A single‐domain intrabody targeting the follicle‐stimulating hormone receptor impacts FSH‐induced G protein‐dependent signalling

Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

(2023) Jia Duan et al.   Nature Communications

Autoregulation of GPCR signalling through the third intracellular loop

(2023) Fredrik Sadler et al.   NATURE

Intracellular VHHs to monitor and modulate GPCR signaling

(2022) Pauline Raynaud et al.   Frontiers in Endocrinology

Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor

(2021) Francesco De Pascali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Biology in the Clouds: The WeNMR-EOSC Ecosystem

(2021) Rodrigo V. Honorato et al.   Frontiers in Molecular Biosciences

Removal of a Conserved Disulfide Bond Does Not Compromise Mechanical Stability of a VHH Antibody Complex

(2019) Haipei Liu et al.   NANO LETTERS

QMEANDisCo – Distance Constraints Applied on Model Quality Estimation

(2019) Gabriel Studer et al.   BIOINFORMATICS

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors

(2018) Els Pardon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells

(2018) Qingwen Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

(2018) Conor McMahon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

(2018) Conor McMahon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

(2018) Matthieu Masureel et al.   Nature Chemical Biology

Structure-Function Relationships of the Follicle-Stimulating Hormone Receptor

(2018) Alfredo Ulloa-Aguirre et al.   Frontiers in Endocrinology

Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context

(2017) Dominic Devost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purinergic Receptor Transactivation by the β 2 -Adrenergic Receptor Increases Intracellular Ca 2+ in Nonexcitable Cells

(2017) Wayne Stallaert et al.   MOLECULAR PHARMACOLOGY

Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms

(2017) Silvia Sposini et al.   Cell Reports

Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology

(2017) Martino Bertoni et al.   Scientific Reports

GPCR Dynamics: Structures in Motion

(2016) Naomi R. Latorraca et al.   CHEMICAL REVIEWS

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

(2016) Dean P. Staus et al.   NATURE

The SWISS-MODEL Repository—new features and functionality

(2016) Stefan Bienert et al.   NUCLEIC ACIDS RESEARCH

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Assessing Gonadotropin Receptor Function by Resonance Energy Transfer-Based Assays

(2015) Mohammed Akli Ayoub et al.   Frontiers in Endocrinology

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

(2014) Aashish Manglik et al.   CURRENT OPINION IN CELL BIOLOGY

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling

(2012) Domitille Heitzler et al.   Molecular Systems Biology

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Preferential β-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation☆

(2010) Thibaud Tranchant et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY