The testicular microvasculature in Klinefelter syndrome is immature with compromised integrity and characterized by excessive inflammatory cross-talk

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(2023) Mette Viuff et al.   Genome Medicine

Unique plasma metabolite signature for adolescents with Klinefelter syndrome reveals altered fatty acid metabolism

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Single-cell analysis of human testis aging and correlation with elevated body mass index

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Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner

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Sex chromosome aneuploidies give rise to changes in the circular RNA profile: A circular transcriptome-wide study of Turner and Klinefelter syndrome across different tissues

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Examining potential mechanisms of testicular fibrosis in Klinefelter Syndrome: A review of current understanding

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Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation

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Testicular Microvascular Flow Is Altered in Klinefelter Syndrome and Predicts Circulating Testosterone

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Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia

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Comparative single-cell analysis of biopsies clarifies pathogenic mechanisms in Klinefelter syndrome

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Integration and reanalysis of transcriptomics and methylomics data derived from blood and testis tissue of men with 47, XXY Klinefelter syndrome indicates the primary involvement of Sertoli cells in the testicular pathogenesis

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Testicular immune cells and vasculature in Klinefelter syndrome from childhood up to adulthood

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Testicular blood supply is altered in the 41,XXY* Klinefelter syndrome mouse model

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Prevalence of CBAVD in azoospermic men carrying pathogenic CFTR mutations ‐ evaluated in a cohort of 639 non‐vasectomized azoospermic men

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High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting

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Klinefelter syndrome - integrating genetics, neuropsychology and endocrinology

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When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome?

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Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis

(2018) Mei Wang et al.   Cell Stem Cell

DNA hypermethylation and differential gene expression associated with Klinefelter syndrome

(2018) Anne Skakkebæk et al.   Scientific Reports

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Testis development

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Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity

(2017) Kirstine Belling et al.   HUMAN MOLECULAR GENETICS

Use of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with cryptozoospermia: a meta-analysis

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Deregulation of sertoli and leydig cells function in patients with klinefelter syndrome as evidenced by testis transcriptome analysis

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Low testosterone in men predicts impaired arterial elasticity and microvascular function

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DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations

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Esm1 Modulates Endothelial Tip Cell Behavior and Vascular Permeability by Enhancing VEGF Bioavailability

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Intratesticular testosterone is increased in men with Klinefelter syndrome and may not be released into the bloodstream owing to altered testicular vascularization - a preliminary report

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Therapy of endocrine disease: Testicular function and fertility in men with Klinefelter syndrome: a review

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(2011) Cedric Ginestet   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY

Focal spermatogenesis originates in euploid germ cells in classical Klinefelter patients

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SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function

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