Perspective: “Current Understanding of NADs Dynamics and Mechanisms of Disease”

Nucleoli and the nucleoli–centromere association are dynamic during normal development and in cancer

(2023) Aaron Rodrigues et al.   MOLECULAR BIOLOGY OF THE CELL

A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis

(2023) Han Zou et al.   NATURE CELL BIOLOGY

Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains

(2022) Cristiana Bersaglieri et al.   Nature Communications

An epigenome atlas of neural progenitors within the embryonic mouse forebrain

(2022) Christopher T. Rhodes et al.   Nature Communications

Dynamic chromosomal interactions and control of heterochromatin positioning by Ki‐67

(2022) Tom van Schaik et al.   EMBO REPORTS

3D Genome Plasticity in Normal and Diseased Neurodevelopment

(2022) Amara Plaza-Jennings et al.   Genes

Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development

(2021) Longzhi Tan et al.   CELL

Chromatin dynamics in human brain development and disease

(2021) Alfredo M. Valencia et al.   TRENDS IN CELL BIOLOGY

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression

(2021) Aynur Sönmez et al.   Cell Death & Disease

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

(2020) F. Kyle Satterstrom et al.   CELL

Distinct features of nucleolus-associated domains in mouse embryonic stem cells

(2020) Aizhan Bizhanova et al.   CHROMOSOMA

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation

(2020) J. Yuyang Lu et al.   Cell Reports

Heterozygous Variants in KMT2E Cause a Spectrum of Neurodevelopmental Disorders and Epilepsy

(2019) Anne H. O’Donnell-Luria et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phase-to-Phase With Nucleoli – Stress Responses, Protein Aggregation and Novel Roles of RNA

(2019) Leena Latonen   Frontiers in Cellular Neuroscience

The fetal origins of mental illness

(2019) Benjamin J.S. al-Haddad et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin

(2019) Anastassiia Vertii et al.   GENOME RESEARCH

Heterochromatin drives compartmentalization of inverted and conventional nuclei

(2019) Martin Falk et al.   NATURE

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

(2019) Maria Azkanaz et al.   eLife

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

(2019) Alexi Nott et al.   SCIENCE

Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus

(2018) Sofia A. Quinodoz et al.   CELL

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity

(2018) Michelle Percharde et al.   CELL

C9orf72-associated neurodegeneration in ALS-FTD: breaking new ground in ribosomal RNA and nucleolar dysfunction

(2018) Dustin Herrmann et al.   CELL AND TISSUE RESEARCH

Dynamic regulation of nucleolar architecture

(2018) Attila Németh et al.   CURRENT OPINION IN CELL BIOLOGY

Downregulation of ribosome biogenesis during early forebrain development

(2018) Kevin F Chau et al.   eLife

Pyrogens, a polypeptide produces fever by metabolic changes in hypothalamus: Mechanisms and detections

(2018) N Prajitha et al.   IMMUNOLOGY LETTERS

The p150N domain of chromatin assembly factor-1 regulates Ki-67 accumulation on the mitotic perichromosomal layer

(2017) Timothy D. Matheson et al.   MOLECULAR BIOLOGY OF THE CELL

Prenatal fever and autism risk

(2017) M Hornig et al.   MOLECULAR PSYCHIATRY

Febrile Seizures and Epilepsy: Association With Autism and Other Neurodevelopmental Disorders in the Child and Adolescent Twin Study in Sweden

(2017) Christopher Gillberg et al.   PEDIATRIC NEUROLOGY

Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation

(2017) Stefan Dillinger et al.   PLoS One

Epigenetic Modulation of Stem Cells in Neurodevelopment: The Role of Methylation and Acetylation

(2017) Martyna Podobinska et al.   Frontiers in Cellular Neuroscience

Dravet Syndrome: Diagnosis and Long-Term Course

(2016) Mary B. Connolly   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

The redundancy of the mammalian heterochromatic compartment

(2016) Joan C Ritland Politz et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Spatial genome organization and cognition

(2016) Prashanth Rajarajan et al.   NATURE REVIEWS NEUROSCIENCE

A redox mechanism underlying nucleolar stress sensing by nucleophosmin

(2016) Kai Yang et al.   Nature Communications

Identification of Nucleolus-Associated Chromatin Domains Reveals a Role for the Nucleolus in 3D Organization of the A. thaliana Genome

