Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry

(2017) Philipp Fronik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Single-molecule analysis of ligand efficacy in β2AR–G-protein activation

(2017) G. Glenn Gregorio et al.   NATURE

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state

(2016) Christopher T. Schafer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET

(2016) Yoon Namkung et al.   Nature Communications

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Propagation of conformational changes during μ-opioid receptor activation

(2015) Rémy Sounier et al.   NATURE

Allosteric regulation of G protein–coupled receptor activity by phospholipids

(2015) Rosie Dawaliby et al.   Nature Chemical Biology

Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma

(2014) Julia K L Walker et al.   CURRENT OPINION IN PHARMACOLOGY

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

(2013) Aaron M. Ring et al.   NATURE

N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor

(2012) Yaozhong Zou et al.   PLoS One

β2-adrenoceptor agonists: current and future direction

(2011) Mario Cazzola et al.   BRITISH JOURNAL OF PHARMACOLOGY

The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

(2011) Tony Warne et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Pathway and mechanism of drug binding to G-protein-coupled receptors

(2011) Ron O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptors

(2010) Jillian G Baker   BRITISH JOURNAL OF PHARMACOLOGY

Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex

(2010) Ucheor B Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

(2009) X. J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of two distinct inactive conformations of the  2-adrenergic receptor reconciles structural and biochemical observations

(2009) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-analysis of the risk of mortality with salmeterol and the effect of concomitant inhaled corticosteroid therapy

(2009) M Weatherall et al.   THORAX

Crystallizing Membrane Proteins for Structure Determination: Use of Lipidic Mesophases

(2008) Martin Caffrey   Annual Review of Biophysics

The risk of asthma mortality with inhaled long acting  -agonists

(2008) M Wijesinghe et al.   POSTGRADUATE MEDICAL JOURNAL