Review
Oncology
Daniel Westaby, Juan M. Jimenez-Vacas, Ana Padilha, Andreas Varkaris, Steven P. Balk, Johann S. de Bono, Adam Sharp
Summary: This article discusses the treatment of prostate cancer and the need for new options. Triggering apoptosis in cancer cells is an attractive strategy, and BH3 mimetics have been designed for this purpose. The article provides an overview of cell death and apoptosis, focusing on the intrinsic pathway, and discusses the potential use of BH3 mimetics in treating prostate cancer.
Review
Immunology
Ryan R. Kowash, Esra A. Akbay
Summary: The adenosine pathway, particularly CD73, is a promising target for cancer immunotherapy, especially in non-small cell lung cancer (NSCLC) where CD73 expression is high. Combining immune checkpoint blockade (ICB) therapies with adenosine pathway inhibitors shows potential for the treatment of lung cancer. Clinical trials exploring the activation of both T and NK cells are in early stages. Understanding the role of CD73 in immune modulation and its intrinsic properties in tumor cells is important for future therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xihui Chen, Shiwen Wang, Li Zhang, Shuying Yuan, Tong Xu, Feng Zhu, Yanmei Zhang, Lijun Jia
Summary: This study demonstrated for the first time that celastrol inhibits tumor growth of ESCC by inducing apoptosis through both extrinsic and intrinsic pathways. The mechanism involves the transcriptional activation of ATF4 and the involvement of the FoxO3a-Bim pathway. This highlights celastrol as a promising therapeutic strategy for ESCC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chang-Hoon Hwang, Na-Kyoung Lee, Hyun-Dong Paik
Summary: Recent research has focused on the anti-cancer properties of Lactobacillus strains isolated from fermented foods. The study found that their anti-cancer effects are achieved by inducing apoptosis in cancer cells. However, consuming living organisms can lead to sepsis, especially in cancer patients with reduced immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zhenqingyun Shuai, Yongxiang Zheng, Jia Jiang, Rong Yu, Chun Zhang
Summary: In this study, a pro-apoptosis self-assembling protein nanoparticle was designed by fusing BH3 domain at the N-terminal of ferritin. The nanoparticle displayed stronger cytotoxicity against tumor cells and enhanced tumor cells apoptosis. These results suggest that BH3 domain can be designed as targeting pro-apoptotic nanoparticles, showing potential for targeted cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ramin Masoudi, Ali Mohammadi, Solmaz Morovati, Amir Ali Heidari, Mehdi Asad-Sangabi
Summary: This study investigated the apoptotic effects of the matrix (M) protein of Peste des petits ruminants virus (PPRV) on SW480 colorectal cancer cells. The results showed that the M protein induced apoptosis in 91% of CRC cells and up-regulated the expression of several apoptosis-related genes, as well as increased the Bax/Bcl-2 ratio.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Yunjing Zhang, Shiwen Wang, Yukun Chen, Junqian Zhang, Jing Yang, Jingrong Xian, Lihui Li, Hu Zhao, Robert M. Hoffman, Yanmei Zhang, Lijun Jia
Summary: The study illustrated the significant growth inhibition of esophageal squamous cell carcinoma (ESCC) by fangchinoline (FCL) through inducing cell cycle arrest and activating apoptosis pathways. FCL demonstrated its potential as an anti-ESCC agent by elucidating its tumor-suppressive efficacy and mechanisms.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Walter Douglas Fairlie, Erinna F. Lee
Summary: BCL-2, c-MYC and related proteins play crucial roles in normal cell functioning and are central to various cancers. Genetic lesions leading to deregulation of these proteins contribute to tumor development and survival depending on the cooperation between these protein families.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Eric Seidel, Silvia von Karstedt
Summary: Cancer cells show adaptive behavior during early transformation, and specific mutations optimize cellular fitness. However, the influence of the immune system on cellular adaptation during early carcinogenesis and the role of cell death pathways are still unclear.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Hussain Mubarak Al-Aamri, Helen R. Irving, Christopher Bradley, Terri Meehan-Andrews
Summary: Daunorubicin induces apoptosis in leukemic cells through both extrinsic and intrinsic pathways, with variations in sensitivities and timing of apoptotic responses observed among different cell lines. The lack of functional p53 may contribute to these differences and necessitates further exploration of alternative signaling mechanisms involved in apoptosis induction.
Article
Pharmacology & Pharmacy
Mohammad Piryaei, Bahareh Mehrparvar, Ali Mohammadian, Fatemeh Shahriari, Mohammad Amin Javidi
Summary: Thyroid cancer is a common type of endocrine-related cancer with increasing incidence in developed countries. Herbal medicine may provide practical benefits for cancer treatment. Hypericin was found to induce apoptotic cell death in thyroid cancer cells and modulate gene expression related to metastasis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia Nosalova, Alexandra Keselakova, Martin Kello, Miroslava Martinkova, Dominika Fabianova, Martina Bago Pilatova
Summary: Despite the decreasing trend in mortality from colorectal cancer, this study focused on the antiproliferative and pro-apoptotic effects of a compound on colon cancer cells. The compound was found to have concentration-dependent cytotoxic and antiproliferative effects, inducing both intrinsic and extrinsic apoptotic pathways and inhibiting cell migration. These findings suggest the potential of this compound as a future treatment for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Pooja Mittal, Sujata Singh, Rajesh Sinha, Anju Shrivastava, Archana Singh, Indrakant Kumar Singh
Summary: MCL-1 plays a crucial role in cancer cells and its overexpression is associated with drug resistance. Advancements in selective MCL-1 inhibitors offer new therapeutic strategies for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Oncology
Alexey Ponomarev, Zarema Gilazieva, Valeriya Solovyeva, Cinzia Allegrucci, Albert Rizvanov
Summary: The study of cancer stem cells is important because they play a crucial role in cancer complexity and treatment resistance. The tumor microenvironment modulates the function and survival of cancer stem cells. This review summarizes the regulation of cancer stemness through pluripotency factors and signaling pathways, and introduces current models used for studying cancer stem cells.
Article
Cell Biology
Albert Manzano-Munoz, Clara Alcon, Pablo Menendez, Manuel Ramirez, Felix Seyfried, Klaus-Michael Debatin, Luder H. Meyer, Josep Samitier, Joan Montero
Summary: Multiple targeted therapies are being explored for improving clinical outcome in pediatric and young adult BCP-ALL, especially for relapsed patients. Using DBP evaluation, MEK inhibitor trametinib and multi-target tyrosine kinase inhibitor sunitinib were found to enhance apoptotic priming in NRAS-mutant and KMT2A-rearranged cell lines with high FLT3 expression, respectively.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Waqar Haque, Vivek Verma, Mary R. Schwartz, Bora Lim, Niva Mangalampalli, Edward Brian Butler, Bin S. Teh
Summary: This study confirms that the response rates of metaplastic breast cancer (MBC) to neoadjuvant chemotherapy (NAC) are low, with pathologic complete response (pCR) being relatively infrequent. However, early-stage MBC may have a higher likelihood of achieving pCR.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Maryam Nemati Shafaee, Shalini Makawita, Bora Lim, Matthew J. Ellis, Michelle S. Ludwig
Summary: This study summarizes the methods of managing TNBC, particularly the unconventional approach of concurrent chemotherapy and radiation in cases of chemotherapy resistance.
CLINICAL BREAST CANCER
(2022)
Review
Oncology
Jason A. Mouabbi, Amy Hassan, Bora Lim, Gabriel N. Hortobagyi, Debasish Tripathy, Rachel M. Layman
Summary: Invasive lobular carcinoma (ILC) is the second most common subtype of breast cancer, with conflicting outcomes compared to invasive ductal carcinoma (IDC). Recent studies have shown that ILC and IDC are distinct entities.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Clinton Yam, Nour Abuhadra, Ryan Sun, Beatriz E. Adrada, Qing-Qing Ding, Jason B. White, Elizabeth E. Ravenberg, Alyson R. Clayborn, Vicente Valero, Debu Tripathy, Senthilkumar Damodaran, Banu K. Arun, Jennifer K. Litton, Naoto T. Ueno, Rashmi K. Murthy, Bora Lim, Luis Baez, Xiaoxian Li, Aman U. Buzdar, Gabriel N. Hortobagyi, Alistair M. Thompson, Elizabeth A. Mittendori, Gaiane M. Rauch, Rosalind P. Candelaria, Lei Huo, Stacy L. Moulder, Jeffrey T. Chang
Summary: This study analyzed the clinical outcomes, survival status, and genomic profiles of patients with metaplastic breast cancer (MpBC) who received neoadjuvant therapy. The results showed that MpBC patients had a lower response rate to the therapy, shorter survival time, and distinct genetic characteristics compared to non-metaplastic triple-negative breast cancer (TNBC) patients. Furthermore, some non-MpTNBC patients exhibited similar gene expression profiles and treatment responses to MpBC.
CLINICAL CANCER RESEARCH
(2022)
Editorial Material
Medicine, General & Internal
Pavlos Msaouel, Paula Jimenez-Fonseca, Bora Lim, Alberto Carmona-Bayonas, Giancarlo Agnelli
Summary: From the perspective of practicing clinicians, we recount the legacy of Sir David Roxbee Cox (15 July 1924 - 18 January 2022) and acknowledge his pioneering work in developing the logistic and Cox proportional hazard regression models, which revolutionized the analysis and interpretation of categorical and time-to-event survival outcomes in modern medicine. This legacy serves as an inspiration for those who follow in Sir David Cox's footsteps.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sang T. Kim, Yanshuo Chu, Mercy Misoi, Maria E. Suarez-Almazor, Jean H. Tayar, Huifang Lu, Maryam Buni, Jordan Kramer, Emma Rodriguez, Zulekha Hussain, Sattva S. Neelapu, Jennifer Wang, Amishi Y. Shah, Nizar M. Tannir, Matthew T. Campbell, Don L. Gibbons, Tina Cascone, Charles Lu, George R. Blumenschein, Mehmet Altan, Bora Lim, Vincente Valero, Monica E. Loghin, Janet Tu, Shannon N. Westin, Aung Naing, Guillermo Garcia-Manero, Noha Abdel-Wahab, Hussein A. Tawbi, Patrick Hwu, Isabella C. Glitza Oliva, Michael A. Davies, Sapna P. Patel, Jun Zou, Andrew Futreal, Adi Diab, Linghua Wang, Roza Nurieva
Summary: Immune checkpoint inhibitors can cause arthritis as an immune-related adverse event (irAE). Managing arthritis-irAE is difficult because standard treatments for arthritis should not hinder antitumor immunity. This study analyzed blood and synovial fluid samples from 20 patients with arthritis-irAE and found a prominent Th1-CD8(+) T cell axis in both blood and inflamed joints. The clonally expanded CX3CR1(hi) CD8(+) T cells in blood and CXCR3(hi) CD8(+) T cells in synovial fluid had significant TCR repertoire overlap. This research provides insights into the mechanisms, predictive biomarkers, and therapeutic targets for arthritis-irAE.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Gonghong Yan, Augustin Luna, Heping Wang, Behnaz Bozorgui, Xubin Li, Maga Sanchez, Zeynep Dereli, Nermin Kahraman, Goknur Kara, Xiaohua Chen, Caishang Zheng, Daniel McGrail, Nidhi Sahni, Yiling Lu, Ozgun Babur, Murat Cokol, Bora Lim, Bulent Ozpolat, Chris Sander, Gordon B. Mills, Anil Korkut
Summary: This study suggests that targeting MCL1 and BET may have therapeutic potential for the treatment of basal-like breast cancers. BET inhibition induces an adaptive response leading to the evasion of apoptosis in breast cancer cells driven by MCL1 protein. The mechanism involves upregulation of lipid synthesis enzymes, which affects cell motility and membrane fluidity, as well as the activation of HER2/EGFR signaling. MCL1 copy-number alterations are associated with the effectiveness of BET and MCL1 co-targeting.
Article
Biochemistry & Molecular Biology
Mokryun L. Baek, Junegoo Lee, Katherine E. Pendleton, Mariah J. Berner, Emily B. Goff, Lin Tan, Sara A. Martinez, Iqbal Mahmud, Tao Wang, Matthew D. Meyer, Bora Lim, James P. Barrish, Weston Porter, Philip L. Lorenzi, Gloria V. Echeverria
Summary: It was found that mitochondrial oxidative phosphorylation (OXPHOS) was elevated in triple negative breast cancer (TNBC) cells surviving neoadjuvant chemotherapy (NACT). DNA-damaging agents increased mitochondrial fusion and OXPHOS, while taxanes decreased these effects. Inhibiting mitochondrial fusion and fission suppressed regrowth of residual tumor cells. These findings offer potential strategies to overcome mitochondrial adaptations in chemoresistant TNBC.
Article
Multidisciplinary Sciences
Daniel Wang, Caroline E. Porter, Bora Lim, Amanda Rosewell Shaw, Catherine S. Robertson, Mae L. Woods, Ya Xu, Greyson G. W. Biegert, Daisuke Morita, Tao Wang, Bambi J. Grilley, Helen Heslop, Malcolm K. Brenner, Masataka Suzuki
Summary: We have demonstrated the strong antitumor activity of a binary oncolytic/helper-dependent adenovirus (CAdVEC) that lyses tumor cells, expresses IL-12 and PD-L1 blocking antibody. Following successful preclinical studies, we treated four patients with an ultralow dose of CAdVEC, which resulted in significant tumor control and immune repolarization. The combination of CAdVEC with systemic immune checkpoint antibodies induced sustained antitumor responses.