(2016) Frédéric Pontvianne et al.   Cell Reports

Maternal hospitalization with infection during pregnancy and risk of autism spectrum disorders

(2015) Brian K. Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

Determinants of mammalian nucleolar architecture

(2015) Katherine I. Farley et al.   CHROMOSOMA

Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity

(2015) Zhouteng Tao et al.   HUMAN MOLECULAR GENETICS

Centrosome-intrinsic mechanisms modulate centrosome integrity during fever

(2015) Anastassiia Vertii et al.   MOLECULAR BIOLOGY OF THE CELL

Prenatal Infection and Autism Spectrum Disorders in Childhood: A Population-Based Case-Control Study in Taiwan

(2015) Shao-You Fang et al.   PAEDIATRIC AND PERINATAL EPIDEMIOLOGY

Incidence of Dravet Syndrome in a US Population

(2015) Y. W. Wu et al.   PEDIATRICS

Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders

(2015) M. Sahin et al.   SCIENCE

lncRNA Maturation to Initiate Heterochromatin Formation in the Nucleolus Is Required for Exit from Pluripotency in ESCs

(2014) Nataša Savić et al.   Cell Stem Cell

The developmental transcriptome of the human brain

(2014) Andrew T.N. Tebbenkamp et al.   CURRENT OPINION IN NEUROLOGY

The maternal nucleolus plays a key role in centromere satellite maintenance during the oocyte to embryo transition

(2014) H. Fulka et al.   DEVELOPMENT

A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli

(2014) Corey L. Smith et al.   MOLECULAR BIOLOGY OF THE CELL

Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

(2014) Xinmei Wen et al.   NEURON

Systematic Review and Meta-analyses: Fever in Pregnancy and Health Impacts in the Offspring

(2014) J. W. Dreier et al.   PEDIATRICS

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

(2014) I. Kwon et al.   SCIENCE

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

(2013) Jop Kind et al.   CELL

Developmental Fate and Cellular Maturity Encoded in Human Regulatory DNA Landscapes

(2013) Andrew B. Stergachis et al.   CELL

Functional Genomics Reveals Dysregulation of Cortical Olfactory Receptors in Parkinson Disease: Novel Putative Chemoreceptors in the Human Brain

(2013) Paula Garcia-Esparcia et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model

(2013) B. Ansoleaga et al.   NEUROSCIENCE

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

3D-FISH analysis of embryonic nuclei in mouse highlights several abrupt changes of nuclear organization during preimplantation development

(2012) Tiphaine Aguirre-Lavin et al.   BMC DEVELOPMENTAL BIOLOGY

Nucleolar activity in neurodegenerative diseases: a missing piece of the puzzle?

(2012) Rosanna Parlato et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Parkinson's Disease DJ-1 L166P Alters rRNA Biogenesis by Exclusion of TTRAP from the Nucleolus and Sequestration into Cytoplasmic Aggregates via TRAF6

(2012) Sandra Vilotti et al.   PLoS One

Nucleolar Association and Transcriptional Inhibition through 5S rDNA in Mammals

(2012) Andrew M. Fedoriw et al.   PLoS Genetics

Nucleolar stress characterized by downregulation of nucleophosmin: A novel cause of neuronal degeneration

(2011) Esther Magdalena Marquez-Lona et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nucleolin Maintains Embryonic Stem Cell Self-renewal by Suppression of p53 Protein-dependent Pathway

(2011) Acong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nucleolus directly regulates p53 export and degradation

(2011) Mark T. Boyd et al.   JOURNAL OF CELL BIOLOGY

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

(2010) Daan Peric-Hupkes et al.   MOLECULAR CELL

Initial Genomics of the Human Nucleolus

(2010) Attila Németh et al.   PLoS Genetics

Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells

(2009) Bo Wen et al.   NATURE GENETICS

A role for a novel protein, nucleolin, in Parkinson's disease

(2009) W. Michael Caudle et al.   NEUROSCIENCE LETTERS

Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks

(2008) Polychronis Kotoglou et al.   CELL STRESS & CHAPERONES

Activation of an Endogenous Suicide Response after Perturbation of rRNA Synthesis Leads to Neurodegeneration in Mice

(2008) R. Parlato et al.   JOURNAL OF NEUROSCIENCE