3D Genome Plasticity in Normal and Diseased Neurodevelopment

Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia

(2022) Marianna Zazhytska et al.   CELL

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

(2022) Andrew C. Yang et al.   NATURE

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

(2022) Vassily Trubetskoy et al.   NATURE

Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains

(2022) Kiran Girdhar et al.   NATURE NEUROSCIENCE

Cohesin-dependence of neuronal gene expression relates to chromatin loop length

(2022) Lesly Calderon et al.   eLife

Cohesin-mediated loop anchors confine the locations of human replication origins

(2022) Daniel J. Emerson et al.   NATURE

Sex-specific multi-level 3D genome dynamics in the mouse brain

(2022) Devin Rocks et al.   Nature Communications

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice

(2021) Rafael Alcalá-Vida et al.   Nature Communications

3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis

(2021) Xin Luo et al.   CELL

Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics

(2021) Houda Belaghzal et al.   NATURE GENETICS

The molecular biology of FMRP: new insights into fragile X syndrome

(2021) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin

(2021) Felix D. Weiss et al.   Nature Communications

Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition

(2021) Sergio Espeso-Gil et al.   Frontiers in Molecular Neuroscience

Retrotransposons as Drivers of Mammalian Brain Evolution

(2021) Roberto Ferrari et al.   Life-Basel

Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk

(2021) Samuel K. Powell et al.   MOLECULAR PSYCHIATRY

Distinct nuclear compartment-associated genome architecture in the developing mammalian brain

(2021) Sajad Hamid Ahanger et al.   NATURE NEUROSCIENCE

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders

(2021) Benxia Hu et al.   Nature Communications

Cornelia de Lange Syndrome: From a Disease to a Broader Spectrum

(2021) Angelo Selicorni et al.   Genes

Single-cell epigenomics reveals mechanisms of human cortical development

(2021) Ryan S. Ziffra et al.   NATURE

A multimodal cell census and atlas of the mammalian primary motor cortex

(2021) et al.   NATURE

Cell-type specialization is encoded by specific chromatin topologies

(2021) Warren Winick-Ng et al.   NATURE

Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions

(2021) Sandhya Chandrasekaran et al.   Nature Communications

Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction

(2021) Jorine M. Eeftens et al.   Nature Communications

Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations

(2020) Daniel P. Howrigan et al.   NATURE NEUROSCIENCE

A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

(2020) Sergio Espeso-Gil et al.   Genome Medicine

On the relations of phase separation and Hi-C maps to epigenetics

(2020) Prim B. Singh et al.   Royal Society Open Science

Olfactory and Gustatory Dysfunction in Coronavirus Disease 19 (COVID-19)

(2020) Jan C Luers et al.   CLINICAL INFECTIOUS DISEASES

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles

(2020) Nancy Y. A. Sey et al.   NATURE NEUROSCIENCE

Expanded encyclopaedias of DNA elements in the human and mouse genomes

(2020) Jill E. Moore et al.   NATURE

Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble

(2020) Asaf Marco et al.   NATURE NEUROSCIENCE

SATB2‐LEMD2 interaction links nuclear shape plasticity to regulation of cognition‐related genes

(2020) Patrick Feurle et al.   EMBO JOURNAL

4D nucleome modeling

(2020) Marco Di Stefano et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Function and regulation of chromatin insulators in dynamic genome organization

(2019) Dahong Chen et al.   CURRENT OPINION IN CELL BIOLOGY

CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum

(2019) Enrico D. H. Konrad et al.   GENETICS IN MEDICINE

Genome-wide analysis of polymerase III–transcribed Alu elements suggests cell-type–specific enhancer function

(2019) Xiao-Ou Zhang et al.   GENOME RESEARCH

Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus

(2019) Jordi Fernandez-Albert et al.   NATURE NEUROSCIENCE

Nucleome Dynamics during Retinal Development

(2019) Jackie L. Norrie et al.   NEURON

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

(2019) Laufey Geirsdottir et al.   CELL

Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register

(2018) Rikke Hilker et al.   BIOLOGICAL PSYCHIATRY

Formation of Chromatin Subcompartments by Phase Separation

(2018) Fabian Erdel et al.   BIOPHYSICAL JOURNAL

Epigenetic maintenance of topological domains in the highly rearranged gibbon genome

(2018) Nathan H. Lazar et al.   GENOME RESEARCH

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome

(2018) Kiran Girdhar et al.   NATURE NEUROSCIENCE

Computational 3D genome modeling using Chrom3D

(2018) Jonas Paulsen et al.   Nature Protocols

Chromatin organization by an interplay of loop extrusion and compartmental segregation

(2018) Johannes Nuebler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease-Associated Short Tandem Repeats Co-localize with Chromatin Domain Boundaries

(2018) James H. Sun et al.   CELL

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk

(2018) Prashanth Rajarajan et al.   SCIENCE

Local and global chromatin interactions are altered by large genomic deletions associated with human brain development

(2018) Xianglong Zhang et al.   Nature Communications

HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

(2017) Christian Eggers et al.   JOURNAL OF NEUROLOGY

Two independent modes of chromatin organization revealed by cohesin removal

(2017) Wibke Schwarzer et al.   NATURE

The 4D nucleome project

(2017) Job Dekker et al.   NATURE

Chromosome conformation elucidates regulatory relationships in developing human brain

(2016) Hyejung Won et al.   NATURE

Erratum: Corrigendum: Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

(2015)   NATURE NEUROSCIENCE

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

(2015) Andrew E Jaffe et al.   NATURE NEUROSCIENCE

Gene Length Matters in Neurons

(2015) Mark J. Zylka et al.   NEURON

Comparative Hi-C Reveals that CTCF Underlies Evolution of Chromosomal Domain Architecture

(2015) Matteo Vietri Rudan et al.   Cell Reports

Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene

(2014) Atsushi Takata et al.   NEURON

A Role for Noncoding Variation in Schizophrenia

(2014) Panos Roussos et al.   Cell Reports

Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs

(2013) Matthew J. Hangauer et al.   PLoS Genetics

Nuclear Aggregation of Olfactory Receptor Genes Governs Their Monogenic Expression

(2012) E. Josephine Clowney et al.   CELL

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Spatial partitioning of the regulatory landscape of the X-inactivation centre

(2012) Elphège P. Nora et al.   NATURE

Human-Specific Histone Methylation Signatures at Transcription Start Sites in Prefrontal Neurons

(2012) Hennady P. Shulha et al.   PLOS BIOLOGY

The genomic landscape shaped by selection on transposable elements across 18 mouse strains

(2012) Christoffer Nellåker et al.   GENOME BIOLOGY

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY