Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 44, Issue 5, Pages 415-432Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2018.12.001
Keywords
-
Categories
Funding
- National Academy of Sciences, India (NASI)
- NASI-Senior Scientist Platinum Jubilee Fellowship
Ask authors/readers for more resources
All organisms, including unicellular pathogens, compulsorily possess DNA topoisomerases for successful nucleic acid metabolism. But particular sub-types of topoisomerases exist, in all prokaryotes and in some unicellular eukaryotes, that are absent in higher eukaryotes. Moreover, topoisomerases from pathogenic members of a niche possess some unique molecular architecture and functionalities completely distinct from their nonpathogenic colleagues. This review will highlight the unique attributes associated with the structures and functions of topoisomerases from the unicellular pathogens, with special reference to bacteria and protozoan parasites. It will also summarise the progress made in the domain pertaining to the druggability of these topoisomerases, upon which a future platform for therapeutic development can be successfully constructed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available