Laboratory Models for Investigating Breast Cancer Therapy Resistance and Metastasis

Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing

(2020) Ryan T. Davis et al.   NATURE CELL BIOLOGY

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

(2020) Richard Y. Ebright et al.   SCIENCE

ROR1 regulates chemoresistance in Breast Cancer via modulation of drug efflux pump ABCB1

(2020) Norman Fultang et al.   Scientific Reports

Identification of synergistic drug combinations using breast cancer patient-derived xenografts

(2020) Tia H. Turner et al.   Scientific Reports

In vitro Models of Breast Cancer Metastatic Dormancy

(2020) Marco Montagner et al.   Frontiers in Cell and Developmental Biology

Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer

(2020) Ze-Yi Zheng et al.   CANCER CELL

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

(2020) Shaokun Shu et al.   MOLECULAR CELL

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

(2020) Jennifer M. Rosenbluth et al.   Nature Communications

Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer

(2020) Jennifer Y. Ge et al.   Nature Communications

Cancer cells educate natural killer cells to a metastasis-promoting cell state

(2020) Isaac S. Chan et al.   JOURNAL OF CELL BIOLOGY

Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels

(2020) Antoine A. Khalil et al.   JOURNAL OF CELL BIOLOGY

Regulation of Collective Metastasis by Nanolumenal Signaling

(2020) Emma D. Wrenn et al.   CELL

Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

(2020) Olga Ilina et al.   NATURE CELL BIOLOGY

Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer

(2020) Reid T. Powell et al.   Scientific Reports

Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells

(2020) Cinzia Donato et al.   Cell Reports

Establishment of a 3D Co-culture With MDA-MB-231 Breast Cancer Cell Line and Patient-Derived Immune Cells for Application in the Development of Immunotherapies

(2020) Diana P. Saraiva et al.   Frontiers in Oncology

RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer

(2020) Derek Dustin et al.   BRITISH JOURNAL OF CANCER

A metastasis map of human cancer cell lines

(2020) Xin Jin et al.   NATURE

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

(2019) Patrick Carlson et al.   NATURE CELL BIOLOGY

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody

(2019) Suping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils escort circulating tumour cells to enable cell cycle progression

(2019) Barbara Maria Szczerba et al.   NATURE

Randomly distributed K14+ breast tumor cells polarize to the leading edge to direct collective migration in response to chemical and mechanical environmental cues

(2019) Gregory D Longmore et al.   CANCER RESEARCH

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

(2019) Kunihiko Hinohara et al.   CANCER CELL

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance

(2019) Micol Eleonora Fiori et al.   Molecular Cancer

The altered transcriptome and DNA methylation profiles of docetaxel resistance in breast cancer PDX models

(2019) Jorge Gómez-Miragaya et al.   MOLECULAR CANCER RESEARCH

Integrated analyses of murine breast cancer models reveal critical parallels with human disease

(2019) Jonathan P. Rennhack et al.   Nature Communications

Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis

(2019) Xiao Liu et al.   Science Advances

The Detection and Morphological Analysis of Circulating Tumor and Host Cells in Breast Cancer Xenograft Models

(2019) Cleris et al.   Cells

Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance

(2019) Maria Laura De Angelis et al.   Frontiers in Oncology

A unique morphological phenotype in chemoresistant triple negative breast cancer reveals metabolic reprogramming and PLIN4 expression as a molecular vulnerability

(2019) Isabelle Sirois et al.   MOLECULAR CANCER RESEARCH

Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms

(2019) Ik Sun Kim et al.   NATURE CELL BIOLOGY

B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer

(2019) Daniel P. Hollern et al.   CELL

Tumor Associated Fibroblasts Promote HER2-Targeted Therapy Resistance through FGFR2 Activation.

(2019) Patricia Fernandez-Nogueira et al.   CLINICAL CANCER RESEARCH

Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy

(2019) Sung Pil Hong et al.   Nature Communications

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF‑7 breast cancer cells

(2018) Ann‑Katrin Sommer et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

(2018) Sylwia Gawrzak et al.   NATURE CELL BIOLOGY

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation

(2018) Esther N. Arwert et al.   Cell Reports

Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence

(2018) Samir Tivari et al.   Cell Communication and Signaling

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

(2018) Tyler Risom et al.   Nature Communications

Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer

(2018) Jonathan T. Lei et al.   Cell Reports

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

(2018) Gloria V. Echeverria et al.   Nature Communications

Long-Term Prognostic Risk After Neoadjuvant Chemotherapy Associated With Residual Cancer Burden and Breast Cancer Subtype

(2017) W. Fraser Symmans et al.   JOURNAL OF CLINICAL ONCOLOGY

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

(2017) Lesley-Ann Martin et al.   Nature Communications

Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies

(2017) Hai Wang et al.   Nature Communications

Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population

(2017) Jorge Gómez-Miragaya et al.   Stem Cell Reports

ESR1 mutations affect anti-proliferative responses to tamoxifen through enhanced cross-talk with IGF signaling

(2016) Luca Gelsomino et al.   BREAST CANCER RESEARCH AND TREATMENT

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

(2016) Lacey E. Dobrolecki et al.   CANCER AND METASTASIS REVIEWS

Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors

(2016) Shom Goel et al.   CANCER CELL

Abstract 3328: MYC and MCL1 cooperatively promote chemotherapy-resistant cancer stem cells through regulation of mitochondrial biogenesis and oxidative phosphorylation

(2016) Kyung-min Lee et al.   CANCER RESEARCH

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

(2016) Richard Marcotte et al.   CELL

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

(2016) Alejandra Bruna et al.   CELL

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers

(2016) Adam D. Pfefferle et al.   Disease Models & Mechanisms

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

(2016) Petra ter Brugge et al.   JNCI-Journal of the National Cancer Institute

Abstract B16: Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

(2016) Shaokun Shu et al.   MOLECULAR CANCER RESEARCH

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

(2016) Thomas Welte et al.   NATURE CELL BIOLOGY

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

(2016) Kevin J. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death

(2016) Stephen T. Guest et al.   Oncotarget

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

(2016) Petra ter Brugge et al.   JNCI-Journal of the National Cancer Institute

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

(2016) Cuijuan Yu et al.   Jove-Journal of Visualized Experiments

The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells

(2015) Hai Wang et al.   CANCER CELL

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

Enhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis

(2015) Milica Pavlovic et al.   JNCI-Journal of the National Cancer Institute

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Enhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis

(2015) Milica Pavlovic et al.   JNCI-Journal of the National Cancer Institute

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

(2014) Peter Eirew et al.   NATURE

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

(2014) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration

(2014) J. Pignatelli et al.   Science Signaling

An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor

(2014) N. Murugaesu et al.   Cancer Discovery

KAT6A, a Chromatin Modifier from the 8p11-p12 Amplicon is a Candidate Oncogene in Luminal Breast Cancer

(2014) Brittany Turner-Ivey et al.   NEOPLASIA

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

(2013) X. Zhang et al.   CANCER RESEARCH

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Predicting Drug Responsiveness in Human Cancers Using Genetically Engineered Mice

(2013) J. Usary et al.   CLINICAL CANCER RESEARCH

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

(2013) Weiyi Toy et al.   NATURE GENETICS

An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation

(2013) J Wolf et al.   ONCOGENE

Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation

(2013) M Roh-Johnson et al.   ONCOGENE

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

(2013) Shunqiang Li et al.   Cell Reports

Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

(2013) Adam D Pfefferle et al.   GENOME BIOLOGY

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

(2012) Hua Gao et al.   CELL

Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance

(2012) Justin M Balko et al.   NATURE MEDICINE

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

(2012) K.-V. Nguyen-Ngoc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors

(2012) Janneke E. Jaspers et al.   Cancer Discovery

TGF /TNF -Mediated Epithelial-Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype

(2011) M. K. Asiedu et al.   CANCER RESEARCH

Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer

(2011) E. T. Roussos et al.   JOURNAL OF CELL SCIENCE

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells

(2011) J. I. Herschkowitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Reduced Dose and Intermittent Treatment with Lapatinib and Trastuzumab for Potent Blockade of the HER Pathway in HER2/neu-Overexpressing Breast Tumor Xenografts

(2010) Mothaffar F. Rimawi et al.   CLINICAL CANCER RESEARCH

Metastatic Behavior of Breast Cancer Subtypes

(2010) Hagen Kennecke et al.   JOURNAL OF CLINICAL ONCOLOGY

Phosphorylation of the mutant K303R estrogen receptor α at serine 305 affects aromatase inhibitor sensitivity

(2010) I Barone et al.   ONCOGENE

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Expression of the K303R Estrogen Receptor-  Breast Cancer Mutation Induces Resistance to an Aromatase Inhibitor via Addiction to the PI3K/Akt Kinase Pathway

(2009) I. Barone et al.   CANCER RESEARCH

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer

(2009) Pankaj Taneja et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

(2009) Joel S. Parker et al.   JOURNAL OF CLINICAL ONCOLOGY

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

(2009) Pierre Farmer et al.   NATURE MEDICINE

Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential

(2009) E. R. Andrechek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton

(2008) D. Barkan et al.   CANCER RESEARCH

Identification of Tumor-Initiating Cells in a p53-Null Mouse Model of Breast Cancer

(2008) M. Zhang et al.   CANCER RESEARCH

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

(2008) Lars Zender et al.   CELL

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

(2008) S. Rottenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA