Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells

(2022) Lucia Borriello et al.   Nature Communications

Stromal changes in the aged lung induce an emergence from melanoma dormancy

(2022) Mitchell E. Fane et al.   NATURE

Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade

(2022) Liam Jenkins et al.   CANCER RESEARCH

Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis

(2021) Hyunho Yoon et al.   ONCOGENE

Thorny ground, rocky soil: tissue-specific mechanisms of tumor dormancy and relapse

(2021) Andrea R. Lim et al.   SEMINARS IN CANCER BIOLOGY

Metastasis-Initiating Cells and Ecosystems

(2021) Joan Massagué et al.   Cancer Discovery

A single-cell and spatially resolved atlas of human breast cancers

(2021) Sunny Z. Wu et al.   NATURE GENETICS

Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

(2021) Ute Jungwirth et al.   Nature Communications

Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression

(2021) James W. Opzoomer et al.   Science Advances

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

(2020) Marco Montagner et al.   NATURE CELL BIOLOGY

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

The double edge sword of fibrosis in cancer

(2019) Chelsea Chandler et al.   Translational Research

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups

(2019) Oscar M. Rueda et al.   NATURE

Estimation of immune cell content in tumor using single-cell RNA-seq reference data

(2019) Xiaoqing Yu et al.   BMC CANCER

PDGF family function and prognostic value in tumor biology

(2018) Michael Bartoschek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PDGF-C and PDGF-D signaling in vascular diseases and animal models

(2018) Erika Folestad et al.   MOLECULAR ASPECTS OF MEDICINE

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

(2018) Ekrem Emrah Er et al.   NATURE CELL BIOLOGY

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling

(2018) Pernilla Roswall et al.   NATURE MEDICINE

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

(2018) Laura Vera-Ramirez et al.   Nature Communications

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

(2018) Brett A. Shook et al.   SCIENCE

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

(2017) C.-H. Heldin et al.   JOURNAL OF INTERNAL MEDICINE

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

(2017) Hongchao Pan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lung tissue gene-expression signature for the ageing lung in COPD

(2017) Maaike de Vries et al.   THORAX

Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis

(2017) Yuan Yang et al.   Oncotarget

Detecting the Molecular System Signatures of Idiopathic Pulmonary Fibrosis through Integrated Genomic Analysis

(2017) Indu Gangwar et al.   Scientific Reports

Hematopoietic Age at Onset of Triple-Negative Breast Cancer Dictates Disease Aggressiveness and Progression

(2016) T. Marsh et al.   CANCER RESEARCH

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

(2016) Amanpreet Kaur et al.   NATURE

Immunological off-target effects of imatinib

(2016) Laurence Zitvogel et al.   Nature Reviews Clinical Oncology

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

A Novel Genomic Signature with Translational Significance for Human Idiopathic Pulmonary Fibrosis

(2015) Yasmina Bauer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The prognostic impact of age in different molecular subtypes of breast cancer

(2015) Cornelia Liedtke et al.   BREAST CANCER RESEARCH AND TREATMENT

Gene expression profiles reveal molecular mechanisms involved in the progression and resolution of bleomycin-induced lung fibrosis

(2013) Sandra Cabrera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Bleomycin Induces Molecular Changes Directly Relevant to Idiopathic Pulmonary Fibrosis: A Model for “Active” Disease

(2013) Ruoqi Peng et al.   PLoS One

Paracrine signalling in colorectal liver metastases involving tumor cell-derived PDGF-C and hepatic stellate cell-derived PAK-2

(2012) Obul R. Bandapalli et al.   CLINICAL & EXPERIMENTAL METASTASIS

Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression

(2011) Newton J. Hurst et al.   BIOCHEMICAL JOURNAL

Frontline imatinib treatment of chronic myeloid leukemia: no impact of age on outcome, a survey by the GIMEMA CML Working Party

(2011) G. Gugliotta et al.   BLOOD

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Evaluation of tolerability and efficacy of imatinib mesylate in elderly patients with chronic phase CML: ELDERGLI study

(2011) Fermin M. Sánchez-Guijo et al.   LEUKEMIA RESEARCH

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway–dependent and PI3K pathway–independent mechanisms

(2011) Pixu Liu et al.   NATURE MEDICINE

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment

(2009) Yongping Crawford et al.   CANCER CELL

Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts

(2008) C. Anderberg et al.   CANCER RESEARCH

Role of platelet-derived growth factors in physiology and medicine

(2008) J. Andrae et al.   GENES & DEVELOPMENT

PDGF-C Is a Proinflammatory Cytokine that Mediates Renal Interstitial Fibrosis

(2008) F. Eitner et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY