Drugs targeting the particle for arrangement of quaternary structure (PAQosome) and protein complex assembly

TTT (Tel2-Tti1-Tti2) Complex, the Co-Chaperone of PIKKs and a Potential Target for Cancer Chemotherapy

(2023) Sankhadip Bhadra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Mechanisms Driving and Regulating the AAA+ ATPase VCP/p97, an Important Therapeutic Target for Treating Cancer, Neurological and Infectious Diseases

(2023) Sepideh Valimehr et al.   Biomolecules

Unphosphorylated Form of the PAQosome Core Subunit RPAP3 Binds Ribosomal Preassembly Complexes to Modulate Ribosome Biogenesis

(2022) Maxime Pinard et al.   JOURNAL OF PROTEOME RESEARCH

The interaction between RPAP3 and TRBP reveals a possible involvement of the HSP90/R2TP chaperone complex in the regulation of miRNA activity

(2022) Yoann Abel et al.   NUCLEIC ACIDS RESEARCH

The Expression of the RUVBL1 Component of the R2TP Complex Correlates with Poor Prognosis in DLBCL

(2022) Moien Lone et al.   PATHOBIOLOGY

Discovery of small-molecule inhibitors of RUVBL1/2 ATPase

(2022) Gang Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dactylospongia elegans—A Promising Drug Source: Metabolites, Bioactivities, Biosynthesis, Synthesis, and Structural-Activity Relationship

(2022) Sabrin R. M. Ibrahim et al.   Marine Drugs

Quality control of protein complex assembly by the ubiquitin–proteasome system

(2022) Carlos Pla-Prats et al.   TRENDS IN CELL BIOLOGY

The Ubiquitin Proteasome System and Nutrient Stress Response

(2022) Erin Mackinnon et al.   Frontiers in Plant Science

Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases

(2022) Honami Yonezawa et al.   iScience

The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization

(2022) Jeffrey Lynham et al.   Biomolecules

Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition

(2022) Chengying Ma et al.   Nature Communications

Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H

(2022) Maxime Pinard et al.   Molecular Brain

AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors

(2021) Gang Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes

(2021) Thiago V. Seraphim et al.   STRUCTURE

RuvBL1 Maintains Resistance to TRAIL-Induced Apoptosis by Suppressing c-Jun/AP-1 Activity in Non-Small Cell Lung Cancer

(2021) Hao Li et al.   Frontiers in Oncology

Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors

(2021) Jaka Dernovšek et al.   Pharmaceutics

RNA Polymerase III Subunit Mutations in Genetic Diseases

(2021) Elisabeth Lata et al.   Frontiers in Molecular Biosciences

The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines

(2021) Yousuf A. Khan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

CryoEM of RUVBL1–RUVBL2–ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8

(2021) Marina Serna et al.   NUCLEIC ACIDS RESEARCH

Drug Development Targeting the Ubiquitin–Proteasome System (UPS) for the Treatment of Human Cancers

(2020) Xiaonan Zhang et al.   Cancers

RPAP3 C-Terminal Domain: A Conserved Domain for the Assembly of R2TP Co-Chaperone Complexes

(2020) Carlos F. Rodríguez et al.   Cells

Molecular Mechanisms of Heat Shock Factors in Cancer

(2020) Mikael Christer Puustinen et al.   Cells

AAA+ ATPases in Protein Degradation: Structures, Functions and Mechanisms

(2020) Shuwen Zhang et al.   Biomolecules

Sorafenib as an Inhibitor of RUVBL2

(2020) Nardin Nano et al.   Biomolecules

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

(2020) John F. Darby et al.   Scientific Reports

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM

(2020) Andres López-Perrote et al.   eLife

CB-6644 is a selective inhibitor of the RUVBL1/2 complex with anti-cancer activity

(2019) Victoria A Assimon et al.   ACS Chemical Biology

Target Identification of the Marine Natural Products Dictyoceratin-A and -C as Selective Growth Inhibitors in Cancer Cells Adapted to Hypoxic Environments

(2019) Takashi Kawachi et al.   Marine Drugs

Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM

(2019) Hugo Muñoz-Hernández et al.   Science Advances

SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress

(2019) Uda Ho et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion

(2019) Robert P. Sparks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral Infections

(2019) Donna M. Huryn et al.   JOURNAL OF MEDICINAL CHEMISTRY

CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

(2019) Junxin Chen et al.   Molecular Cancer

Benzothiazole derivatives as anticancer agents

(2019) Ali Irfan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

mTORC1 pathway in DNA damage response

(2018) Yinxing Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex

(2018) Julien Henri et al.   STRUCTURE

The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation

(2018) Walid A. Houry et al.   TRENDS IN BIOCHEMICAL SCIENCES

Synthesis and Structure–Activity Relationships of Inhibitors That Target the C-Terminal MEEVD on Heat Shock Protein 90

(2018) Marwa N. Rahimi et al.   ACS Medicinal Chemistry Letters

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

(2018) Fabrizio Martino et al.   Nature Communications

The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones

(2018) Chloé Maurizy et al.   Nature Communications

Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

(2018) Hiroshi Yamaguchi et al.   eLife

Structural basis for ATP-dependent chromatin remodelling by the INO80 complex

(2018) Sebastian Eustermann et al.   NATURE

Targeting Protein Kinase CK1δ with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View?

(2018) Maicol Bissaro et al.   ChemMedChem

Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics

(2018) Chiranjeev Sharma et al.   MOLECULES

Structure and dynamics of the yeast SWR1-nucleosome complex

(2018) Oliver Willhoft et al.   SCIENCE

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia

(2017) Huilin Huang et al.   Scientific Reports

A prefoldin-associated WD-repeat protein (WDR92) is required for the correct architectural assembly of motile cilia

(2016) Ramila S. Patel-King et al.   MOLECULAR BIOLOGY OF THE CELL

Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy

(2016) Caroline A. Ewens et al.   STRUCTURE

Structure, Dynamics, Assembly, and Evolution of Protein Complexes

(2015) Joseph A. Marsh et al.   Annual Review of Biochemistry

RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils

(2015) N. Zaarur et al.   EMBO JOURNAL

Protein Folding and Mechanisms of Proteostasis

(2015) José Díaz-Villanueva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression

(2015) Holly C. Hunsberger et al.   JOURNAL OF NEUROCHEMISTRY

Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1α and Induces Apoptosis in Human Colorectal Cancer Cells

(2015) Duc-Hiep Bach et al.   Marine Drugs

Discovery of a novel ligand that modulates the protein–protein interactions of the AAA+ superfamily oncoprotein reptin

(2015) Alan R. Healy et al.   Chemical Science

1H, 15N and 13C resonance assignments of the two TPR domains from the human RPAP3 protein

(2014) Marie-Eve Chagot et al.   Biomolecular NMR Assignments

Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells

(2014) Masayoshi Arai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of Pontin ATPase inhibitors through a molecular docking approach

(2014) Judith Elkaim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Pleiotropic Role of HSF1 in Neoplastic Transformation

(2014) Natalia Vydra et al.   CURRENT CANCER DRUG TARGETS

Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex

(2014) Zuzana Hořejší et al.   Cell Reports

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

(2013) Yuya Kamano et al.   FEBS LETTERS

RPAP3 splicing variant isoform 1 interacts with PIH1D1 to compose R2TP complex for cell survival

(2012) Miki Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay

(2012) Judith Elkaim et al.   BIOCHEMICAL JOURNAL

The Therapeutic Target Hsp90 and Cancer Hallmarks

(2012) Yoshihiko Miyata et al.   CURRENT PHARMACEUTICAL DESIGN

Tumor suppressor functions of FBW7 in cancer development and progression

(2012) Zhiwei Wang et al.   FEBS LETTERS

Targeting the ubiquitin–proteasome pathway with inorganic compounds to fight cancer: a challenge for the future

(2012) Lisa Dalla Via et al.   Future Medicinal Chemistry

Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells

(2012) Tomohisa Horibe et al.   Molecular Cancer

Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis

(2012) H.-L. Huang et al.   MOLECULAR CANCER THERAPEUTICS

The R2TP complex: Discovery and functions

(2011) Yoshito Kakihara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural and functional insights into a dodecameric molecular machine – The RuvBL1/RuvBL2 complex

(2011) Sabine Gorynia et al.   JOURNAL OF STRUCTURAL BIOLOGY

CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability

(2010) Zuzana Hořejší et al.   MOLECULAR CELL

HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II

(2010) Séverine Boulon et al.   MOLECULAR CELL

AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay

(2010) N. Izumi et al.   Science Signaling

TRAIL receptor targeting therapies for non-small cell lung cancer: Current status and perspectives

(2009) J.H. Stegehuis et al.   DRUG RESISTANCE UPDATES

Kinome Sirna Screen Identifies SMG-1 as a Negative Regulator of Hypoxia-inducible Factor-1α in Hypoxia

(2009) Run-Qiang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes

(2009) Philippe Cloutier et al.   METHODS

Riluzole Increases the Amount of Latent HSF1 for an Amplified Heat Shock Response and Cytoprotection

(2008) Jingxian Yang et al.   PLoS One