Article
Oncology
Nour Abuhadra, Ryan Sun, Clinton Yam, Gaiane M. Rauch, Qingqing Ding, Bora Lim, Alastair M. Thompson, Elizabeth A. Mittendorf, Beatriz E. Adrada, Senthil Damodaran, Kiran Virani, Jason White, Elizabeth Ravenberg, Jia Sun, Jaihee Choi, Rosalind Candelaria, Banu Arun, Naoto T. Ueno, Lumarie Santiago, Sadia Saleem, Sausan Abouharb, Rashmi K. Murthy, Nuhad Ibrahim, Aysegul Sahin, Vicente Valero, William Fraser Symmans, Jennifer K. Litton, Debu Tripathy, Stacy Moulder, Lei Huo
Summary: In this study, clinicopathologic features, including sTILs, Ki-67, PD-L1, and androgen receptor, were evaluated in 408 early-stage TNBC patients. Integrating high Ki-67 (>35%) and high sTILs (≥20%) in a computed response score model predicted a pCR rate of 65%. This model has the potential to refine patient selection for neoadjuvant clinical trials evaluating de-escalation strategies.
Article
Oncology
Evan N. Cohen, Gitanjali Jayachandran, Hui Gao, Phillip Peabody, Heather B. McBride, Franklin D. Alvarez, Megumi Kai, Juhee Song, Yu Shen, Jie S. Willey, Bora Lim, Vicente Valero, Naoto T. Ueno, James M. Reuben
Summary: Circulating tumor cells (CTCs) are valuable indicators for managing metastatic breast cancer (MBC). Enrichment of CTCs based on size and deformability can capture a wider range of tumor cells, providing a complementary approach to tissue biopsy. A longitudinal study using a microcavity array showed that the shift from epithelial CTCs to those with a mesenchymal expression pattern is associated with worse clinical outcomes.
Article
Oncology
Hui Chen, Qingqing Ding, Laila Khazai, Li Zhao, Senthil Damodaran, Jennifer K. Litton, Gaiane M. Rauch, Clinton Yam, Jeffrey T. Chang, Sahil Seth, Bora Lim, Alastair M. Thompson, Elizabeth A. Mittendorf, Beatriz Adrada, Kiran Virani, Jason B. White, Elizabeth Ravenberg, Xingzhi Song, Rosalind Candelaria, Banu Arun, Naoto T. Ueno, Lumarie Santiago, Sadia Saleem, Sausan Abouharb, Rashmi K. Murthy, Nuhad Ibrahim, Mark J. Routbort, Aysegul Sahin, Vicente Valero, William Fraser Symmans, Debu Tripathy, Wei-Lien Wang, Stacy Moulder, Lei Huo
Summary: This study compared the differences in PTEN expression between pre- and post-treatment tumors in patients with triple-negative breast cancer (TNBC). It also explored the possibility of using next-generation sequencing (NGS) as an alternative to immunohistochemistry (IHC) to identify PTEN loss. The results showed that testing different specimens by IHC may generate different PTEN results in a small proportion of TNBC patients.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Review
Oncology
Evthokia A. Hobbs, Natalie Chen, Alphi Kuriakose, Elizabeth Bonefas, Bora Lim
Summary: Breast cancer is a heterogeneous disease that presents challenges for biomarker-driven research and targeted therapies. Early detection, adaptation to chemotherapy resistance, and personalized treatment can improve outcomes. This review focuses on predictive biomarkers and detection methods for metastatic breast cancer.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Oncology
Hiroko Masuda, Kenichi Harano, Sakiko Miura, Ying Wang, Yuko Hirota, Oi Harada, Mohit Kumar Jolly, Yuki Matsunaga, Bora Lim, Anita L. Wood, Napa Parinyanitikul, Hee Jin Lee, Gyungyub Gong, Jason T. George, Herbert Levine, Jangsoon Lee, Xiaoping Wang, Anthony Lucci, Arvind Rao, Brock L. Schweitzer, O. Rayne Lawrence, Robert S. Seitz, Stephan W. Morris, David R. Hout, Seigo Nakamura, Savitri Krishnamurthy, Naoto T. Ueno
Summary: The study found that TNBC molecular subtype and IM signature frequently change after NST, and the results suggest that EMT is promoted in the changed subtypes.
JCO PRECISION ONCOLOGY
(2022)