

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity

(2014) Fei Duan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity

(2014) E. M. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression

(2014) A. J. Garcia et al.   MOLECULAR AND CELLULAR BIOLOGY

Abstract A72: A first-in-man Phase I study of the galectin-1 (gal-1) inhibitor OTX008 given subcutaneously as a single agent to patients with advanced solid tumors.

(2014) J.-P. Delord et al.   MOLECULAR CANCER THERAPEUTICS

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer

(2014) E Lemieux et al.   ONCOGENE

Correction: Frequent MAGE Mutations in Human Melanoma

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Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

(2014) M. Ammirante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sertoli cells – Immunological sentinels of spermatogenesis

(2014) Gurvinder Kaur et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

(2014) Carolina Cebrián et al.   Nature Communications

DNA methylation and nucleosome occupancy regulate the cancer germline antigen geneMAGEA11

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Oncology Meets Immunology: The Cancer-Immunity Cycle

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Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma

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PTEN functions as a melanoma tumor suppressor by promoting host immune response

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Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

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Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

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Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL

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Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

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Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

ICOS-Ligand Expression on Plasmacytoid Dendritic Cells Supports Breast Cancer Progression by Promoting the Accumulation of Immunosuppressive CD4+ T Cells

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Exploiting the Mutanome for Tumor Vaccination

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Plasmacytoid Dendritic Cells Promote Immunosuppression in Ovarian Cancer via ICOS Costimulation of Foxp3+ T-Regulatory Cells

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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

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Interleukin-21 (IL-21) synergizes with IL-2 to enhance T-cell receptor-induced human T-cell proliferation and counteracts IL-2/transforming growth factor-β-induced regulatory T-cell development

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Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy

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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

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Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Ovarian cancer progression is controlled by phenotypic changes in dendritic cells

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HER2/HER3 Signaling Regulates NK Cell-Mediated Cytotoxicity via MHC Class I Chain-Related Molecule A and B Expression in Human Breast Cancer Cell Lines

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The Living Eye "Disarms" Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition

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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

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Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

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Good news–bad news: the Yin and Yang of immune privilege in the eye

(2012) John V. Forrester et al.   Frontiers in Immunology

Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis

(2012) Sana Intidhar Labidi-Galy et al.   OncoImmunology

Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3+regulatory T cells and are associated with poor prognosis in breast cancer patients

(2012) Vanja Sisirak et al.   OncoImmunology

Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma

(2011) Trine O. Jensen et al.   CANCER

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

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The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma

(2011) Vegard Tjomsland et al.   Clinical & Developmental Immunology

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The PI3K p110δ Regulates Expression of CD38 on Regulatory T Cells

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The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

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PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network

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NF- B, and not MYCN, Regulates MHC Class I and Endoplasmic Reticulum Aminopeptidases in Human Neuroblastoma Cells

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T cell recognition of HLA-A2 restricted tumor antigens is impaired by the oncogene HER2

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

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Downregulation of tapasin expression in primary human oral squamous cell carcinoma: association with clinical outcome

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Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

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Tumor-Educated CD11b high Ia low Regulatory Dendritic Cells Suppress T Cell Response through Arginase I

(2009) Qiuyan Liu et al.   JOURNAL OF IMMUNOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

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(2008) Joel B. Nelson et al.   CANCER

Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells

(2008) M. R. Parkhurst et al.   CLINICAL CANCER RESEARCH

Antigen-Presentation Properties of Plasmacytoid Dendritic Cells

(2008) José A. Villadangos et al.   IMMUNITY

Plasmacytoid Dendritic Cells Mediate Oral Tolerance

(2008) Anne Goubier et al.   IMMUNITY

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

(2007) Ronald J Buckanovich et al.   NATURE MEDICINE