Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1

The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network

(2018) Xiaochao Tan et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways

(2018) Fokhrul Hossain et al.   Frontiers in Oncology

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability

(2017) Anne-Pierre Morel et al.   NATURE MEDICINE

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

(2017) Meera Murgai et al.   NATURE MEDICINE

ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells

(2017) E M Langer et al.   ONCOGENE

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

(2017) Mitsuteru Natsuizaka et al.   Nature Communications

Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency

(2016) Jasmine M. De Cock et al.   CANCER RESEARCH

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer

(2016) Lingjia Liu et al.   PLoS One

ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

(2015) Peijing Zhang et al.   CELL CYCLE

Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche

(2015) Pegah Ghiabi et al.   Journal of Translational Medicine

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance

(2014) Zhongwei Cao et al.   CANCER CELL

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

VEGF-Mediated Angiogenesis Links EMT-Induced Cancer Stemness to Tumor Initiation

(2014) A. Fantozzi et al.   CANCER RESEARCH

MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis

(2014) Chi-Hong Chao et al.   JOURNAL OF CLINICAL INVESTIGATION

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

(2014) Peijing Zhang et al.   NATURE CELL BIOLOGY

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation

(2014) Naoya Hirata et al.   Nature Communications

Non-Canonical Notch Signaling in Cancer and Immunity

(2014) Furkan Ayaz et al.   Frontiers in Oncology

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

MiR-200b and miR-429 Function in Mouse Ovulation and Are Essential for Female Fertility

(2013) H. Hasuwa et al.   SCIENCE

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Epithelial–mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib

(2012) Amanda Kirane et al.   CARCINOGENESIS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ

(2012) S Jin et al.   ONCOGENE

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells

(2012) Suling Liu et al.   PLoS Genetics

Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling

(2011) Masahiro Sonoshita et al.   CANCER CELL

Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells

(2011) T. S. Zhu et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling

(2010) Zhaoli Liu et al.   CANCER BIOLOGY & THERAPY

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

Emerging role of Notch in stem cells and cancer

(2008) Zhiwei Wang et al.   CANCER LETTERS