NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice

(2021) Ashley N. Suah et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

(2021) Mohamed S. Abdel-Hakeem et al.   NATURE IMMUNOLOGY

CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization

(2020) Jeremy M. Kinder et al.   Cell Reports

Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap

(2019) Jüri Reimand et al.   Nature Protocols

The pursuit of transplantation tolerance: new mechanistic insights

(2019) Pawan K. Gupta et al.   Cellular & Molecular Immunology

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

(2019) Francesca Alfei et al.   NATURE

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

(2019) Hyungseok Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Biologic mechanisms and clinical consequences of pregnancy alloimmunization

(2018) Paige M. Porrett   AMERICAN JOURNAL OF TRANSPLANTATION

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

(2018) Bertram Bengsch et al.   IMMUNITY

Transplantation preferentially induces a KLRG-1 lo CD127 hi differentiation program in antigen-specific CD8 + T cells

(2018) Alana M. Bozeman et al.   TRANSPLANT IMMUNOLOGY

Antibody-Mediated Rejection of Solid-Organ Allografts

(2018) Alexandre Loupy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influence of T Cell Coinhibitory Molecules on CD8+ Recall Responses

(2018) Anna B. Morris et al.   Frontiers in Immunology

Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN

(2017) Richard M. Powell et al.   JOURNAL OF IMMUNOLOGY

Relationship between CD4 Regulatory T Cells and Anergy In Vivo

(2017) Lokesh A. Kalekar et al.   JOURNAL OF IMMUNOLOGY

Transcriptional and epigenetic regulation of T cell hyporesponsiveness

(2017) Renata M. Pereira et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mixed signature of activation and dysfunction allows human decidual CD8+T cells to provide both tolerance and immunity

(2017) Anita van der Zwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Memory T Cells in Allograft Rejection and Tolerance

(2017) Gilles Benichou et al.   Frontiers in Immunology

The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases

(2016) Lee Ann Garrett-Sinha et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

(2016) Andrea Schietinger et al.   IMMUNITY

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Pregnancy promotes tolerance to future offspring by programming selective dysfunction in long-lived maternal T cells

(2016) Brendan M. Barton et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

Integrative analyses shed new light on human ribosomal protein gene regulation

(2016) Xin Li et al.   Scientific Reports

Effector, Memory, and Dysfunctional CD8+T Cell Fates in the Antitumor Immune Response

(2016) John Reiser et al.   Journal of Immunology Research

Placental exosomes in normal and complicated pregnancy

(2015) Murray D. Mitchell et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells

(2015) Pamela M. Odorizzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue microchimerism is increased during pregnancy: a human autopsy study

(2015) Emilie C. Rijnink et al.   MOLECULAR HUMAN REPRODUCTION

p53 and ribosome biogenesis stress: The essentials

(2014) Lior Golomb et al.   FEBS LETTERS

Cis-Acting Pathways Selectively Enforce the Non-Immunogenicity of Shed Placental Antigen for Maternal CD8 T Cells

(2014) Chin-Siean Tay et al.   PLoS One

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

Frequency and Determinants of Pregnancy-Induced Child-Specific Sensitization

(2013) G. Hönger et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Maternal CD4+ and CD8+ T Cell Tolerance Towards a Fetal Minor Histocompatibility Antigen in T Cell Receptor Transgenic Mice1

(2013) Antoine L. Perchellet et al.   BIOLOGY OF REPRODUCTION

Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity

(2013) Janelle A. Olson et al.   IMMUNITY

Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy

(2013) Yan Zheng et al.   MOLECULAR IMMUNOLOGY

Induction and stability of the anergic phenotype in T cells

(2013) Rut Valdor et al.   SEMINARS IN IMMUNOLOGY

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

(2013) Andrea Schietinger et al.   TRENDS IN IMMUNOLOGY

Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation

(2012) Rajesh R. Rao et al.   IMMUNITY

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

(2012) Travis A. Doering et al.   IMMUNITY

Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo

(2012) Yan Zheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fetal-Specific CD8+ Cytotoxic T Cell Responses Develop during Normal Human Pregnancy and Exhibit Broad Functional Capacity

(2012) D. Lissauer et al.   JOURNAL OF IMMUNOLOGY

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Induction of T cell anergy: integration of environmental cues and infectious tolerance

(2010) Pascal Chappert et al.   CURRENT OPINION IN IMMUNOLOGY

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

Evidence that CD8 T-cell homeostasis and function remain intact during murine pregnancy

(2010) Michelle T. Norton et al.   IMMUNOLOGY

Acquisition and presentation of follicular dendritic cell–bound antigen by lymph node–resident dendritic cells

(2010) Megan L. McCloskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Decidual Tissue Contains Differentiated CD8+ Effector-Memory T Cells with Unique Properties

(2010) T. Tilburgs et al.   JOURNAL OF IMMUNOLOGY

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Cross-Presentation of Male Seminal Fluid Antigens Elicits T Cell Activation to Initiate the Female Immune Response to Pregnancy

(2009) L. M. Moldenhauer et al.   JOURNAL OF IMMUNOLOGY

The effect of previous pregnancy and transfusion on HLA alloimmunization in blood donors: implications for a transfusion-related acute lung injury risk reduction strategy

(2009) Darrell J. Triulzi et al.   TRANSFUSION

Molecular regulation of T-cell anergy

(2008) Yan Zheng et al.   EMBO REPORTS

H-Y as a minor histocompatibility antigen in kidney transplantation: a retrospective cohort study

(2008) Alois Gratwohl et al.   LANCET

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY