Tumor dormancy: EMT beyond invasion and metastasis

Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution

(2023) Federica Francescangeli et al.   CANCER AND METASTASIS REVIEWS

RHOJ controls EMT-associated resistance to chemotherapy

(2023) Maud Debaugnies et al.   NATURE

Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse

(2023) Frances K. Turrell et al.   Nature Cancer

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells

(2022) Lucia Borriello et al.   Nature Communications

Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1

(2022) Yingying Han et al.   Cell Reports

Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

(2022) Max A. K. Rätze et al.   ONCOGENE

Analysis of Dormancy-Associated Transcriptional Networks Reveals a Shared Quiescence Signature in Lung and Colorectal Cancer

(2022) Adriano Cuccu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

(2022) Patrick Aouad et al.   Nature Communications

YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer

(2021) Hazel M. Quinn et al.   CANCER RESEARCH

Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1

(2021) George Sflomos et al.   EMBO Molecular Medicine

Laboratory Models for Investigating Breast Cancer Therapy Resistance and Metastasis

(2021) Kevin Roarty et al.   Frontiers in Oncology

The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells

(2021) Igor L. Bado et al.   DEVELOPMENTAL CELL

Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

(2021) Ana Luísa Correia et al.   NATURE

Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States

(2021) Laura Bornes et al.   Journal of Clinical Medicine

Single Cell Analysis Unveils the Role of the Tumor Immune Microenvironment and Notch Signaling in Dormant Minimal Residual Disease

(2021) Mahnaz Janghorban et al.   CANCER RESEARCH

An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy

(2021) Bassem D. Khalil et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

(2020) Kari J. Kurppa et al.   CANCER CELL

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

(2020) Federica Francescangeli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

(2020) Marco Montagner et al.   NATURE CELL BIOLOGY

Hypoxia-mediated changes in bone marrow microenvironment in breast cancer dormancy

(2020) Alejandra Ferrer et al.   CANCER LETTERS

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis

(2020) Yan Li et al.   DEVELOPMENTAL CELL

Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1

(2020) Huimin Jiang et al.   Nature Communications

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency

(2020) Melanie Werner-Klein et al.   Nature Communications

The lingering mysteries of metastatic recurrence in breast cancer

(2020) Alessandra I. Riggio et al.   BRITISH JOURNAL OF CANCER

Are 90% of deaths from cancer caused by metastases?

(2019) Hanna Dillekås et al.   Cancer Medicine

Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients

(2018) Yvette A. H. Matser et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway

(2018) Li-Yuan Yu-Lee et al.   CANCER RESEARCH

Dormancy in cancer

(2018) Hiroko Endo et al.   CANCER SCIENCE

Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions

(2018) Maryse Fiche et al.   JOURNAL OF PATHOLOGY

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Early detection of multi-organ metastases

(2017) Miqin Zhang   Nature Biomedical Engineering

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response

(2016) George Sflomos et al.   CANCER CELL

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone

(2016) Sambad Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis of Epithelial to Mesenchymal Transition (EMT) Reveals Cross-talk between SNAIL and HDAC1 Proteins in Breast Cancer Cells

(2016) Camila de Souza Palma et al.   MOLECULAR & CELLULAR PROTEOMICS

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer

(2016) Ting Ni et al.   NATURE CELL BIOLOGY

TNFα-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2+ neutrophils

(2016) P F Yu et al.   ONCOGENE

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

(2015) Maria Soledad Sosa et al.   Nature Communications

Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

(2014) H. D. Tran et al.   CANCER RESEARCH

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

(2012) D. Gao et al.   CANCER RESEARCH

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population

(2012) Hasan Korkaya et al.   MOLECULAR CELL

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer

(2011) Nicole Vincent Jordan et al.   CELL CYCLE

Breast Cancer Adjuvant Therapy: Time to Consider Its Time-Dependent Effects

(2011) Ismail Jatoi et al.   JOURNAL OF CLINICAL ONCOLOGY

Framework models of tumor dormancy from patient-derived observations

(2010) Christoph A Klein   CURRENT OPINION IN GENETICS & DEVELOPMENT

Transmission of donor melanoma by organ transplantation

(2010) Dirk C Strauss et al.   LANCET ONCOLOGY

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Asymmetric Stem Cell Division

(2008) Juergen A. Knoblich   CELL

Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis

(2008) Christine E. Eyler et al.   JOURNAL OF CLINICAL ONCOLOGY