Betulinic acid in the treatment of breast cancer: Application and mechanism progress
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Title
Betulinic acid in the treatment of breast cancer: Application and mechanism progress
Authors
Keywords
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Journal
Fitoterapia
Volume 169, Issue -, Pages 105617
Publisher
Elsevier BV
Online
2023-07-20
DOI
10.1016/j.fitote.2023.105617
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Note: Only part of the references are listed.- Mitochondrial Modulators: The Defender
- (2023) Emmanuel Makinde et al. Biomolecules
- Breast Cancer
- (2023) Elena Michaels et al. MEDICAL CLINICS OF NORTH AMERICA
- Self-Assembled Redox-Sensitive Polymeric Nanostructures Facilitate the Intracellular Delivery of Paclitaxel for Improved Breast Cancer Therapy
- (2023) Shalini Gautam et al. Molecular Pharmaceutics
- Breast cancer: presentation, investigation and management
- (2022) Chie Katsura et al. BRITISH JOURNAL OF HOSPITAL MEDICINE
- New insights into the discovery of drugs for triple-negative breast cancer metastasis
- (2022) Wanessa Fernanda Altei et al. Expert Opinion on Drug Discovery
- Targeting Apoptosis in Cancer
- (2022) Puneet Singh et al. Current Oncology Reports
- Betulinic acid self-assembled nanoparticles for effective treatment of glioblastoma
- (2022) Yong Li et al. JOURNAL OF NANOBIOTECHNOLOGY
- Breast Cancer Bone Metastasis: A Narrative Review of Emerging Targeted Drug Delivery Systems
- (2022) Huimin Shao et al. Cells
- NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition
- (2022) Sepideh Mirzaei et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer
- (2022) Andrea Lopez et al. Nature Communications
- Cyclin-Dependent Kinase 4/6 Inhibitors Against Breast Cancer
- (2022) Mohammed Al-Kassim Hassan et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Betulinic acid: A natural promising anticancer drug, current situation, and future perspectives
- (2022) Maniyamma Aswathy et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Preoperative Systemic Therapy for Breast Cancer
- (2022) Abhigna Kodali et al. SURGICAL CLINICS OF NORTH AMERICA
- The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer Subtypes
- (2022) Sayali S. Onkar et al. Cancer Discovery
- DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis
- (2021) Shannon J. McKie et al. BIOESSAYS
- Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review
- (2021) Justyna Żwawiak et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer
- (2021) Xun Bao et al. CTS-Clinical and Translational Science
- Chemical Strategies towards the Synthesis of Betulinic Acid and Its More Potent Antiprotozoal Analogues
- (2021) André Barreto Cunha et al. MOLECULES
- MicroRNAs and Their Roles in Breast Cancer Bone Metastasis
- (2021) Margherita Puppo et al. Current Osteoporosis Reports
- Pinus kesiya Royle ex Gordon induces apoptotic cell death in hepatocellular carcinoma HepG2 cell via intrinsic pathway by PARP and Topoisomerase I suppression
- (2021) Piman Pocasap et al. BIOMEDICINE & PHARMACOTHERAPY
- Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
- (2021) Hao Zhang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- A Review on Preparation of Betulinic Acid and Its Biological Activities
- (2021) Hanghang Lou et al. MOLECULES
- Role of betulinic acid derivative SH‑479 in triple negative breast cancer and bone microenvironment
- (2021) Liang Tang et al. Oncology Letters
- The presentation of brain metastases in melanoma, non-small cell lung cancer, and breast cancer and potential implications for screening brain MRIs
- (2021) Matthew N. Mills et al. BREAST CANCER RESEARCH AND TREATMENT
- Understanding breast cancer as a global health concern
- (2021) Louise Wilkinson et al. BRITISH JOURNAL OF RADIOLOGY
- The Potential of Natural Products in the Treatment of Triple-Negative Breast Cancer
- (2021) Danny Yu Jia Ke et al. CURRENT CANCER DRUG TARGETS
- Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation
- (2021) Ji-Hyang Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- OCT1 Is a Poor Prognostic Factor for Breast Cancer Patients and Promotes Cell Proliferation via Inducing NCAPH
- (2021) Takuya Ogura et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Clinical advances in PET–MRI for breast cancer
- (2021) Amy M Fowler et al. LANCET ONCOLOGY
- Network pharmacology: curing causal mechanisms instead of treating symptoms
- (2021) Cristian Nogales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Biotechnological production of betulinic acid and derivatives and their applications
- (2020) Tianyue An et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds
- (2020) Ana M. Barbosa et al. Cancers
- Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View
- (2020) Manuela Labbozzetta et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation
- (2020) Xiaodong Sun et al. TOXICOLOGY
