IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells

(2021) Emilie Ronin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

(2020) Henry Kurniawan et al.   Cell Metabolism

FOXP3 mRNA Profile Prognostic of Acute T-cell–mediated Rejection and Human Kidney Allograft Survival

(2020) Danny Luan et al.   TRANSPLANTATION

TRAF6 directs FOXP3 localization and facilitates regulatory T‐cell function through K63‐linked ubiquitination

(2019) Xuhao Ni et al.   EMBO JOURNAL

A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt+Foxp3+ Tregs with Enhanced Suppressive Capacity

(2019) Julia Hagenstein et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells

(2019) Khalid Bin Dhuban et al.   Frontiers in Immunology

A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function

(2018) Mercedes Rincon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Revealing the specificity of regulatory T cells in murine autoimmune diabetes

(2018) Allyson Spence et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro

(2018) Paulo C. M. Urbano et al.   Frontiers in Immunology

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway

(2018) Jun Wang et al.   Scientific Reports

Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier

(2018) Jonathan H. Esensten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-6 Promotes T Cell Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORγt Expression

(2018) Bofeng Li et al.   JOURNAL OF IMMUNOLOGY

Transplant trials with Tregs: perils and promises

(2017) Qizhi Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor necrosis factor-α inhibitor-induced psoriasis: Systematic review of clinical features, histopathological findings, and management experience

(2017) Gabrielle Brown et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Interleukin 6 Present in Inflammatory Ascites from Advanced Epithelial Ovarian Cancer Patients Promotes Tumor Necrosis Factor Receptor 2-Expressing Regulatory T Cells

(2017) Nirmala Chandralega Kampan et al.   Frontiers in Immunology

Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells

(2017) Xuehui He et al.   Scientific Reports

TNF-α priming enhances CD4 + FoxP3 + regulatory T-cell suppressive function in murine GVHD prevention and treatment

(2016) Antonio Pierini et al.   BLOOD

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

(2016) M. Leclerc et al.   BLOOD

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression

(2016) Scott J. Patterson et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Suppressive activity of human regulatory T cells is maintained in the presence of TNF

(2016) Bruno Zaragoza et al.   NATURE MEDICINE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression

(2016) Emily R. Mercadante et al.   Frontiers in Immunology

A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells

(2016) Xuehui He et al.   PLoS One

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

(2015) H.-J. Kim et al.   SCIENCE

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation

(2014) Kate S. Smigiel et al.   IMMUNOLOGICAL REVIEWS

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

(2014) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

(2013) Jorg van Loosdregt et al.   IMMUNITY

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

(2013) Hong Nie et al.   NATURE MEDICINE

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

(2013) Yoshiaki Okubo et al.   Scientific Reports

Regulatory T-Cell Therapy in Transplantation: Moving to the Clinic

(2013) Q. Tang et al.   Cold Spring Harbor Perspectives in Medicine

Foxp3+Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production

(2012) Richard A. O'Connor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway

(2012) Qi Zhang et al.   Journal of Molecular Cell Biology

Mechanisms of Treg Suppression: Still a Long Way to Go

(2012) Dario A. A. Vignali   Frontiers in Immunology

TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40

(2011) Ryoko Hamano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity

(2011) Xin Chen et al.   FEBS LETTERS

Natural but Not Inducible Regulatory T Cells Require TNF-  Signaling for In Vivo Function

(2011) W. J. Housley et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

(2011) K. L. Hippen et al.   Science Translational Medicine

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF Activates a NF- B-Regulated Cellular Program in Human CD45RA- Regulatory T Cells that Modulates Their Suppressive Function

(2010) M. Nagar et al.   JOURNAL OF IMMUNOLOGY

IL-1 -Mediated Signals Preferentially Drive Conversion of Regulatory T Cells but Not Conventional T Cells into IL-17-Producing Cells

(2010) L. Li et al.   JOURNAL OF IMMUNOLOGY

The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells

(2010) M. Fujimoto et al.   JOURNAL OF IMMUNOLOGY

Cbl-b in T-cell activation

(2010) Magdalena Paolino et al.   Seminars in Immunopathology

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY

Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies

(2008) Zoe Waibler et al.   PLoS One

TGF-  and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3

(2008) A. Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

(2008) T. Korn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA