Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity

A scored human protein–protein interaction network to catalyze genomic interpretation

(2016) Taibo Li et al.   NATURE METHODS

Network biology concepts in complex disease comorbidities

(2016) Jessica Xin Hu et al.   NATURE REVIEWS GENETICS

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

The Klinefelter syndrome is associated with high recurrence of copy number variations on the X chromosome with a potential role in the clinical phenotype

(2016) M. S. Rocca et al.   Andrology

Klinefelter syndrome has increased brain responses to auditory stimuli and motor output, but not to visual stimuli or Stroop adaptation

(2016) Mikkel Wallentin et al.   NeuroImage-Clinical

Diagnosis trajectories of prior multi-morbidity predict sepsis mortality

(2016) Mette K. Beck et al.   Scientific Reports

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

Effects of aneuploidy on gene expression: implications for cancer

(2015) Milena Dürrbaum et al.   FEBS Journal

DISEASES: Text mining and data integration of disease–gene associations

(2015) Sune Pletscher-Frankild et al.   METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Uncovering disease-disease relationships through the incomplete interactome

(2015) J. Menche et al.   SCIENCE

mixtools: AnRPackage for Analyzing Finite Mixture Models

(2015) Tatiana Benaglia et al.   Journal of Statistical Software

FastRFunctions for Robust Correlations and Hierarchical Clustering

(2015) Peter Langfelder et al.   Journal of Statistical Software

The role of hypogonadism in Klinefelter Syndrome

(2014) Anders Bojesen et al.   ASIAN JOURNAL OF ANDROLOGY

Protein–protein interactions and genetic diseases: The interactome

(2014) Kasper Lage   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Biochemical systems identification by a random drift particle swarm optimization approach

(2014) Jun Sun et al.   BMC BIOINFORMATICS

Unique features of the transcriptional response to model aneuploidy in human cells

(2014) Milena Dürrbaum et al.   BMC GENOMICS

X chromosome regulation: diverse patterns in development, tissues and disease

(2014) Xinxian Deng et al.   NATURE REVIEWS GENETICS

Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data

(2014) Warren A. Kibbe et al.   NUCLEIC ACIDS RESEARCH

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients

(2014) Anders Boeck Jensen et al.   Nature Communications

Testosterone Induces Erythrocytosis via Increased Erythropoietin and Suppressed Hepcidin: Evidence for a New Erythropoietin/Hemoglobin Set Point

(2013) E. Bachman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

Aberrant Gene Expression Profiles in Pluripotent Stem Cells Induced from Fibroblasts of a Klinefelter Syndrome Patient

(2012) Yu Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detecting overlapping protein complexes in protein-protein interaction networks

(2012) Tamás Nepusz et al.   NATURE METHODS

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morbidity and mortality in Klinefelter syndrome (47,XXY)

(2011) Anders Bojesen et al.   ACTA PAEDIATRICA

Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experience

(2011) Lise Aksglaede et al.   ACTA PAEDIATRICA

Socioeconomic Trajectories Affect Mortality in Klinefelter Syndrome

(2011) Anders Bojesen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

The Danish National Patient Register

(2011) Elsebeth Lynge et al.   SCANDINAVIAN JOURNAL OF PUBLIC HEALTH

Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts

(2011) Francisco S. Roque et al.   PLoS Computational Biology

Promoter specific DNA methylation and gene expression of POMC in acutely underweight and recovered patients with anorexia nervosa

(2010) Stefan Ehrlich et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Novel genetic aspects of Klinefelter's syndrome

(2010) F. Tuttelmann et al.   MOLECULAR HUMAN REPRODUCTION

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Multiple taurodontism: the challenge of endodontic treatment

(2010) Bruno Marques-da-Silva et al.   Journal of Oral Science

Dynamic modularity in protein interaction networks predicts breast cancer outcome

(2009) Ian W Taylor et al.   NATURE BIOTECHNOLOGY

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH

Abnormal Sex Chromosome Constitution and Longitudinal Growth: Serum Levels of Insulin-Like Growth Factor (IGF)-I, IGF Binding Protein-3, Luteinizing Hormone, and Testosterone in 109 Males with 47,XXY, 47,XYY, or Sex-Determining Region of the Y Chromosome (SRY)-Positive 46,XX Karyotypes

(2007) Lise Aksglaede et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM