Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer

Different Levels of Twist1 Regulate Skin Tumor Initiation, Stemness, and Progression

(2015) Benjamin Beck et al.   Cell Stem Cell

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice

(2015) L. Lan et al.   EMBO JOURNAL

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

(2015) K. Horvay et al.   EMBO JOURNAL

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Blocking of p53-Snail Binding, Promoted by Oncogenic K-Ras, Recovers p53 Expression and function

(2015) Sun-Hye Lee et al.   NEOPLASIA

Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages

(2014) Dennis Shin-Shian Hsu et al.   CANCER CELL

MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors

(2014) Liling Wan et al.   CANCER CELL

Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

(2014) H. D. Tran et al.   CANCER RESEARCH

Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion

(2014) J. Kim et al.   EMBO REPORTS

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

(2014) Q. Chen et al.   GENES & DEVELOPMENT

TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53 -mutated breast cancers

(2014) Balázs Győrffy et al.   Molecular Oncology

Identification of multipotent mammary stem cells by protein C receptor expression

(2014) Daisong Wang et al.   NATURE

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p53 in cell invasion, podosomes, and invadopodia

(2014) Alan S Mak   Cell Adhesion & Migration

Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β

(2014) Saehae Choi et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Nuclear Expression of Snail Is an Independent Negative Prognostic Factor in Human Breast Cancer

(2013) S. Muenst et al.   DISEASE MARKERS

Differential Role of Snail1 and Snail2 Zinc Fingers in E-cadherin Repression and Epithelial to Mesenchymal Transition

(2013) Ana Villarejo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Snail1-DNA-PKcs Protein-Protein Interface Sensitizes Cancer Cells and Inhibits Tumor Metastasis

(2013) Ga-Young Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis

(2013) R. P. Gajula et al.   MOLECULAR CANCER RESEARCH

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Mutual regulation between DNA-PKcs and snail1 leads to increased genomic instability and aggressive tumor characteristics

(2013) B-J Pyun et al.   Cell Death & Disease

A “Twist box” Code of p53 Inactivation: Twist box:p53 Interaction Promotes p53 Degradation

(2012) Sara Piccinin et al.   CANCER CELL

Paternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells

(2012) Baowei Jiao et al.   CELL

Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression

(2012) Z.-Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas

(2011) Joseph Geradts et al.   HUMAN PATHOLOGY

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma

(2010) Seung-Oe Lim et al.   FEBS LETTERS

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

(2009) R. Grant Rowe et al.   JOURNAL OF CELL BIOLOGY

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1

(2009) I. Ota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model

(2008) Hosein Kouros-Mehr et al.   CANCER CELL

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

(2008) A. J. Trimboli et al.   CANCER RESEARCH

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor

(2008) N. Herranz et al.   MOLECULAR AND CELLULAR BIOLOGY

Twist and p53 reciprocally regulate target genes via direct interaction

(2008) M Shiota et al.   ONCOGENE