Autoregulation of GPCR signalling through the third intracellular loop

Common coupling map advances GPCR-G protein selectivity

(2022) Alexander S Hauser et al.   eLife

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

(2022) Charlotte Avet et al.   eLife

β2-adrenoceptor ligand efficacy is tuned by a two-stage interaction with the Gαs C terminus

(2021) Keehun Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

(2021) Adrian L Sanborn et al.   eLife

Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

(2021) Qiufeng Liu et al.   Nature Chemical Biology

GPCR activation mechanisms across classes and macro/microscales

(2021) Alexander S. Hauser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The G protein database, GproteinDb

(2021) Gáspár Pándy-Szekeres et al.   NUCLEIC ACIDS RESEARCH

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

(2021) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Activation Microswitches in Adenosine Receptor A2A Function as Rheostats in the Cell Membrane

(2020) Ning Ma et al.   BIOCHEMISTRY

GPCRdb in 2021: integrating GPCR sequence, structure and function

(2020) Albert J Kooistra et al.   NUCLEIC ACIDS RESEARCH

Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A2A Receptor

(2019) Sangbae Lee et al.   STRUCTURE

Structural Insights into the Process of GPCR-G Protein Complex Formation

(2019) Xiangyu Liu et al.   CELL

Conformational plasticity of the intracellular cavity of GPCR−G-protein complexes leads to G-protein promiscuity and selectivity

(2019) Manbir Sandhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Bitopic Inhibition of ATP and Substrate Binding in Ser/Thr Kinases through a Conserved Allosteric Mechanism

(2018) Ning Ma et al.   BIOCHEMISTRY

A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation

(2017) Terry Kenakin   MOLECULAR PHARMACOLOGY

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

Priming GPCR signaling through the synergistic effect of two G proteins

(2017) Tejas M. Gupte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells

(2017) Lisa Seidel et al.   eLife

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

(2016) Dean P. Staus et al.   NATURE

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

β 2 -Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop

(2016) Matthew T. Eddy et al.   STRUCTURE

Investigation of allosteric coupling in human β2-adrenergic receptor in the presence of intracellular loop 3

(2016) Canan Ozgur et al.   BMC STRUCTURAL BIOLOGY

Structural Dynamics and Thermostabilization of Neurotensin Receptor 1

(2015) Sangbae Lee et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Structured and disordered facets of the GPCR fold

(2014) AJ Venkatakrishnan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Development and Characterization of Pepducins as Gs-biased Allosteric Agonists

(2014) Richard Carr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of G Protein-selective G Protein-coupled Receptor (GPCR) Conformations in Live Cells

(2013) Rabia U. Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

(2013) Aaron M. Ring et al.   NATURE

Effect of intracellular loop 3 on intrinsic dynamics of human β2-adrenergic receptor

(2013) Ozer Ozcan et al.   BMC STRUCTURAL BIOLOGY

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

MSMBuilder2: Modeling Conformational Dynamics on the Picosecond to Millisecond Scale

(2011) Kyle A. Beauchamp et al.   Journal of Chemical Theory and Computation

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Two distinct conformations of helix 6 observed in antagonist-bound structures of a  1-adrenergic receptor

(2011) R. Moukhametzianov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

(2010) Yongfang Zhao et al.   NATURE

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

Fine-tuning of GPCR activity by receptor-interacting proteins

(2009) Stefanie L. Ritter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Detergent binding explains anomalous SDS-PAGE migration of membrane proteins

(2009) Arianna Rath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring protein interactions and dynamics with solvatochromic fluorophores

(2009) Galen S. Loving et al.   TRENDS IN BIOTECHNOLOGY