- DNA damage control then and now: a matter of life or death
- (2020) David F. Albertini JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- Triple Negative Breast Cancer and Breast Epithelial Cells Differentially Reprogram Glucose and Lipid Metabolism upon Treatment with Triterpenic Acids
- (2020) Ângela R. Guerra et al. Biomolecules
- 3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere
- (2020) Prem Prakash Kushwaha et al. CHEMICO-BIOLOGICAL INTERACTIONS
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- (2020) Ruoning Wang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications
- (2020) Xiaobin Zeng et al. PHARMACOLOGICAL RESEARCH
- DNA Topoisomerases in Unicellular Pathogens: Structure, Function, and Druggability
- (2019) Somenath Roy Chowdhury et al. TRENDS IN BIOCHEMICAL SCIENCES
- Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment
- (2019) Ana C. Garrido-Castro et al. Cancer Discovery
- Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway
- (2019) Lin Jiao et al. BIOCHEMICAL PHARMACOLOGY
- Molecular Classification of Breast Cancer
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- (2019) Yifeng Zheng et al. Oxidative Medicine and Cellular Longevity
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- (2018) Shakeel Ijaz et al. BIOMEDICINE & PHARMACOTHERAPY
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- (2018) Kirsteen J. Campbell et al. Open Biology
- Apoptosis and necroptosis in the liver: a matter of life and death
- (2018) Robert F. Schwabe et al. Nature Reviews Gastroenterology & Hepatology
- Mitochondria in cancer: in the aspects of tumorigenesis and targeted therapy
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- (2018) Jie Sun et al. CHEMICAL ENGINEERING SCIENCE
- CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review
- (2018) Bagher Farhood et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis
- (2018) Guy A Conlon et al. JOURNAL OF PATHOLOGY
- ROS and the DNA damage response in cancer
- (2018) Upadhyayula Sai Srinivas et al. Redox Biology
- Paclitaxel-betulinic acid hybrid nanosuspensions for enhanced anti-breast cancer activity
- (2018) Ruoning Wang et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Toward a benign strategy for the manufacturing of betulinic acid
- (2017) Anna K. Ressmann et al. GREEN CHEMISTRY
- Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action
- (2017) Thazin Aung et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Betulinic Acid Induces Apoptosis in Differentiated PC12 Cells Via ROS-Mediated Mitochondrial Pathway
- (2017) Xi Wang et al. NEUROCHEMICAL RESEARCH
- Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models
- (2017) An-Qi Zeng et al. Oncotarget
- The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells
- (2017) Jun Yang et al. Oncotarget
- Multiple molecular targets in breast cancer therapy by betulinic acid
- (2016) Runlan Luo et al. BIOMEDICINE & PHARMACOTHERAPY
- Improvement of betulinic acid biosynthesis in yeast employing multiple strategies
- (2016) Chen Zhou et al. BMC BIOTECHNOLOGY
- Carbazole Aminoalcohols Induce Antiproliferation and Apoptosis of Human Tumor Cells by Inhibiting Topoisomerase I
- (2016) Weisi Wang et al. ChemMedChem
- Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?
- (2016) Filomena S. G. Silva et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Bioactive Pentacyclic Triterpenoids from the Leaves of Cleistocalyx operculatus
- (2016) Chen Wang et al. JOURNAL OF NATURAL PRODUCTS
- Natural Products as Promising Antitumoral Agents in Breast Cancer: Mechanisms of Action and Molecular Targets.
- (2016) Daniela Bonofiglio et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Caveolin-1 in the regulation of cell metabolism: a cancer perspective
- (2016) Zeribe Chike Nwosu et al. Molecular Cancer
- CYP716A179 functions as a triterpene C-28 oxidase in tissue-cultured stolons of Glycyrrhiza uralensis
- (2016) Keita Tamura et al. PLANT CELL REPORTS
- TWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion
- (2016) Cheryl L. Armstrong et al. Oncotarget
- Synthesis of heterocycle-modified betulinic acid derivatives as antitumor agents
- (2015) Hai-Wei Cui et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Betulinyl Sulfamates as Anticancer Agents and Radiosensitizers in Human Breast Cancer Cells
- (2015) Matthias Bache et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway
- (2015) Jhi Biau Foo et al. JOURNAL OF ETHNOPHARMACOLOGY
- Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis
- (2015) Gordon T Brown et al. JOURNAL OF PATHOLOGY
- Betulinic Acid and its Derivatives as Potential Antitumor Agents
- (2015) Dong-Mei Zhang et al. MEDICINAL RESEARCH REVIEWS
- Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model
- (2015) F Yang et al. Cell Death & Disease
- Synergistic cytotoxicity of cisplatin and Taxol in overcoming Taxol resistance through the inhibition of LDHA in oral squamous cell carcinoma
- (2015) LIN FENG et al. Oncology Letters
- Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview
- (2014) Dorina Gheorgheosu et al. Anti-Cancer Agents in Medicinal Chemistry
- Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina
- (2014) Hye-In Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Plant natural products: from traditional compounds to new emerging drugs in cancer therapy
- (2014) L. Ouyang et al. CELL PROLIFERATION
- Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment
- (2014) Se Young Park et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Heterocycle-fused lupane triterpenoids inhibit Leishmania donovani amastigotes
- (2014) Raisa Haavikko et al. MedChemComm
- The Transcriptional Repressor ZBTB4 Regulates EZH2 Through a MicroRNA-ZBTB4-Specificity Protein Signaling Axis
- (2014) Won Seok Yang et al. NEOPLASIA
- Recent insights into NF-κB signalling pathways and the link between inflammation and prostate cancer
- (2013) Daniel P. Nguyen et al. BJU INTERNATIONAL
- Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biologyin vivoandin vitro
- (2013) Tessa Moses et al. NEW PHYTOLOGIST
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway
- (2012) Yan-Fang Sun et al. FOOD CHEMISTRY
- A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana
- (2012) Yu Feng et al. FOOD CHEMISTRY
- NF-κB and the link between inflammation and cancer
- (2012) Joseph A. DiDonato et al. IMMUNOLOGICAL REVIEWS
- Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer
- (2012) X. Liu et al. MOLECULAR CANCER THERAPEUTICS
- Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: Role of Sp transcription factors and microRNA-27a:ZBTB10
- (2012) Susanne U. Mertens-Talcott et al. MOLECULAR CARCINOGENESIS
- New betulinic acid derivatives as potent proteasome inhibitors
- (2011) Keduo Qian et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors
- (2011) Sudhakar Chintharlapalli et al. BMC CANCER
- Effect of ionic liquid-containing system on betulinic acid production from betulin biotransformation by cultured Armillaria luteo-virens Sacc cells
- (2011) Fu Ming-liang et al. EUROPEAN FOOD RESEARCH AND TECHNOLOGY
- Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins
- (2011) Sudhakar Chintharlapalli et al. MOLECULAR CARCINOGENESIS
- Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
- (2011) K Kim et al. ONCOGENE
- Betulinic Acid has an Inhibitory Effect on Pancreatic Lipase and Induces Adipocyte Lipolysis
- (2011) Junghyun Kim et al. PHYTOTHERAPY RESEARCH
- CYP716A Subfamily Members are Multifunctional Oxidases in Triterpenoid Biosynthesis
- (2011) Ery O. Fukushima et al. PLANT AND CELL PHYSIOLOGY
- Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene Hyper-Producers
- (2011) Karina M. Madsen et al. PLoS One
- Non-canonical NF-κB signaling pathway
- (2010) Shao-Cong Sun CELL RESEARCH
- Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II
- (2010) Xia Xue et al. INVESTIGATIONAL NEW DRUGS
- Biotransformation optimization of betulin into betulinic acid production catalysed by cultured Armillaria luteo-virens Sacc ZJUQH100-6 cells
- (2010) J. Liu et al. JOURNAL OF APPLIED MICROBIOLOGY
- Anticancer Agents Derived from Natural Products
- (2010) E-Hu Liu et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Drugs that Target Specificity Proteins Downregulate Epidermal Growth Factor Receptor in Bladder Cancer Cells
- (2010) Gayathri Chadalapaka et al. MOLECULAR CANCER RESEARCH
- Metal Ion Interactions in the DNA Cleavage/Ligation Active Site of Human Topoisomerase IIα
- (2009) Joseph E. Deweese et al. BIOCHEMISTRY
- Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met
- (2009) S. Papineni et al. CARCINOGENESIS
- Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate in colon cancer cells
- (2009) Sudhakar Chintharlapalli et al. INTERNATIONAL JOURNAL OF CANCER
- Betulinic Acid Derivatives as Human Immunodeficiency Virus Type 2 (HIV-2) Inhibitors∥
- (2009) Zhao Dang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rational Design and Semisynthesis of Betulinic Acid Analogues as Potent Topoisomerase Inhibitors
- (2009) Fatma M. Abdel Bar et al. JOURNAL OF NATURAL PRODUCTS
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Peltophorum Africanum, a Traditional South African Medicinal Plant, Contains an Anti HIV-1 Constituent, Betulinic Acid
- (2009) Andros Theo et al. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
- (2008) S M Wigfield et al. BRITISH JOURNAL OF CANCER
- Shared Principles in NF-κB Signaling
- (2008) Matthew S. Hayden et al. CELL
- Topoisomerase I Requirement for Death Receptor-induced Apoptotic Nuclear Fission
- (2008) Olivier Sordet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Optimization of ultrasonic-assisted extraction (UAE) of betulin from white birch bark using response surface methodology
- (2008) Qi-he Chen et al. ULTRASONICS SONOCHEMISTRY
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