Lipin‐2 regulates the antiviral and anti‐inflammatory responses to interferon

Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents

(2022) Jinhe Han et al.   DRUG DISCOVERY TODAY

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

(2022) Qian Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Majeed Syndrome: A Review of the Clinical, Genetic and Immunologic Features

(2021) Polly J. Ferguson et al.   Biomolecules

Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β

(2021) Donald C. Vinh et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The role of type I interferon in the treatment of COVID‐19

(2021) Fatemeh Sodeifian et al.   JOURNAL OF MEDICAL VIROLOGY

Metabolism and Innate Immunity Meet at the Mitochondria

(2021) Amir Bahat et al.   Frontiers in Cell and Developmental Biology

Exploiting natural antiviral immunity for the control of pandemics: Lessons from Covid-19

(2021) Eleonora Aricò et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome

(2021) Kiran Iqbal Masood et al.   Scientific Reports

Lipin-2 degradation elicits a proinflammatory gene signature in macrophages

(2020) Asami Watahiki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex

(2020) Arti B. Dumbrepatil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting putative components of the mitochondrial permeability transition pore for novel therapeutics

(2020) Raymond J. Winquist et al.   BIOCHEMICAL PHARMACOLOGY

Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome

(2020) Wei-Yuan Hsieh et al.   Cell Metabolism

Serum Cytokine and Chemokine Profile in Relation to the Severity of Coronavirus Disease 2019 in China

(2020) Ying Chi et al.   JOURNAL OF INFECTIOUS DISEASES

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Microvascular dysfunction in COVID-19: the MYSTIC study

(2020) Alexandros Rovas et al.   ANGIOGENESIS

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

(2020) Lisa Miorin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

(2020) Yoriyuki Konno et al.   Cell Reports

Novel Majeed syndrome causing LPIN2 mutations link bone inflammation to inflammatory M2 macrophages and accelerated osteoclastogenesis

(2020) Farzana Bhuyan et al.   Arthritis & Rheumatology

The role of lipins in innate immunity and inflammation

(2019) María A. Balboa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inflammasomes in the pathophysiology of autoinflammatory syndromes

(2019) Sarang Tartey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modulation of the innate immune response by human cytomegalovirus

(2018) Matteo Biolatti et al.   INFECTION GENETICS AND EVOLUTION

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

The Dual Nature of Type I and Type II Interferons

(2018) Amanda J. Lee et al.   Frontiers in Immunology

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Lipin-2 regulates NLRP3 inflammasome by affecting P2X 7 receptor activation

(2016) Gema Lordén et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection

(2016) Chan-Wang J. Lio et al.   JOURNAL OF VIROLOGY

Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells

(2016) Hann Low et al.   Cell Reports

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway

(2016) Kevin A. Robertson et al.   PLOS BIOLOGY

Group V Secreted Phospholipase A2Is Upregulated by IL-4 in Human Macrophages and Mediates Phagocytosis via Hydrolysis of Ethanolamine Phospholipids

(2015) Julio M. Rubio et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

PRRs are watching you: Localization of innate sensing and signaling regulators

(2015) Jonathan Chow et al.   VIROLOGY

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Lipin 2 Binds Phosphatidic Acid by the Electrostatic Hydrogen Bond Switch Mechanism Independent of Phosphorylation

(2014) James M. Eaton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipin-1 Integrates Lipid Synthesis with Proinflammatory Responses during TLR Activation in Macrophages

(2014) Clara Meana et al.   JOURNAL OF IMMUNOLOGY

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators

(2014) S. Raza et al.   JOURNAL OF LEUKOCYTE BIOLOGY

STAT1  Is Not Dominant Negative and Is Capable of Contributing to Gamma Interferon-Dependent Innate Immunity

(2014) C. Semper et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

(2012) Mathieu Blanc et al.   IMMUNITY

Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages

(2012) Martín Valdearcos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular Localization and Role of Lipin-1 in Human Macrophages

(2011) M. Valdearcos et al.   JOURNAL OF IMMUNOLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

I B kinase   (IKK ) regulates the balance between type I and type II interferon responses

(2011) S.-L. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

(2011) J.-Y. Seo et al.   SCIENCE

Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

(2011) Mathieu Blanc et al.   PLOS BIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Coordinate Regulation of TLR-Mediated Arachidonic Acid Mobilization in Macrophages by Group IVA and Group V Phospholipase A2s

(2009) V. Ruiperez et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3

(2008) E. A. Nelson et al.   BLOOD

Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E

(2008) C. Sinzger et al.   JOURNAL OF GENERAL VIROLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay

(2008) L. Dolken et al.   RNA

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY