The mixing method used to formulate lipid nanoparticles affects mRNA delivery efficacy and organ tropism

Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery

(2022) Masatoshi Maeki et al.   JOURNAL OF CONTROLLED RELEASE

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

(2022) Min Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy

(2022) Jeong Pil Han et al.   Science Advances

The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs

(2022) Samuel T. LoPresti et al.   JOURNAL OF CONTROLLED RELEASE

Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer

(2022) Manon Ripoll et al.   Scientific Reports

Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects

(2022) Seyed Hossein Kiaie et al.   JOURNAL OF NANOBIOTECHNOLOGY

Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery

(2022) Xu Wang et al.   Nature Protocols

Lipid Nanoparticle Delivery of Chemically Modified NGF R100W mRNA Alleviates Peripheral Neuropathy

(2022) Xiang Yu et al.   Advanced Healthcare Materials

Phenylalanine hydroxylase mRNA rescues the phenylketonuria phenotype in mice

(2022) Maximiliano L. Cacicedo et al.   Frontiers in Bioengineering and Biotechnology

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

(2021) Min Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effectiveness of the TWO-DOSE BNT162b2 vaccine: analysis of real-world data

(2021) Gabriel Chodick et al.   CLINICAL INFECTIOUS DISEASES

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

(2021) Kiran Musunuru et al.   NATURE

mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease

(2021) Jingsong Cao et al.   Nature Communications

Non-liver mRNA Delivery

(2021) David Loughrey et al.   ACCOUNTS OF CHEMICAL RESEARCH

Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery

(2021) Jilian R. Melamed et al.   JOURNAL OF CONTROLLED RELEASE

Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice

(2021) Eriya Kenjo et al.   Nature Communications

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes

(2020) Cameron Webb et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

(2020) Tingting Jiang et al.   Nature Communications

A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo

(2020) Khalid A. Hajj et al.   NANO LETTERS

Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia

(2020) Lei Jiang et al.   Nature Communications

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

(2019) Khalid A. Hajj et al.   Small

Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets

(2019) Anthony Conway et al.   MOLECULAR THERAPY

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

(2019) Kimberly J. Hassett et al.   Molecular Therapy-Nucleic Acids

Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemia

(2019) Ding An et al.   EBioMedicine

Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening

(2019) Pedro P.G. Guimaraes et al.   JOURNAL OF CONTROLLED RELEASE

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

(2018) Masatoshi Maeki et al.   ADVANCED DRUG DELIVERY REVIEWS

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

(2018) Jasmine Viger-Gravel et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA

(2018) Rebecca L. Ball et al.   NANO LETTERS

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Cationic lipid-assisted nanoparticles for delivery of mRNA cancer vaccine

(2018) Ya-Nan Fan et al.   Biomaterials Science

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

(2018) Mohammad Ariful Islam et al.   Nature Biomedical Engineering

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

(2018) Cory D. Sago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma

(2018) Ian Lai et al.   Journal for ImmunoTherapy of Cancer

Microfluidic manufacturing of phospholipid nanoparticles: Stability, encapsulation efficacy, and drug release

(2017) Mariana Guimarães Sá Correia et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Controllable synthesis of functional nanoparticles by microfluidic platforms for biomedical applications – a review

(2017) Junping Ma et al.   LAB ON A CHIP

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

(2017) Ding An et al.   Cell Reports

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

(2016) Rebecca Ball et al.   International Journal of Nanomedicine

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery

(2016) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

(2015) Alex K. K. Leung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Mechanism of Macromolecular Structure Evolution in Self-Assembled Lipid Nanoparticles for siRNA Delivery

(2014) Marian E. Gindy et al.   LANGMUIR

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format

(2013) Kyle K.L. Phua et al.   JOURNAL OF CONTROLLED RELEASE

In Vitro–In Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery

(2012) Kathryn A. Whitehead et al.   ACS Nano

Solid lipid nanoparticles: Continuous and potential large-scale nanoprecipitation production in static mixers

(2012) Yuancai Dong et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

(2012) Nathan M Belliveau et al.   Molecular Therapy-Nucleic Acids

Effect of membrane charge density on the protein corona of cationic liposomes: Interplay between cationic charge and surface area

(2011) Giulio Caracciolo et al.   APPLIED PHYSICS LETTERS

Evolution of the Protein Corona of Lipid Gene Vectors as a Function of Plasma Concentration

(2011) Giulio Caracciolo et al.   LANGMUIR

mRNA as gene therapeutic: How to control protein expression

(2010) Geertrui Tavernier et al.   JOURNAL OF CONTROLLED RELEASE

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA